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• W2033411054 endingPage "86" @default.
• W2033411054 startingPage "49" @default.
• W2033411054 abstract "Complex paracrine interactions exist between endothelial cells and cardiac myocytes in the heart. Cardiac endothelial cells release (or metabolize) several diffusible agents (e.g., nitric oxide [NO], endothelin-1, angiotensin II, adenylpurines) that exert direct effects on myocyte function, independent of changes in coronary flow. Some of these mediators are also generated by cardiac myocytes, often under pathological conditions. This review focuses on the role of NO in this paracrine/autocrine pathway. NO modulates several aspects of physiological myocardial function (e.g., excitation-contraction coupling; myocardial relaxation; diastolic function; the Frank-Starling response; heart rate; beta-adrenergic inotropic response; and myocardial energetics and substrate metabolism). The effects of NO are influenced by its cellular and enzymatic source, the amount generated, the presence of reactive oxygen species, interactions with neurohumoral and other stimuli, and the relative activation of cyclic GMP-dependent and -independent signal transduction pathways. The relative physiological importance of endothelium- and myocyte-derived NO remains to be established. In pathological situations (e.g., ischemia-reperfusion, left ventricular hypertrophy, heart failure, transplant vasculopathy and rejection, myocarditis), NO can potentially exert beneficial or deleterious effects. Beneficial effects of NO can result from endothelial-type nitric oxide synthase-derived NO or from spatially and temporally restricted expression of the inducible isoform, inducible-type nitric oxide synthase. Deleterious effects may result from (1) deficiency of NO or (2) excessive production, often inducible-type nitric oxide synthase-derived and usually with concurrent reactive oxygen species production and peroxynitrite formation. The balance between beneficial and deleterious effects of NO is of key importance with respect to its pathophysiological role." @default.
• W2033411054 created "2016-06-24" @default.
• W2033411054 creator A5000034477 @default.
• W2033411054 creator A5019437338 @default.
• W2033411054 date "2000-04-01" @default.
• W2033411054 modified "2023-10-17" @default.
• W2033411054 title "Paracrine and autocrine effects of nitric oxide on myocardial function" @default.
• W2033411054 cites W112845012 @default.
• W2033411054 cites W118855494 @default.
• W2033411054 cites W119779276 @default.
• W2033411054 cites W130015245 @default.
• W2033411054 cites W139140676 @default.
• W2033411054 cites W1490576088 @default.
• W2033411054 cites W150519449 @default.
• W2033411054 cites W1505685265 @default.
• W2033411054 cites W1531734841 @default.
• W2033411054 cites W1559221509 @default.
• W2033411054 cites W1560777399 @default.
• W2033411054 cites W1581028088 @default.
• W2033411054 cites W1618037986 @default.
• W2033411054 cites W1630602822 @default.
• W2033411054 cites W1715320380 @default.
• W2033411054 cites W1725300350 @default.
• W2033411054 cites W1747994692 @default.
• W2033411054 cites W1795275022 @default.
• W2033411054 cites W1816221338 @default.
• W2033411054 cites W1821918060 @default.
• W2033411054 cites W1832460954 @default.
• W2033411054 cites W1847031529 @default.
• W2033411054 cites W1855768444 @default.
• W2033411054 cites W1889558125 @default.
• W2033411054 cites W1947522959 @default.
• W2033411054 cites W1948883382 @default.
• W2033411054 cites W1964972368 @default.
• W2033411054 cites W1966939913 @default.
• W2033411054 cites W1967883278 @default.
• W2033411054 cites W1969573866 @default.
• W2033411054 cites W1970222518 @default.
• W2033411054 cites W1971338637 @default.
• W2033411054 cites W1973003784 @default.
• W2033411054 cites W1973304156 @default.
• W2033411054 cites W1973375324 @default.
• W2033411054 cites W1973470186 @default.
• W2033411054 cites W1973985929 @default.
• W2033411054 cites W1974235853 @default.
• W2033411054 cites W1974251201 @default.
• W2033411054 cites W1974431388 @default.
• W2033411054 cites W1974528590 @default.
• W2033411054 cites W1974765145 @default.
• W2033411054 cites W1974833220 @default.
• W2033411054 cites W1975117893 @default.
• W2033411054 cites W1976400973 @default.
• W2033411054 cites W1976553965 @default.
• W2033411054 cites W1977136741 @default.
• W2033411054 cites W1978842162 @default.
• W2033411054 cites W1979026148 @default.
• W2033411054 cites W1979292368 @default.
• W2033411054 cites W1980517287 @default.
• W2033411054 cites W1981203221 @default.
• W2033411054 cites W1981266878 @default.
• W2033411054 cites W1981643267 @default.
• W2033411054 cites W1981792539 @default.
• W2033411054 cites W1982947678 @default.
• W2033411054 cites W1983304603 @default.
• W2033411054 cites W1983505487 @default.
• W2033411054 cites W1985212527 @default.
• W2033411054 cites W1986243508 @default.
• W2033411054 cites W1986947248 @default.
• W2033411054 cites W1987662736 @default.
• W2033411054 cites W1988574165 @default.
• W2033411054 cites W1988920507 @default.
• W2033411054 cites W1989115514 @default.
• W2033411054 cites W1989920052 @default.
• W2033411054 cites W1990793066 @default.
• W2033411054 cites W1991484350 @default.
• W2033411054 cites W1992613123 @default.
• W2033411054 cites W1994857549 @default.
• W2033411054 cites W1995138632 @default.
• W2033411054 cites W1996462984 @default.
• W2033411054 cites W1996815755 @default.
• W2033411054 cites W1997157483 @default.
• W2033411054 cites W2000389735 @default.
• W2033411054 cites W2000439702 @default.
• W2033411054 cites W2001496558 @default.
• W2033411054 cites W2001873621 @default.
• W2033411054 cites W2002097466 @default.
• W2033411054 cites W2002879920 @default.
• W2033411054 cites W2003102975 @default.
• W2033411054 cites W2004076325 @default.
• W2033411054 cites W2004200451 @default.
• W2033411054 cites W2004382577 @default.
• W2033411054 cites W2004874253 @default.
• W2033411054 cites W2005591501 @default.
• W2033411054 cites W2006422381 @default.
• W2033411054 cites W2007068107 @default.
• W2033411054 cites W2007472328 @default.
• W2033411054 cites W2007865489 @default.
• W2033411054 cites W2007964357 @default.

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