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- W2033376481 abstract "Transcranial direct current stimulation (tDCS) is a promising technique to treat a wide range of neurological conditions including stroke. The pathological processes following stroke may provide an exemplary system to investigate how tDCS promotes neuronal plasticity and functional recovery. Changes in synaptic function after stroke, such as reduced excitability, formation of aberrant connections, and deregulated plastic modifications, have been postulated to impede recovery from stroke. However, if tDCS could counteract these negative changes by influencing the system’s neurophysiology, it would contribute to the formation of functionally meaningful connections and the maintenance of existing pathways. This paper is aimed at providing a review of underlying mechanisms of tDCS and its application to stroke. In addition, to maximize the effectiveness of tDCS in stroke rehabilitation, future research needs to determine the optimal stimulation protocols and parameters. We discuss how stimulation parameters could be optimized based on electrophysiological activity. In particular, we propose that cortical synchrony may represent a biomarker of tDCS efficacy to indicate communication between affected areas. Understanding the mechanisms by which tDCS affects the neural substrate after stroke and finding ways to optimize tDCS for each patient are key to effective rehabilitation approaches." @default.
- W2033376481 created "2016-06-24" @default.
- W2033376481 creator A5001243211 @default.
- W2033376481 creator A5001308901 @default.
- W2033376481 creator A5034290522 @default.
- W2033376481 creator A5047020510 @default.
- W2033376481 creator A5089858629 @default.
- W2033376481 date "2013-01-01" @default.
- W2033376481 modified "2023-10-14" @default.
- W2033376481 title "Transcranial Direct Current Stimulation in Stroke Rehabilitation: A Review of Recent Advancements" @default.
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