Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033408017> ?p ?o ?g. }
- W2033408017 endingPage "26" @default.
- W2033408017 startingPage "11" @default.
- W2033408017 abstract "Summary. The physiological protection against bleeding is secured by platelet adhesion to the site of injury and sealing of the defect. The first step involves the arrest of platelets that have adhered to subendothelial structures, primarily collagen, at the site of injury. Under conditions of low shear rates, platelet adhesion to the damaged vessel wall is mediated by several proteins, including von Willebrand factor (VWF). However, under conditions of high shear, aggregation occurs only in the presence of soluble VWF. In solution, VWF becomes immobilized via its A3 domain on the fibrillar collagen of the vessel wall and acts as an intermediary between collagen and the platelet receptor glycoprotein Ibα (GPIbα), which is the only platelet receptor that does not require prior activation for bond formation. After GPIbα binds to the A1 domain of its main ligand VWF, further activation of the platelet via intracellular signalling occurs, allowing other receptors to engage VWF and collagen and thereby reinforcing permanent adhesion. On this first layer of adherent platelets, soluble VWF binds and uncoils, thereby attracting more platelets. Platelet interaction with immobilized and soluble VWF may also generate platelet‐derived microparticles that exhibit pro‐coagulant activity. Full growth of a multilayered platelet aggregate comprises binding of the platelet receptor integrin αIIbβ3 to VWF and fibrinogen. In addition, the surface of the activated platelets accelerates the coagulation cascade, which, by its end product fibrin, stabilizes the growing platelet thrombus. This article summarizes the characteristics and role of VWF in the coagulation cascade." @default.
- W2033408017 created "2016-06-24" @default.
- W2033408017 creator A5066175035 @default.
- W2033408017 date "2008-08-29" @default.
- W2033408017 modified "2023-10-01" @default.
- W2033408017 title "Function of von Willebrand factor in haemostasis and thrombosis" @default.
- W2033408017 cites W1220769216 @default.
- W2033408017 cites W131829654 @default.
- W2033408017 cites W1495944780 @default.
- W2033408017 cites W1509156028 @default.
- W2033408017 cites W1557940991 @default.
- W2033408017 cites W1599606526 @default.
- W2033408017 cites W1604878593 @default.
- W2033408017 cites W164651796 @default.
- W2033408017 cites W1853024284 @default.
- W2033408017 cites W1926928802 @default.
- W2033408017 cites W1934180097 @default.
- W2033408017 cites W1963549684 @default.
- W2033408017 cites W1964151860 @default.
- W2033408017 cites W1970959909 @default.
- W2033408017 cites W1971260677 @default.
- W2033408017 cites W1972832497 @default.
- W2033408017 cites W1974175370 @default.
- W2033408017 cites W1974353826 @default.
- W2033408017 cites W1974454117 @default.
- W2033408017 cites W1976738617 @default.
- W2033408017 cites W1981284849 @default.
- W2033408017 cites W1981742349 @default.
- W2033408017 cites W1982172668 @default.
- W2033408017 cites W1984335380 @default.
- W2033408017 cites W1985013747 @default.
- W2033408017 cites W1992646081 @default.
- W2033408017 cites W1993486440 @default.
- W2033408017 cites W1994111747 @default.
- W2033408017 cites W1995757411 @default.
- W2033408017 cites W1997269140 @default.
- W2033408017 cites W1999631326 @default.
- W2033408017 cites W1999680744 @default.
- W2033408017 cites W2007330692 @default.
- W2033408017 cites W2009264307 @default.
- W2033408017 cites W2013199099 @default.
- W2033408017 cites W2016938853 @default.
- W2033408017 cites W2022094318 @default.
- W2033408017 cites W2026211638 @default.
- W2033408017 cites W2029998262 @default.
- W2033408017 cites W2030665169 @default.
- W2033408017 cites W2032134839 @default.
- W2033408017 cites W2036284239 @default.
- W2033408017 cites W2036904069 @default.
- W2033408017 cites W2038366724 @default.
- W2033408017 cites W2039881470 @default.
- W2033408017 cites W2041065426 @default.
- W2033408017 cites W2042038589 @default.
- W2033408017 cites W2043321286 @default.
- W2033408017 cites W2044505929 @default.
- W2033408017 cites W2045737112 @default.
- W2033408017 cites W2046417991 @default.
- W2033408017 cites W2046499889 @default.
- W2033408017 cites W2047676588 @default.
- W2033408017 cites W2049364649 @default.
- W2033408017 cites W2050281169 @default.
- W2033408017 cites W2054540030 @default.
- W2033408017 cites W2054657407 @default.
- W2033408017 cites W2055776235 @default.
- W2033408017 cites W2059836801 @default.
- W2033408017 cites W2062037750 @default.
- W2033408017 cites W2062522942 @default.
- W2033408017 cites W2068262290 @default.
- W2033408017 cites W2071119634 @default.
- W2033408017 cites W2072629623 @default.
- W2033408017 cites W2075013504 @default.
- W2033408017 cites W2080733678 @default.
- W2033408017 cites W2083373721 @default.
- W2033408017 cites W2093612398 @default.
- W2033408017 cites W2098586577 @default.
- W2033408017 cites W2104971142 @default.
- W2033408017 cites W2114604545 @default.
- W2033408017 cites W2118277673 @default.
- W2033408017 cites W2119250965 @default.
- W2033408017 cites W2120325617 @default.
- W2033408017 cites W2121117014 @default.
- W2033408017 cites W2121859722 @default.
- W2033408017 cites W2122433970 @default.
- W2033408017 cites W2126683943 @default.
- W2033408017 cites W2127451188 @default.
- W2033408017 cites W2129464080 @default.
- W2033408017 cites W2129958400 @default.
- W2033408017 cites W2137827663 @default.
- W2033408017 cites W2144398438 @default.
- W2033408017 cites W2150117652 @default.
- W2033408017 cites W2152936026 @default.
- W2033408017 cites W2158841112 @default.
- W2033408017 cites W2175263209 @default.
- W2033408017 cites W2230724256 @default.
- W2033408017 cites W2283946744 @default.
- W2033408017 cites W2295465622 @default.
- W2033408017 cites W232856255 @default.
- W2033408017 cites W2335477357 @default.