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• W2033410425 abstract "In cultured human lung fibroblasts treated with Clostridium difficile toxin B, the development of the cytopathogenic effect was inhibited by the proton ionophore monensin but was not affected by some other ionophores. The calcium channel blockers verapamil and LaCl3 protected the cells against intoxication, as did the calmodulin antagonists trifluoperazine, amitriptyline, R 24571, and dansylcadaverine. Since these agents could not prevent intoxication when added after the toxin internalization was completed, we suggest that calmodulin and uptake of extracellular calcium are needed for the internalization but not for the cytosolic action of the toxin." @default.
• W2033410425 created "2016-06-24" @default.
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• W2033410425 date "1987-07-01" @default.
• W2033410425 modified "2023-09-23" @default.
• W2033410425 title "Calcium and calmodulin in cellular intoxication withClostridium difficile toxin B" @default.
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• W2033410425 doi "https://doi.org/10.1002/jcp.1041320124" @default.
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