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- W2033461575 abstract "Intravenous injection of labetalol induced an immediate fall (-22.4%) in blood pressure (BP) in 11 patients with severe hypertension. Hypotensive episodes were avoided by repeated injections of 0.2-0.8 mg/kg. The pressure reduction was associated with a mean fall in total peripheral resistance of 13.6%. Cardiac output fell 10.1% owing to a fall in heart rate of 10.8%, while stroke volume remained virtually unchanged. Despite excellent acute control of BP by intravenous injection, oral labetalol alone or in combination with hydrochlorothiazide was not effective in long-term treatment of these patients with severe hypertension. After 1 week, mean arterial pressure was still 10.4% below the pretreatment level, but after 4 months BP was back to pretreatment level in all except one patient whose BP is still well controlled after more than 2 years on labetalol." @default.
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- W2033461575 date "1982-11-01" @default.
- W2033461575 modified "2023-09-25" @default.
- W2033461575 title "Acute Hemodynamic Effects of Labetalol in Severe Hypertension" @default.
- W2033461575 doi "https://doi.org/10.1097/00005344-198211000-00006" @default.
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