FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033382471> ?p ?o ?g. }

• W2033382471 endingPage "e92" @default.
• W2033382471 startingPage "e92" @default.
• W2033382471 abstract "s / Digestive and Liver Disease 46 (2014) e85–e127 e93 Results: The rate of infections, mostly opportunistic, was comparable (21% IFX 27% ADA): 5 reactivations of HSV 1 and 2 (2 IFX, 3 ADA) and 2 of VZV (1 IFX, 1 ADA). The most severe infections occurred with IFX: one case of pneumonia caused by Mycoplasma and one reactivation of TB, despite prophylaxis with isoniazid. Acute infusion reactions were observed with IFX in 10 patients (18.18%). Sixty percent of them had to definitively suspend therapy because of the severity of reactions. There was only one case of urticarial rash due to ADA injection that led to therapy interruption. Drug-induced psoriasis occurred in 6 patients treated with IFX (10.90%) and in 4 with ADA (22.22%). Four suspended therapy (2 IFX, 2 ADA). Conclusions: Despite the great effectiveness in case of severe disease, IFX seems to have a slightly lower security profile compared to ADA in our experience. However, additional studies that involve larger populations of patients are needed to confirm these data. http://dx.doi.org/10.1016/j.dld.2014.07.073 URINARY METABOLOME OF CHILDREN WITH AUTISM AND PERVASIVE DEVELOPMENTAL DISORDER NOT OTHERWISE SPECIFIED Ruggiero Francavilla1,∗, Luigi Barberini2, Antonio Noto3, Raffaella Di Tonno1, Claudia F4, Marco Zaffanello5, Andrea De Giacomo6, Stefania Castellaneta7, Dmitry Grapov8, Maria De Angelis9, Vassilios Fanos3 1 Dipartimento Interdisciplinare di Medicina, University of Bari Aldo Moro, Bari, Italy 2 Department of Public Health Clinical and Molecular Medicine, University of Cagliari, Cagliari, Italy 3 Azienda Ospedaliera Universitaria-Neonatal Intensive Care Unit, Puericulture Institute and Neonatal Section, University of Cagliari, Cagliari, Italy 4 Department of Chemical and Geological Sciences, University of Cagliari, Cagliari, Italy 5 Section of Pediatrics, Department of Life and Reproduction Sciences, University of Verona, Verona, Italy 6 Child Neurological and Psychiatric Unit, Department of Neurological and Psychiatric Sciences, University of Bari Aldo Moro, Bari, Italy 7 Clinica Pediatrica, PO San Paolo, Bari, Italy 8 West Coast Metabolomics Center, University of California Davis, Sacramento, USA 9 Department of Soil, Plant and Food Sciences, University of Bari Aldo Moro, Bari, Italy Aim: This study aimed at investigating the urinarymetabolome of children with autistic spectrum disorders (ASD) in comparison to healthy children (HC). Methods: 30 ASD children (4–10 years of age; 14M) referred to Bari University Hospital and ten HC were studied. All children in the HC group were brother/sister of ADS children. None had been treated with antibiotics and/or probiotics and/or prebiotics for at least onemonth before sampling. Metabolomic analysis was performed by high throughput techniques (nuclear magnetic resonance spectroscopyandmass spectrometry) followingunivariate and multivariate statistical analysis. A supervised multivariate model has been applied to classify the metabolome alterations between ASD patients and controls and network-based model describing our ASD population was obtained. Results: ADS children showed alterations of several organic acids and sugars with an increase of: a) 3-(3-hydroxyphenyl)-3hydroxypropanoic that has been previously linked to autistic disorders; b) 3,4-dihydroxybutyric that is excreted in increased concentration also in patients with clinical findings including autistic behaviour; c) l-Phenylalanine, l-Tyrosine, p-hydroxyphenylacetic andHomovanillic acid all involved in the Tyrosine pathway leading to neurotransmitter cathecolamine. Conclusions: ADS children showed elevated concentration of several organic acids and sugars someofwhichhadbeenpreviously described as altered in autistic subjects. Diet and microbial intestinal flora may have a role in treatment and metabolomics analysis may have an important role in the follow-up. http://dx.doi.org/10.1016/j.dld.2014.07.074 CENTRAL VENOUS CATHETER INFECTIONS IN HOME PARENTERAL NUTRITION: CHANGES IN TWO LAST DECADES IN A PEDIATRIC COHORT OF SHORT BOWEL SYNDROME Teresa Capriati 1,∗, Vincenzo Di Ciommo Laurora2, Giuliano Torre1, Manila Candusso1, Anna Iacono1, Massimo Rollo1, Fabio Fusaro1, Chiara Grimaldi1, Jean De Ville De Goyet1, Antonella Diamanti1 1 Intestinal Failure Multidisciplinary Group, Bambino Gesu Children’s Hospital, IRCCS, Rome, Italy 2 Epidemiology and Biostatistics Unit, “Bambino Gesu” Children’s Hospital, IRCSS, Rome, Italy Objective: To study the changes in the rate of catheterassociated bloodstream infections (CABSIs) in the last two decades in a pediatric cohort of patients with short bowel syndrome (SBS) that received parenteral nutrition (PN) through a central venous catheter (CVC). Methods: We evaluated 100 children with SBS followed between 1994 and 2014 in one third level pediatric center and assessed the CABSI rate. The definition of CABSI was according to the Center for Disease Control (CDC) and the infections rate was expressed as the number of CABSI per 1000 CVC days as recommended by the Joint Commission on Accreditation of Healthcare Organizations (JCAHO) and by the CDC. The overall and the subdivided for decades (first decade from 1994 to 2003 and second decade from 2004 to 2014) CABSI rat on total days of PN were evaluated. Results: The overall prevalence of CABSI is 0.67 per 1000 CVC days. The CABSI rate in the first decadewas 1.33 per 1000 CVC days versus 0.78 per 1000 CVC days in the second decade. This change was statistically significant (p 0.0379, OR 1.665, CI 1.051–2.638). Conclusions: The advances in managing the CVC led to a reduced prevalence of CABSIs. The main aspects that have reduced the occurrence of CABSIs have been the localmeasures tominimize the risk for infection (use of taurolidine lock and of the antibiotic lock therapy in contaminated CVC) and the employ of the ultrasound-guided venepuncture for all CVC insertions. http://dx.doi.org/10.1016/j.dld.2014.07.075" @default.
