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- W2033447005 abstract "Cancer is the result of a combination of genetic alterations, which aid transformation of cells. However, oncogenic alterations also simultaneously induce some detrimental effects on the cells such as apoptosis, senescence, and differentiation. Such negative effects caused by certain oncogenic events are overcome by other cooperating genetic hits. We propose stem cell exhaustion as a novel detrimental effect that is caused by a wide variety of oncogenic alterations. Interestingly, in most cases, the stem cell exhaustion due to oncogenic alterations is preceded by an abnormal expansion of stem/progenitor cells. This preceding stem/progenitor cell expansion may be a key feature that still promotes cancer development, along with cooperating hits that rescue stem cell exhaustion. This review summarizes current knowledge about hematopoietic stem cell exhaustion and the mechanisms to overcome stem cell exhaustion in cancer development." @default.
- W2033447005 created "2016-06-24" @default.
- W2033447005 creator A5040569631 @default.
- W2033447005 creator A5048529768 @default.
- W2033447005 date "2009-06-01" @default.
- W2033447005 modified "2023-10-01" @default.
- W2033447005 title "Stem cell exhaustion and leukemogenesis" @default.
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- W2033447005 doi "https://doi.org/10.1002/jcb.22150" @default.
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