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- W2033434013 abstract "Increasing evidence indicates that the dysregulation of cell-cycle machinery may contribute to the development of cancer. During the past five years, our knowledge of the mechanisms that control cell proliferation has greatly increased with the identification of cell cycle regulating proteins namely cyclins, cyclin-dependent kinase (CDKs) and cyclin-dependent kinase inhibitors (CKIs). In this study we have investigated immunohistochemically the expression of cyclin D1, CKIs (p15, p16, and P27), p53 and related proteins (p21, MDM2), and apoptosis-suppressing protein bcl-2 in 20 cases of basal cell carcinomas (BCCs) and 20 cases of squamous cell carcinomas (SCCs). BCCs showed a moderate proliferative index with a comparable p53 nuclear expression and a diffuse and homogeneous cytoplasmic bcl-2 expression. Neoplastic cells expressed low level of p21 and cyclin D1; p15, p16, were expressed by isolated scattered cells. By contrast in SCCs the cell proliferation index and P53 expression were higher with a consistent p21 and cyclin D1 expression, more pronounced in SCCs poorly differentiated. A small percentage of SCCs cells were p16 positive, while bcl-2 was undetectable in most of the cases studied. These data suggest that the differential expression of several cell cycle proteins found in BCCs and SCCs may be responsable of the different biological behaviour of these tumours. Moreover the inverse correlation between bcl-2 expression and low level of p21 and p53 proteins in BCCs strongly suggests the capacity of bcl-2 to down- regulate the expression of specific pro-apoptotic proteins." @default.
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- W2033434013 date "1997-01-01" @default.
- W2033434013 modified "2023-09-24" @default.
- W2033434013 title "Immunohistochemical Evaluation of Cell Cycle Regulating Proteins in Epithelial Skin Tumors" @default.
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- W2033434013 doi "https://doi.org/10.1007/978-3-642-60771-4_95" @default.
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