• W2033382471 created "2016-06-24" @default.
• W2033382471 creator A5001370082 @default.
• W2033382471 creator A5006797062 @default.
• W2033382471 creator A5012979110 @default.
• W2033382471 creator A5023167006 @default.
• W2033382471 creator A5048146846 @default.
• W2033382471 creator A5062965111 @default.
• W2033382471 creator A5085956501 @default.
• W2033382471 date "2014-09-01" @default.
• W2033382471 modified "2023-10-14" @default.
• W2033382471 title "Assessing phenotype and disease course in children with earlier onset of IBD (<11 years). Data from two tertiary centres in the United Kingdom and Italy" @default.
• W2033382471 doi "https://doi.org/10.1016/j.dld.2014.07.071" @default.
• W2033382471 hasPublicationYear "2014" @default.
• W2033382471 type Work @default.
• W2033382471 sameAs 2033382471 @default.
• W2033382471 citedByCount "0" @default.
• W2033382471 crossrefType "journal-article" @default.
• W2033382471 hasAuthorship W2033382471A5001370082 @default.
• W2033382471 hasAuthorship W2033382471A5006797062 @default.
• W2033382471 hasAuthorship W2033382471A5012979110 @default.
• W2033382471 hasAuthorship W2033382471A5023167006 @default.
• W2033382471 hasAuthorship W2033382471A5048146846 @default.
• W2033382471 hasAuthorship W2033382471A5062965111 @default.
• W2033382471 hasAuthorship W2033382471A5085956501 @default.
• W2033382471 hasConcept C126322002 @default.
• W2033382471 hasConcept C187212893 @default.
• W2033382471 hasConcept C2777914695 @default.
• W2033382471 hasConcept C2778570526 @default.
• W2033382471 hasConcept C2779134260 @default.
• W2033382471 hasConcept C71924100 @default.
• W2033382471 hasConceptScore W2033382471C126322002 @default.
• W2033382471 hasConceptScore W2033382471C187212893 @default.
• W2033382471 hasConceptScore W2033382471C2777914695 @default.
• W2033382471 hasConceptScore W2033382471C2778570526 @default.
• W2033382471 hasConceptScore W2033382471C2779134260 @default.
• W2033382471 hasConceptScore W2033382471C71924100 @default.
• W2033382471 hasLocation W20333824711 @default.
• W2033382471 hasOpenAccess W2033382471 @default.
• W2033382471 hasPrimaryLocation W20333824711 @default.
• W2033382471 hasRelatedWork W141034082 @default.
• W2033382471 hasRelatedWork W1851114058 @default.
• W2033382471 hasRelatedWork W1973406436 @default.
• W2033382471 hasRelatedWork W1984408179 @default.
• W2033382471 hasRelatedWork W2140639042 @default.
• W2033382471 hasRelatedWork W2151296771 @default.
• W2033382471 hasRelatedWork W2162620521 @default.
• W2033382471 hasRelatedWork W2421419364 @default.
• W2033382471 hasRelatedWork W2985946612 @default.
• W2033382471 hasRelatedWork W3008561128 @default.
• W2033382471 hasRelatedWork W3011475930 @default.
• W2033382471 hasRelatedWork W3012335341 @default.
• W2033382471 hasRelatedWork W3029192564 @default.
• W2033382471 hasRelatedWork W3042552714 @default.
• W2033382471 hasRelatedWork W3109541482 @default.
• W2033382471 hasRelatedWork W3154873523 @default.
• W2033382471 hasRelatedWork W3195966220 @default.
• W2033382471 hasRelatedWork W2184584838 @default.
• W2033382471 hasVolume "46" @default.
• W2033382471 isParatext "false" @default.
• W2033382471 isRetracted "false" @default.
• W2033382471 magId "2033382471" @default.
• W2033382471 workType "article" @default.