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- W2033465937 abstract "Cytochrome P450 (CYP) gene expression in the livers of mice with concanavalin A-induced hepatitis was examined. Treatment of mice with concanavalin A (10 mg/kg, i.v.) elevated plasma alanine aminotransaminase activity. In normal liver, CYP1A2, 3A and 2E1 mRNAs were expressed, and concanavalin A treatment differentially suppressed the expression of these CYP genes. Gadolinium chloride (40 mg/kg, i.p.) treatment, which inhibited the concanavalin A-induced elevation of plasma alanine aminotransferase activity without affecting concanavalin A-induced cytokine expression, counteracted the concanavalin A-induced suppression of CYP gene expression in the liver. Kupffer cell function or hepatic injury might contribute to the concanavalin A-induced suppression of CYP gene expression." @default.
- W2033465937 created "2016-06-24" @default.
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- W2033465937 date "2000-04-01" @default.
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- W2033465937 title "Suppression of cytochrome P450 gene expression in the livers of mice with concanavalin A-induced hepatitis" @default.
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- W2033465937 doi "https://doi.org/10.1016/s0014-2999(00)00134-5" @default.
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