Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033474198> ?p ?o ?g. }
- W2033474198 endingPage "71" @default.
- W2033474198 startingPage "58" @default.
- W2033474198 abstract "Mammalian melanoma differentiation-associated gene-5 (MDA5) and retinoic acid-inducible gene-I (RIG-I) selectively sense double-stranded RNA (dsRNA) according to length, as well as various RNA viruses to induce an antiviral response. RIG-I, which plays a predominant role in the induction of antiviral responses against influenza virus infection, has been considered to be lacking in chicken, putting the function of chicken MDA5 (chMDA5) under the spotlight. Here, we show that chMDA5, unlike mammalian MDA5, preferentially senses shorter dsRNA synthetic analogues, poly(I:C), in chicken DF-1 fibroblasts. A requirement for caspase activation and recruitment domains for chMDA5-mediated chicken interferon beta (chIFNβ) induction and its interaction with mitochondrial antiviral signaling proteins were demonstrated. We also found that chMDA5 is involved in chIFNβ induction against avian influenza virus infection. Our findings imply that chMDA5 compensates in part the function of RIG-I in chicken, and highlights the importance of chMDA5 in the innate immune response in chicken." @default.
- W2033474198 created "2016-06-24" @default.
- W2033474198 creator A5007108776 @default.
- W2033474198 creator A5027132861 @default.
- W2033474198 creator A5037906660 @default.
- W2033474198 creator A5040408001 @default.
- W2033474198 creator A5064526541 @default.
- W2033474198 creator A5090036239 @default.
- W2033474198 date "2013-07-13" @default.
- W2033474198 modified "2023-10-10" @default.
- W2033474198 title "Chicken MDA5 Senses Short Double-Stranded RNA with Implications for Antiviral Response against Avian Influenza Viruses in Chicken" @default.
- W2033474198 cites W1968902673 @default.
- W2033474198 cites W1977991935 @default.
- W2033474198 cites W1979838502 @default.
- W2033474198 cites W1987311941 @default.
- W2033474198 cites W1992192767 @default.
- W2033474198 cites W1993981839 @default.
- W2033474198 cites W2000347944 @default.
- W2033474198 cites W2004312418 @default.
- W2033474198 cites W2009127910 @default.
- W2033474198 cites W2014666163 @default.
- W2033474198 cites W2016194523 @default.
- W2033474198 cites W2017515700 @default.
- W2033474198 cites W2023610143 @default.
- W2033474198 cites W2028012273 @default.
- W2033474198 cites W2028575270 @default.
- W2033474198 cites W2034653488 @default.
- W2033474198 cites W2035317074 @default.
- W2033474198 cites W2037502650 @default.
- W2033474198 cites W2037923342 @default.
- W2033474198 cites W2046597456 @default.
- W2033474198 cites W2051206691 @default.
- W2033474198 cites W2062490839 @default.
- W2033474198 cites W2069375901 @default.
- W2033474198 cites W2070308943 @default.
- W2033474198 cites W2073238379 @default.
- W2033474198 cites W2107277218 @default.
- W2033474198 cites W2107458751 @default.
- W2033474198 cites W2110214166 @default.
- W2033474198 cites W2114048032 @default.
- W2033474198 cites W2116776033 @default.
- W2033474198 cites W2119492463 @default.
- W2033474198 cites W2120483717 @default.
- W2033474198 cites W2124284032 @default.
- W2033474198 cites W2125566625 @default.
- W2033474198 cites W2126982616 @default.
- W2033474198 cites W2138408665 @default.
- W2033474198 cites W2140815975 @default.
- W2033474198 cites W2145096265 @default.
- W2033474198 cites W2148985310 @default.
- W2033474198 cites W2151460035 @default.
- W2033474198 doi "https://doi.org/10.1159/000351583" @default.
- W2033474198 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6741575" @default.
- W2033474198 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23860388" @default.
- W2033474198 hasPublicationYear "2013" @default.
- W2033474198 type Work @default.
- W2033474198 sameAs 2033474198 @default.
- W2033474198 citedByCount "56" @default.
- W2033474198 countsByYear W20334741982015 @default.
- W2033474198 countsByYear W20334741982016 @default.
- W2033474198 countsByYear W20334741982017 @default.
- W2033474198 countsByYear W20334741982018 @default.
- W2033474198 countsByYear W20334741982019 @default.
- W2033474198 countsByYear W20334741982020 @default.
- W2033474198 countsByYear W20334741982021 @default.
- W2033474198 countsByYear W20334741982022 @default.
- W2033474198 countsByYear W20334741982023 @default.
- W2033474198 crossrefType "journal-article" @default.
- W2033474198 hasAuthorship W2033474198A5007108776 @default.
- W2033474198 hasAuthorship W2033474198A5027132861 @default.
- W2033474198 hasAuthorship W2033474198A5037906660 @default.
- W2033474198 hasAuthorship W2033474198A5040408001 @default.
- W2033474198 hasAuthorship W2033474198A5064526541 @default.
- W2033474198 hasAuthorship W2033474198A5090036239 @default.
- W2033474198 hasBestOaLocation W20334741982 @default.
- W2033474198 hasConcept C104317684 @default.
- W2033474198 hasConcept C134474686 @default.
- W2033474198 hasConcept C136449434 @default.
- W2033474198 hasConcept C159047783 @default.
- W2033474198 hasConcept C166703698 @default.
- W2033474198 hasConcept C2191507 @default.
- W2033474198 hasConcept C2522874641 @default.
- W2033474198 hasConcept C2776178377 @default.
- W2033474198 hasConcept C2776746152 @default.
- W2033474198 hasConcept C2776954689 @default.
- W2033474198 hasConcept C2777546802 @default.
- W2033474198 hasConcept C519248777 @default.
- W2033474198 hasConcept C54355233 @default.
- W2033474198 hasConcept C67705224 @default.
- W2033474198 hasConcept C86803240 @default.
- W2033474198 hasConcept C8891405 @default.
- W2033474198 hasConceptScore W2033474198C104317684 @default.
- W2033474198 hasConceptScore W2033474198C134474686 @default.
- W2033474198 hasConceptScore W2033474198C136449434 @default.
- W2033474198 hasConceptScore W2033474198C159047783 @default.
- W2033474198 hasConceptScore W2033474198C166703698 @default.
- W2033474198 hasConceptScore W2033474198C2191507 @default.
- W2033474198 hasConceptScore W2033474198C2522874641 @default.