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- W2033460919 endingPage "436" @default.
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- W2033460919 abstract "Previous studies have shown that Foxc1 and Foxc2 , closely related Fox transcription factors, have interactive roles in cardiovascular development. However, little is known about their functional overlap during early heart morphogenesis. Here, we show that Foxc genes are coexpressed in a novel heart field, the second heart field, as well as the cardiac neural crest cells (NCCs), endocardium, and proepicardium. Notably, compound Foxc1 ; Foxc2 mutants have a wide spectrum of cardiac abnormalities, including hypoplasia or lack of the outflow tract (OFT) and right ventricle as well as the inflow tract, dysplasia of the OFT and atrioventricular cushions, and abnormal formation of the epicardium, in a dose-dependent manner. Most importantly, in the second heart field, compound mutants exhibit significant downregulation of Tbx1 and Fgf8 / 10 and a reduction in cell proliferation. Moreover, NCCs in compound mutants show extensive apoptosis during migration, leading to a failure of the OFT septation. Taken together, our results demonstrate that Foxc1 and Foxc2 play pivotal roles in the early processes of heart development, especially acting upstream of the Tbx1-FGF cascade during the morphogenesis of the OFT." @default.
- W2033460919 created "2016-06-24" @default.
- W2033460919 creator A5019191395 @default.
- W2033460919 creator A5045308696 @default.
- W2033460919 date "2006-08-01" @default.
- W2033460919 modified "2023-10-18" @default.
- W2033460919 title "Forkhead transcription factors, Foxc1 and Foxc2, are required for the morphogenesis of the cardiac outflow tract" @default.
- W2033460919 cites W1570267305 @default.
- W2033460919 cites W1575984269 @default.
- W2033460919 cites W1765845624 @default.
- W2033460919 cites W1826330550 @default.
- W2033460919 cites W1931060259 @default.
- W2033460919 cites W1937613866 @default.
- W2033460919 cites W1955467086 @default.
- W2033460919 cites W1966312815 @default.
- W2033460919 cites W1966397938 @default.
- W2033460919 cites W1966563415 @default.
- W2033460919 cites W1967125902 @default.
- W2033460919 cites W1971977081 @default.
- W2033460919 cites W1973755623 @default.
- W2033460919 cites W1974261580 @default.
- W2033460919 cites W1983026860 @default.
- W2033460919 cites W1985938739 @default.
- W2033460919 cites W1988309701 @default.
- W2033460919 cites W1988925093 @default.
- W2033460919 cites W1991375522 @default.
- W2033460919 cites W1992273810 @default.
- W2033460919 cites W1993827678 @default.
- W2033460919 cites W1993913999 @default.
- W2033460919 cites W1994142299 @default.
- W2033460919 cites W1998261642 @default.
- W2033460919 cites W2002228001 @default.
- W2033460919 cites W2002732720 @default.
- W2033460919 cites W2003461650 @default.
- W2033460919 cites W2003959047 @default.
- W2033460919 cites W2004824962 @default.
- W2033460919 cites W2008241074 @default.
- W2033460919 cites W2011237068 @default.
- W2033460919 cites W2011884985 @default.
- W2033460919 cites W2012517517 @default.
- W2033460919 cites W2015082418 @default.
- W2033460919 cites W2021052173 @default.
- W2033460919 cites W2025425480 @default.
- W2033460919 cites W2031650663 @default.
- W2033460919 cites W2034977717 @default.
- W2033460919 cites W2040016657 @default.
- W2033460919 cites W2050880646 @default.
- W2033460919 cites W2051026229 @default.
- W2033460919 cites W2053680680 @default.
- W2033460919 cites W2053797631 @default.
- W2033460919 cites W2054191145 @default.
- W2033460919 cites W2068801415 @default.
- W2033460919 cites W2069126410 @default.
- W2033460919 cites W2070298717 @default.
- W2033460919 cites W2073615403 @default.
- W2033460919 cites W2074220434 @default.
- W2033460919 cites W2075396495 @default.
- W2033460919 cites W2075401648 @default.
- W2033460919 cites W2076007521 @default.
- W2033460919 cites W2078387767 @default.
- W2033460919 cites W2082403352 @default.
- W2033460919 cites W2088906649 @default.
- W2033460919 cites W2090056454 @default.
- W2033460919 cites W2097803027 @default.
- W2033460919 cites W2102258222 @default.
- W2033460919 cites W2105985098 @default.
- W2033460919 cites W2106827802 @default.
- W2033460919 cites W2107793848 @default.
- W2033460919 cites W2111122566 @default.
- W2033460919 cites W2115833670 @default.
- W2033460919 cites W2118046629 @default.
- W2033460919 cites W2126261367 @default.
- W2033460919 cites W2137058559 @default.
- W2033460919 cites W2138053255 @default.
- W2033460919 cites W2138354687 @default.
- W2033460919 cites W2138467380 @default.
- W2033460919 cites W2139265039 @default.
- W2033460919 cites W2140279570 @default.
- W2033460919 cites W2148037744 @default.
- W2033460919 cites W2151504171 @default.
- W2033460919 cites W2155956254 @default.
- W2033460919 cites W2156061910 @default.
- W2033460919 cites W2157304951 @default.
- W2033460919 cites W2157592788 @default.
- W2033460919 cites W2158378290 @default.
- W2033460919 cites W2158591109 @default.
- W2033460919 cites W2159443353 @default.
- W2033460919 cites W2160907451 @default.
- W2033460919 cites W2164108959 @default.
- W2033460919 cites W2168192071 @default.
- W2033460919 cites W2171952998 @default.
- W2033460919 doi "https://doi.org/10.1016/j.ydbio.2006.06.012" @default.
- W2033460919 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16839542" @default.
- W2033460919 hasPublicationYear "2006" @default.
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