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- W2033408596 abstract "Interleukin-15 (IL-15) is a newly-discovered cytokine that is produced by activated monocytes early in the course of the innate immune response. IL-15 is able to bind to components of the interleukin-2 receptor (IL-2R) despite the fact that it has no sequence homology with IL-2. IL-15 stimulates human natural killer cell proliferation, cytotoxicity, and cytokine production and can substitute for IL-2 under most conditions. In vitro studies indicate that monocyte-derived IL-15 may be an important determinant of IFN-gamma production by NK cells. In addition, IL-15 is able to promote the survival of natural killer cells under serum-free conditions. The IL-15 receptor is a heterotrimeric complex which is composed of the IL-2R beta and gamma chains in combination with a unique alpha chain (IL-15 alpha). The IL-15R alpha chain has strong sequence homology to the IL-2R alpha chain and confers high affinity binding to the IL-15R. In contrast to IL-2, transcript for IL-15 and IL-15 alpha is expressed in a number of tissues and indicates that IL-15 may be an important ligand for cells that express components of the IL-2R." @default.
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- W2033408596 date "1998-01-01" @default.
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- W2033408596 title "Interleukin-15 as a potential regulator of the innate immune response" @default.
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- W2033408596 doi "https://doi.org/10.1590/s0100-879x1998000100001" @default.
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