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• W2033447440 endingPage "418" @default.
• W2033447440 startingPage "408" @default.
• W2033447440 abstract "•Non-immunoglobulin (non-Ig) scaffolds are small antibody alternatives. •139 binders of 20 different non-Ig scaffold types have been developed against 102 different targets. •Their main application is in the treatment and diagnosis of cancer and inflammatory diseases. •They can also be used in structural studies and post-translational modification monitoring. Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain proteins that require no post-translational modification, often lack disulfide bonds, and can undergo straightforward multimerization. Among the 20 different types of non-Ig scaffolds, Adhirons, Alphabodies, Centyrins, Pronectins, Repebodies, Affimers, and Obodies have been introduced in the past 4 years. 102 proteins have been specifically targeted by 139 different non-Ig scaffold binders. The most frequent application of non-Ig scaffolds is in the treatment and diagnosis of cancer and inflammatory diseases, and 10 non-Ig scaffolds have already been tested in clinical trials. Recently, non-Ig scaffolds have often been used in research as structure determination chaperones, for intracellular monitoring of post-translational modifications, and as antibody alternatives for microscopy, flow cytometry, and Western blotting. Non-immunoglobulin (non-Ig) scaffolds are, in contrast to antibodies, small single-domain proteins that require no post-translational modification, often lack disulfide bonds, and can undergo straightforward multimerization. Among the 20 different types of non-Ig scaffolds, Adhirons, Alphabodies, Centyrins, Pronectins, Repebodies, Affimers, and Obodies have been introduced in the past 4 years. 102 proteins have been specifically targeted by 139 different non-Ig scaffold binders. The most frequent application of non-Ig scaffolds is in the treatment and diagnosis of cancer and inflammatory diseases, and 10 non-Ig scaffolds have already been tested in clinical trials. Recently, non-Ig scaffolds have often been used in research as structure determination chaperones, for intracellular monitoring of post-translational modifications, and as antibody alternatives for microscopy, flow cytometry, and Western blotting." @default.
• W2033447440 created "2016-06-24" @default.
• W2033447440 creator A5054215167 @default.
• W2033447440 creator A5067789182 @default.
• W2033447440 creator A5071586144 @default.
• W2033447440 date "2015-07-01" @default.
• W2033447440 modified "2023-10-12" @default.
• W2033447440 title "Non-immunoglobulin scaffolds: a focus on their targets" @default.
• W2033447440 cites W1534782054 @default.
• W2033447440 cites W1580407891 @default.
• W2033447440 cites W1859509310 @default.
• W2033447440 cites W1878979072 @default.
• W2033447440 cites W1963903021 @default.
• W2033447440 cites W1964042467 @default.
• W2033447440 cites W1965706807 @default.
• W2033447440 cites W1969900252 @default.
• W2033447440 cites W1971619188 @default.
• W2033447440 cites W1972488385 @default.
• W2033447440 cites W1977315164 @default.
• W2033447440 cites W1982535535 @default.
• W2033447440 cites W1984161641 @default.
• W2033447440 cites W1986783732 @default.
• W2033447440 cites W1989588669 @default.
• W2033447440 cites W1990575572 @default.
• W2033447440 cites W1991306710 @default.
• W2033447440 cites W1991929388 @default.
• W2033447440 cites W1994228699 @default.
• W2033447440 cites W1997874766 @default.
• W2033447440 cites W1999587638 @default.
• W2033447440 cites W2001324434 @default.
• W2033447440 cites W2001784729 @default.
• W2033447440 cites W2004847312 @default.
• W2033447440 cites W2008635725 @default.
• W2033447440 cites W2008925833 @default.
• W2033447440 cites W2010438788 @default.
• W2033447440 cites W2013360127 @default.
• W2033447440 cites W2020633470 @default.
• W2033447440 cites W2022589561 @default.
• W2033447440 cites W2025951140 @default.
• W2033447440 cites W2027005522 @default.
• W2033447440 cites W2027155177 @default.
• W2033447440 cites W2027268124 @default.
• W2033447440 cites W2028415754 @default.
• W2033447440 cites W2038911909 @default.
• W2033447440 cites W2042717319 @default.
• W2033447440 cites W2045132978 @default.
• W2033447440 cites W2045384297 @default.
• W2033447440 cites W2045650397 @default.
• W2033447440 cites W2047199560 @default.
• W2033447440 cites W2050604916 @default.
• W2033447440 cites W2051287873 @default.
• W2033447440 cites W2053214209 @default.
• W2033447440 cites W2055798713 @default.
• W2033447440 cites W2056230130 @default.
• W2033447440 cites W2057520802 @default.
• W2033447440 cites W2062797193 @default.
• W2033447440 cites W2063593859 @default.
• W2033447440 cites W2076051069 @default.
• W2033447440 cites W2077787026 @default.
• W2033447440 cites W2084938664 @default.
• W2033447440 cites W2085484793 @default.
• W2033447440 cites W2092114953 @default.
• W2033447440 cites W2096836753 @default.
• W2033447440 cites W2099505037 @default.
• W2033447440 cites W2099641930 @default.
• W2033447440 cites W2099851537 @default.
• W2033447440 cites W2099932018 @default.
• W2033447440 cites W2100274686 @default.
• W2033447440 cites W2102513863 @default.
• W2033447440 cites W2111481626 @default.
• W2033447440 cites W2113873088 @default.
• W2033447440 cites W2120117770 @default.
• W2033447440 cites W2120374132 @default.
• W2033447440 cites W2123000304 @default.
• W2033447440 cites W2125722613 @default.
• W2033447440 cites W2127368222 @default.
• W2033447440 cites W2128130662 @default.
• W2033447440 cites W2130636562 @default.
• W2033447440 cites W2130678936 @default.
• W2033447440 cites W2131312664 @default.
• W2033447440 cites W2131443651 @default.
• W2033447440 cites W2136802861 @default.
• W2033447440 cites W2137170183 @default.
• W2033447440 cites W2141002805 @default.
• W2033447440 cites W2148101159 @default.
• W2033447440 cites W2149825079 @default.
• W2033447440 cites W2151813007 @default.
• W2033447440 cites W2151856262 @default.
• W2033447440 cites W2152599849 @default.
• W2033447440 cites W2158500698 @default.
• W2033447440 cites W2160125502 @default.
• W2033447440 cites W2162380908 @default.
• W2033447440 cites W2162793769 @default.
• W2033447440 cites W2163234860 @default.
• W2033447440 cites W2164148522 @default.
• W2033447440 cites W2164452916 @default.
• W2033447440 cites W2165238581 @default.
• W2033447440 cites W2165431995 @default.

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