Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033415150> ?p ?o ?g. }
- W2033415150 endingPage "2271" @default.
- W2033415150 startingPage "2260" @default.
- W2033415150 abstract "Abstract We have previously described the discovery of N ‐alkylated iminosugars that showed immunosuppressive activity both in vitro and in vivo. Herein, we report the synthesis and biological evaluation of N ‐arylated lactam‐type iminosugar derivatives. The synthesis started from simple monosaccharides and featured a Buchwald–Hartwig coupling reaction to construct the key N ‐aryl connection, thereby providing a highly diverse compound library. Structure–activity relationship studies, guided by a mouse‐spleen‐proliferation assay, led to the identification of ′hit′ compound 12 f . Subsequently, the systematic modification of compound 12 f afforded compounds 21 h , 21 k , 21 n , 21 t , and 21 x with improved activities (IC 50 =12–30 μ M ) and low Jurkat cytotoxicities (IC 50 >100 μ M ). These new compounds also inhibited the secretion of IFN‐γ and IL‐4, which are hallmark cytokines of Th1 and Th2 cells, respectively. This work demonstrated that the N ‐arylated iminosugar structure represents a new scaffold with immunosuppressive activity." @default.
- W2033415150 created "2016-06-24" @default.
- W2033415150 creator A5004588799 @default.
- W2033415150 creator A5005071062 @default.
- W2033415150 creator A5033959946 @default.
- W2033415150 creator A5041682827 @default.
- W2033415150 creator A5042144096 @default.
- W2033415150 creator A5047118448 @default.
- W2033415150 creator A5063582505 @default.
- W2033415150 creator A5083674171 @default.
- W2033415150 date "2014-04-02" @default.
- W2033415150 modified "2023-10-14" @default.
- W2033415150 title "<i>N</i>-Arylated-Lactam-Type Iminosugars as New Immunosuppressive Agents: Discovery, Optimization, and Biological Evaluation" @default.
- W2033415150 cites W1923342267 @default.
- W2033415150 cites W1965629935 @default.
- W2033415150 cites W1968577387 @default.
- W2033415150 cites W1970957276 @default.
- W2033415150 cites W1971433333 @default.
- W2033415150 cites W1978500153 @default.
- W2033415150 cites W1979123927 @default.
- W2033415150 cites W1979703254 @default.
- W2033415150 cites W1980337077 @default.
- W2033415150 cites W1982346259 @default.
- W2033415150 cites W1987227171 @default.
- W2033415150 cites W1990005521 @default.
- W2033415150 cites W1990980469 @default.
- W2033415150 cites W1993536559 @default.
- W2033415150 cites W1994403933 @default.
- W2033415150 cites W1995911981 @default.
- W2033415150 cites W1999990350 @default.
- W2033415150 cites W2002809810 @default.
- W2033415150 cites W2008996304 @default.
- W2033415150 cites W2009747356 @default.
- W2033415150 cites W2013142277 @default.
- W2033415150 cites W2018849208 @default.
- W2033415150 cites W2019440591 @default.
- W2033415150 cites W2023654436 @default.
- W2033415150 cites W2025626805 @default.
- W2033415150 cites W2027897295 @default.
- W2033415150 cites W2040260585 @default.
- W2033415150 cites W2041228182 @default.
- W2033415150 cites W2042679990 @default.
- W2033415150 cites W2056786571 @default.
- W2033415150 cites W2058285823 @default.
- W2033415150 cites W2079639372 @default.
- W2033415150 cites W2081391255 @default.
- W2033415150 cites W2085903934 @default.
- W2033415150 cites W2087102224 @default.
- W2033415150 cites W2087727066 @default.
- W2033415150 cites W2092939928 @default.
- W2033415150 cites W2094664836 @default.
- W2033415150 cites W2094801848 @default.
- W2033415150 cites W2105840619 @default.
- W2033415150 cites W2122174215 @default.
- W2033415150 cites W2172754735 @default.
- W2033415150 cites W2312702239 @default.
- W2033415150 cites W2316733195 @default.
- W2033415150 cites W2950250402 @default.
- W2033415150 cites W2950854001 @default.
- W2033415150 cites W2951306451 @default.
- W2033415150 cites W2951341620 @default.
- W2033415150 cites W2951443076 @default.
- W2033415150 cites W2951973061 @default.
- W2033415150 cites W2952439731 @default.
- W2033415150 cites W2952806719 @default.
- W2033415150 cites W4238627525 @default.
- W2033415150 cites W4313314629 @default.
- W2033415150 cites W2328993228 @default.
- W2033415150 doi "https://doi.org/10.1002/asia.201400023" @default.
- W2033415150 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24700650" @default.
- W2033415150 hasPublicationYear "2014" @default.
- W2033415150 type Work @default.
- W2033415150 sameAs 2033415150 @default.
- W2033415150 citedByCount "10" @default.
- W2033415150 countsByYear W20334151502015 @default.
- W2033415150 countsByYear W20334151502016 @default.
- W2033415150 countsByYear W20334151502017 @default.
- W2033415150 countsByYear W20334151502018 @default.
- W2033415150 countsByYear W20334151502021 @default.
- W2033415150 crossrefType "journal-article" @default.
- W2033415150 hasAuthorship W2033415150A5004588799 @default.
- W2033415150 hasAuthorship W2033415150A5005071062 @default.
- W2033415150 hasAuthorship W2033415150A5033959946 @default.
- W2033415150 hasAuthorship W2033415150A5041682827 @default.
- W2033415150 hasAuthorship W2033415150A5042144096 @default.
- W2033415150 hasAuthorship W2033415150A5047118448 @default.
- W2033415150 hasAuthorship W2033415150A5063582505 @default.
- W2033415150 hasAuthorship W2033415150A5083674171 @default.
- W2033415150 hasConcept C150903083 @default.
- W2033415150 hasConcept C178790620 @default.
- W2033415150 hasConcept C179464577 @default.
- W2033415150 hasConcept C181199279 @default.
- W2033415150 hasConcept C185592680 @default.
- W2033415150 hasConcept C202751555 @default.
- W2033415150 hasConcept C203014093 @default.
- W2033415150 hasConcept C207001950 @default.
- W2033415150 hasConcept C21951064 @default.
- W2033415150 hasConcept C2776090121 @default.