FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033388533> ?p ?o ?g. }

• W2033388533 endingPage "2605" @default.
• W2033388533 startingPage "2600" @default.
• W2033388533 abstract "Retinoic acid (RA) slows growth and induces differentiation of tumor cells through activation of RA receptors (RARs). However, melanoma cell lines display highly variable responsiveness to RA, which is a poorly understood phenomenon. By using Northern and Western blot analyses, we show that RA-resistant A375 and RA-responsive S91 melanoma cells express comparable levels of major components of RAR-signaling pathways. However, A375 cells have substantially higher intracellular reactive oxygen species (ROS) levels than S91 cells. Lowering ROS levels in A375 cells through hypoxic culture conditions restores RAR-dependent trans-activity, which could be further enhanced by addition of the antioxidant N-acetyl-cysteine. Hypoxia also enhances RAR activity in the moderately RA-responsive C32 cells, which have intermediate ROS levels. Conversely, increasing oxidative stress in highly RA-responsive S91 and B16 cells, which have low ROS levels, by treatment with H(2)O(2) impairs RAR activity. Consistent with these observations, RA more potently inhibited the proliferation of hypoxic A375 cells than that of normoxic cells. Oxidative states diminish, whereas reducing conditions enhance, DNA binding of retinoid X receptor/RAR heterodimers in vitro, providing a molecular basis for the observed inverse correlation between RAR activity and ROS levels. The redox state of melanoma cells provides a novel, epigenetic control mechanism of RAR activity and RA resistance." @default.
• W2033388533 created "2016-06-24" @default.
• W2033388533 creator A5010885224 @default.
• W2033388533 creator A5013584551 @default.
• W2033388533 creator A5058816598 @default.
• W2033388533 creator A5082214467 @default.
• W2033388533 creator A5083735394 @default.
• W2033388533 date "2001-06-01" @default.
• W2033388533 modified "2023-10-06" @default.
• W2033388533 title "Redox Control of Retinoic Acid Receptor Activity: A Novel Mechanism for Retinoic Acid Resistance in Melanoma Cells*" @default.
• W2033388533 cites W14645725 @default.
• W2033388533 cites W1514826684 @default.
• W2033388533 cites W1516144786 @default.
• W2033388533 cites W1516915594 @default.
• W2033388533 cites W1569513589 @default.
• W2033388533 cites W1857381743 @default.
• W2033388533 cites W1909555660 @default.
• W2033388533 cites W1932027402 @default.
• W2033388533 cites W1973507868 @default.
• W2033388533 cites W1984447249 @default.
• W2033388533 cites W1994347228 @default.
• W2033388533 cites W2011821088 @default.
• W2033388533 cites W2021482004 @default.
• W2033388533 cites W2022891913 @default.
• W2033388533 cites W2023172513 @default.
• W2033388533 cites W2030932036 @default.
• W2033388533 cites W2045338351 @default.
• W2033388533 cites W2070693959 @default.
• W2033388533 cites W2078592237 @default.
• W2033388533 cites W2081684816 @default.
• W2033388533 cites W2105591452 @default.
• W2033388533 cites W2132826785 @default.
• W2033388533 cites W2133675982 @default.
• W2033388533 cites W2139466117 @default.
• W2033388533 cites W2148937254 @default.
• W2033388533 cites W2168731357 @default.
• W2033388533 cites W2313340812 @default.
• W2033388533 cites W2332419674 @default.
• W2033388533 cites W2397368613 @default.
• W2033388533 doi "https://doi.org/10.1210/endo.142.6.8201" @default.
• W2033388533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/11356710" @default.
• W2033388533 hasPublicationYear "2001" @default.
• W2033388533 type Work @default.
• W2033388533 sameAs 2033388533 @default.
• W2033388533 citedByCount "35" @default.
• W2033388533 countsByYear W20333885332012 @default.
• W2033388533 countsByYear W20333885332013 @default.
• W2033388533 countsByYear W20333885332014 @default.
• W2033388533 countsByYear W20333885332015 @default.
• W2033388533 countsByYear W20333885332016 @default.
• W2033388533 countsByYear W20333885332018 @default.
• W2033388533 countsByYear W20333885332019 @default.
• W2033388533 countsByYear W20333885332020 @default.
• W2033388533 countsByYear W20333885332021 @default.
• W2033388533 countsByYear W20333885332022 @default.
• W2033388533 countsByYear W20333885332023 @default.
• W2033388533 crossrefType "journal-article" @default.
• W2033388533 hasAuthorship W2033388533A5010885224 @default.
• W2033388533 hasAuthorship W2033388533A5013584551 @default.
• W2033388533 hasAuthorship W2033388533A5058816598 @default.
• W2033388533 hasAuthorship W2033388533A5082214467 @default.
• W2033388533 hasAuthorship W2033388533A5083735394 @default.
• W2033388533 hasBestOaLocation W20333885331 @default.
• W2033388533 hasConcept C104317684 @default.
• W2033388533 hasConcept C120197328 @default.
• W2033388533 hasConcept C128821507 @default.
• W2033388533 hasConcept C170493617 @default.
• W2033388533 hasConcept C185592680 @default.
• W2033388533 hasConcept C2775954498 @default.
• W2033388533 hasConcept C2776151105 @default.
• W2033388533 hasConcept C2777658100 @default.
• W2033388533 hasConcept C2781121885 @default.
• W2033388533 hasConcept C48349386 @default.
• W2033388533 hasConcept C502942594 @default.
• W2033388533 hasConcept C54355233 @default.
• W2033388533 hasConcept C55493867 @default.
• W2033388533 hasConcept C62112901 @default.
• W2033388533 hasConcept C63932345 @default.
• W2033388533 hasConcept C81885089 @default.
• W2033388533 hasConcept C86339819 @default.
• W2033388533 hasConcept C86803240 @default.
• W2033388533 hasConcept C95444343 @default.
• W2033388533 hasConceptScore W2033388533C104317684 @default.
• W2033388533 hasConceptScore W2033388533C120197328 @default.
• W2033388533 hasConceptScore W2033388533C128821507 @default.
• W2033388533 hasConceptScore W2033388533C170493617 @default.
• W2033388533 hasConceptScore W2033388533C185592680 @default.
• W2033388533 hasConceptScore W2033388533C2775954498 @default.
• W2033388533 hasConceptScore W2033388533C2776151105 @default.
• W2033388533 hasConceptScore W2033388533C2777658100 @default.
• W2033388533 hasConceptScore W2033388533C2781121885 @default.
• W2033388533 hasConceptScore W2033388533C48349386 @default.
• W2033388533 hasConceptScore W2033388533C502942594 @default.
• W2033388533 hasConceptScore W2033388533C54355233 @default.
• W2033388533 hasConceptScore W2033388533C55493867 @default.
• W2033388533 hasConceptScore W2033388533C62112901 @default.
• W2033388533 hasConceptScore W2033388533C63932345 @default.
• W2033388533 hasConceptScore W2033388533C81885089 @default.

• next