Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033382475> ?p ?o ?g. }
- W2033382475 endingPage "2061" @default.
- W2033382475 startingPage "2054" @default.
- W2033382475 abstract "Antibody engineering facilitates the construction of different antibody formats [single chain variable fragment (scFv), diabody, full-size chimeric monoclonal antibody] with ease.We constructed recombinant antibodies against HCG, which is widely used in pregnancy testing and is also produced by a number of cancers.The recombinant antibodies were transiently expressed in tobacco leaves to levels of up to 40 mg of pure protein per kg fresh leaf weight. Enzyme linked immunosorbent assay (ELISA) and electrophoretic mobility assay (EMSA) confirmed antibody specificity for the beta subunit of beta-HCG. The efficacy was confirmed by inhibiting HCG induced testosterone production by Leydig cells in vitro and by blocking the HCG induced increase in mouse uterine weight in vivo.Passive immunization with recombinant HCG-specific antibodies may have clinical utility as (i) diagnostic and therapeutic tools for HCG-expressing cancers and (ii) contraceptive measures." @default.
- W2033382475 created "2016-06-24" @default.
- W2033382475 creator A5015033864 @default.
- W2033382475 creator A5017334361 @default.
- W2033382475 creator A5049288387 @default.
- W2033382475 creator A5049702449 @default.
- W2033382475 creator A5050549415 @default.
- W2033382475 creator A5067635515 @default.
- W2033382475 creator A5073546502 @default.
- W2033382475 creator A5076845264 @default.
- W2033382475 creator A5082638803 @default.
- W2033382475 date "2002-08-01" @default.
- W2033382475 modified "2023-09-27" @default.
- W2033382475 title "Efficacy of plant-produced recombinant antibodies against HCG" @default.
- W2033382475 cites W1212784958 @default.
- W2033382475 cites W1489175789 @default.
- W2033382475 cites W1555368198 @default.
- W2033382475 cites W1706832386 @default.
- W2033382475 cites W1744278443 @default.
- W2033382475 cites W1915689252 @default.
- W2033382475 cites W1983494459 @default.
- W2033382475 cites W1987534225 @default.
- W2033382475 cites W1992035964 @default.
- W2033382475 cites W1996820981 @default.
- W2033382475 cites W2003090737 @default.
- W2033382475 cites W2009087758 @default.
- W2033382475 cites W2009834607 @default.
- W2033382475 cites W2022564159 @default.
- W2033382475 cites W2025568953 @default.
- W2033382475 cites W2025738827 @default.
- W2033382475 cites W2038692005 @default.
- W2033382475 cites W2046741585 @default.
- W2033382475 cites W2047694403 @default.
- W2033382475 cites W2049005842 @default.
- W2033382475 cites W2050595849 @default.
- W2033382475 cites W2061234318 @default.
- W2033382475 cites W2063970744 @default.
- W2033382475 cites W2067067694 @default.
- W2033382475 cites W2067691456 @default.
- W2033382475 cites W2071440720 @default.
- W2033382475 cites W2084512447 @default.
- W2033382475 cites W2090519754 @default.
- W2033382475 cites W2112302621 @default.
- W2033382475 cites W2124072977 @default.
- W2033382475 cites W2129583079 @default.
- W2033382475 cites W2130930583 @default.
- W2033382475 cites W2133725030 @default.
- W2033382475 cites W2136602688 @default.
- W2033382475 cites W2151480508 @default.
- W2033382475 cites W2156037313 @default.
- W2033382475 cites W2156643886 @default.
- W2033382475 cites W2222638000 @default.
- W2033382475 cites W2298572164 @default.
- W2033382475 cites W2415935441 @default.
- W2033382475 cites W2461912812 @default.
- W2033382475 cites W2407863037 @default.
- W2033382475 doi "https://doi.org/10.1093/humrep/17.8.2054" @default.
- W2033382475 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12151436" @default.
- W2033382475 hasPublicationYear "2002" @default.
- W2033382475 type Work @default.
- W2033382475 sameAs 2033382475 @default.
- W2033382475 citedByCount "86" @default.
- W2033382475 countsByYear W20333824752012 @default.
- W2033382475 countsByYear W20333824752013 @default.
- W2033382475 countsByYear W20333824752014 @default.
- W2033382475 countsByYear W20333824752015 @default.
- W2033382475 countsByYear W20333824752016 @default.
- W2033382475 countsByYear W20333824752017 @default.
- W2033382475 countsByYear W20333824752019 @default.
- W2033382475 countsByYear W20333824752020 @default.
- W2033382475 countsByYear W20333824752021 @default.
- W2033382475 crossrefType "journal-article" @default.
- W2033382475 hasAuthorship W2033382475A5015033864 @default.
- W2033382475 hasAuthorship W2033382475A5017334361 @default.
- W2033382475 hasAuthorship W2033382475A5049288387 @default.
- W2033382475 hasAuthorship W2033382475A5049702449 @default.
- W2033382475 hasAuthorship W2033382475A5050549415 @default.
- W2033382475 hasAuthorship W2033382475A5067635515 @default.
- W2033382475 hasAuthorship W2033382475A5073546502 @default.
- W2033382475 hasAuthorship W2033382475A5076845264 @default.
- W2033382475 hasAuthorship W2033382475A5082638803 @default.
- W2033382475 hasBestOaLocation W20333824751 @default.
- W2033382475 hasConcept C104317684 @default.
- W2033382475 hasConcept C150903083 @default.
- W2033382475 hasConcept C153911025 @default.
- W2033382475 hasConcept C159654299 @default.
- W2033382475 hasConcept C185592680 @default.
- W2033382475 hasConcept C203014093 @default.
- W2033382475 hasConcept C207001950 @default.
- W2033382475 hasConcept C40767141 @default.
- W2033382475 hasConcept C542903549 @default.
- W2033382475 hasConcept C55493867 @default.
- W2033382475 hasConcept C86803240 @default.
- W2033382475 hasConceptScore W2033382475C104317684 @default.
- W2033382475 hasConceptScore W2033382475C150903083 @default.
- W2033382475 hasConceptScore W2033382475C153911025 @default.
- W2033382475 hasConceptScore W2033382475C159654299 @default.
- W2033382475 hasConceptScore W2033382475C185592680 @default.