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- W2033396439 abstract "1. The application of high-voltage paper electrophoresis (h.v.p.e.) to the identification of drug metabolites in urine and bile has been investigated. 2. The major urinary metabolite of [3H]salbutamol in man had an electrophoretic mobility indicative of a sulphate ester. 3. A metabolite of [14C]ranitidine present in rat bile was shown to contain an ionized group with a pKa corresponding to a carboxylic acid. 4. The electrophoretic mobility-pH profile of a metabolite of radiolabelled N-cyano-N-[2-[5-(dimethylaminomethyl)-2-furanylmethylthio]ethyl]-N-methylguanidine (14C-AH 18801) excreted in dog urine suggested that oxidation of the tertiary amine group of the compound had occurred. 5. H.v.p.e. provided valuable information on the structure of both phases I and phase II metabolites at a stage when the material was insufficiently pure for identification by other techniques." @default.
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- W2033396439 date "1981-01-01" @default.
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- W2033396439 title "Applications of high-voltage paper electrophoresis for the characterization of drug metabolites" @default.
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- W2033396439 doi "https://doi.org/10.3109/00498258109045321" @default.
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