Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033445087> ?p ?o ?g. }
Showing items 1 to 86 of
86
with 100 items per page.
- W2033445087 endingPage "873" @default.
- W2033445087 startingPage "868" @default.
- W2033445087 abstract "Beside lymphocytes and neutrophils, eosinophils are also involved in the inflammatory reaction in rheumatoid arthritis (RA). In this study, adhesion characteristics of peripheral blood eosinophils were studied in 43 RA patients and 19 controls, together with the expression of the beta2-integrin Mac-1 (CD11b/CD18). In addition, the production of oxygen radicals of isolated peripheral blood eosinophils and serum levels of eosinophil cationic protein (ECP) were measured in order to evaluate eosinophil activation. Adhesion of eosinophils to unstimulated human vascular endothelium was significantly higher in RA patients with active disease (n = 4) compared with controls (n = 14) (P < 0.005) and compared with patients with less active RA (n = 16) (P < 0.05). Nevertheless, the expression of the adhesion molecule Mac-1 (CD11b/CD18) was not increased in RA patients. ECP levels were higher in RA patients with active disease (P < 0.01). Release of oxygen radicals in response to phorbol stimulation was significantly elevated in active RA compared with controls (P < 0.05) and to less active RA (P < 0.05). We conclude that eosinophils of RA patients, especially those with active disease, are activated or at least primed and are involved in the inflammatory process in RA, analogous to the inflammation in asthma. The higher adhesion to inflamed endothelium is indicative of a higher infiltration in the joints, where tissue damage can be caused by toxic oxygen radicals and by granular proteins, such as ECP." @default.
- W2033445087 created "2016-06-24" @default.
- W2033445087 creator A5005164429 @default.
- W2033445087 creator A5025241185 @default.
- W2033445087 creator A5041256007 @default.
- W2033445087 creator A5075880317 @default.
- W2033445087 creator A5079609914 @default.
- W2033445087 date "1993-10-01" @default.
- W2033445087 modified "2023-09-27" @default.
- W2033445087 title "Study of eosinophil-endothelial adhesion, production of oxygen radicals and release of eosinophil cationic protein by peripheral blood eosinophils of patients with rheumatoid arthritis" @default.
- W2033445087 cites W1811625932 @default.
- W2033445087 cites W182697852 @default.
- W2033445087 cites W1973443459 @default.
- W2033445087 cites W1984888820 @default.
- W2033445087 cites W1994124852 @default.
- W2033445087 cites W2009955165 @default.
- W2033445087 cites W2024175969 @default.
- W2033445087 cites W2038365817 @default.
- W2033445087 cites W2043749764 @default.
- W2033445087 cites W2056178985 @default.
- W2033445087 cites W2072116944 @default.
- W2033445087 cites W2072181524 @default.
- W2033445087 cites W2078805607 @default.
- W2033445087 cites W2081018303 @default.
- W2033445087 cites W2081120186 @default.
- W2033445087 cites W2093885765 @default.
- W2033445087 cites W2100087148 @default.
- W2033445087 cites W2105573205 @default.
- W2033445087 cites W2157603347 @default.
- W2033445087 doi "https://doi.org/10.1111/j.1365-2222.1993.tb00266.x" @default.
- W2033445087 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/10780895" @default.
- W2033445087 hasPublicationYear "1993" @default.
- W2033445087 type Work @default.
- W2033445087 sameAs 2033445087 @default.
- W2033445087 citedByCount "12" @default.
- W2033445087 countsByYear W20334450872014 @default.
- W2033445087 countsByYear W20334450872021 @default.
- W2033445087 countsByYear W20334450872023 @default.
- W2033445087 crossrefType "journal-article" @default.
- W2033445087 hasAuthorship W2033445087A5005164429 @default.
- W2033445087 hasAuthorship W2033445087A5025241185 @default.
- W2033445087 hasAuthorship W2033445087A5041256007 @default.
- W2033445087 hasAuthorship W2033445087A5075880317 @default.
- W2033445087 hasAuthorship W2033445087A5079609914 @default.
- W2033445087 hasConcept C171779818 @default.
- W2033445087 hasConcept C203014093 @default.
- W2033445087 hasConcept C2776042228 @default.
- W2033445087 hasConcept C2776914184 @default.
- W2033445087 hasConcept C2777037409 @default.
- W2033445087 hasConcept C2777575956 @default.
- W2033445087 hasConcept C53122370 @default.
- W2033445087 hasConcept C71924100 @default.
- W2033445087 hasConcept C88675164 @default.
- W2033445087 hasConcept C8891405 @default.
- W2033445087 hasConceptScore W2033445087C171779818 @default.
- W2033445087 hasConceptScore W2033445087C203014093 @default.
- W2033445087 hasConceptScore W2033445087C2776042228 @default.
- W2033445087 hasConceptScore W2033445087C2776914184 @default.
- W2033445087 hasConceptScore W2033445087C2777037409 @default.
- W2033445087 hasConceptScore W2033445087C2777575956 @default.
- W2033445087 hasConceptScore W2033445087C53122370 @default.
- W2033445087 hasConceptScore W2033445087C71924100 @default.
- W2033445087 hasConceptScore W2033445087C88675164 @default.
- W2033445087 hasConceptScore W2033445087C8891405 @default.
- W2033445087 hasIssue "10" @default.
- W2033445087 hasLocation W20334450871 @default.
- W2033445087 hasLocation W20334450872 @default.
- W2033445087 hasOpenAccess W2033445087 @default.
- W2033445087 hasPrimaryLocation W20334450871 @default.
- W2033445087 hasRelatedWork W2026736544 @default.
- W2033445087 hasRelatedWork W2033445087 @default.
- W2033445087 hasRelatedWork W2038480770 @default.
- W2033445087 hasRelatedWork W2059423675 @default.
- W2033445087 hasRelatedWork W2080990123 @default.
- W2033445087 hasRelatedWork W2083938457 @default.
- W2033445087 hasRelatedWork W2093701159 @default.
- W2033445087 hasRelatedWork W2404282203 @default.
- W2033445087 hasRelatedWork W2415347800 @default.
- W2033445087 hasRelatedWork W35794083 @default.
- W2033445087 hasVolume "23" @default.
- W2033445087 isParatext "false" @default.
- W2033445087 isRetracted "false" @default.
- W2033445087 magId "2033445087" @default.
- W2033445087 workType "article" @default.