FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033491189> ?p ?o ?g. }

• W2033491189 endingPage "571" @default.
• W2033491189 startingPage "555" @default.
• W2033491189 abstract "Previous studies have suggested that activation of nociceptive afferents from the heel recruits a supraspinal mechanism, which is modulated by adrenergic descending inhibition, that augments withdrawal reflexes in medial gastrocnemius (MG) motoneurones. To test this idea, we have studied the temporal evolution of reflexes evoked in MG by electrical stimulation of sural nerve Aβ-, Aδ- and C-fibre axons at 1 Hz, in decerebrated rabbits. Reflexes were analysed in three time bands, estimated to accord to afferent drive from Aβ- (phase 1), Aδ- (phase 2) and C-fibre (phase 3) inputs. Stimulation of Aδ- and C-fibres gave significant temporal summation of all reflexes. The α2-adrenoceptor antagonist RX 821002 ((2-(2,3-dihydro-2-methoxy-1,4-benzodioxin-2-yl)-4,5-dihydro-1-H-imidazole)–HCl) (100 μg intrathecal (i.t.)) potentiated, and the α2-agonist dexmedetomidine (1–30 μg i.t.) depressed all reflexes per se, but the effects of these drugs on temporal summation were secondary to changes in baseline excitability. When C-fibres were stimulated, the N-methyl-D-aspartate (NMDA) receptor antagonist dizocilpine (1 mg i.t.) reduced temporal summation of phase 2 and 3 but not phase 1 reflexes. Spinalisation at L1 in the absence of drugs increased phase 2 and 3 reflexes but had no effect on phase 1, whereas spinalisation after RX 821002 resulted in decreased phase 1 responses with no significant change in later phases. Spinalisation in the presence of dizocilpine resulted in small reductions in phase 3 reflexes only. In all cases spinalisation virtually abolished temporal summation. In spinalised animals, dizocilpine selectively reduced late reflexes, and the opioid antagonist naloxone (100 μg i.t.) augmented all reflexes but gave rise to temporal subtraction of reflexes when C-fibres were stimulated. The present experiments have revealed a number of novel and important features of the sural–MG reflex pathway: (i) activity in fine afferent axons augments the reflexogenic potential of all subsequent afferent input, thereby allowing all afferent drive from the sural field to contribute to withdrawal of the heel; (ii) endogenous adrenergic control of this reflex pathway is completely non-selective; (iii) there is a non-adrenergic element of descending inhibition that is selective for the late components of MG reflex responses, and this element is directed particularly against transmission through NMDA receptors; (iv) temporal summation in this reflex is dependent on NMDA receptor-dependent and -independent mechanisms; and (v) this temporal summation is in some way dependent on the integrity of descending pathways." @default.
• W2033491189 created "2016-06-24" @default.
• W2033491189 creator A5032355536 @default.
• W2033491189 creator A5054133484 @default.
• W2033491189 creator A5058157189 @default.
• W2033491189 creator A5066469575 @default.
• W2033491189 creator A5079769178 @default.
• W2033491189 date "2002-07-01" @default.
• W2033491189 modified "2023-09-27" @default.
• W2033491189 title "Interactions between cutaneous afferent inputs to a withdrawal reflex in the decerebrated rabbit and their control by descending and segmental systems" @default.
• W2033491189 cites W1455487048 @default.
• W2033491189 cites W1573831774 @default.
• W2033491189 cites W1691247107 @default.
• W2033491189 cites W1964810360 @default.
• W2033491189 cites W1970258740 @default.
• W2033491189 cites W1970618945 @default.
• W2033491189 cites W1978896524 @default.
• W2033491189 cites W1988713782 @default.
• W2033491189 cites W1993697980 @default.
• W2033491189 cites W1994063237 @default.
• W2033491189 cites W1994201515 @default.
• W2033491189 cites W1995232241 @default.
• W2033491189 cites W1995857215 @default.
• W2033491189 cites W2002901944 @default.
• W2033491189 cites W2003066952 @default.
• W2033491189 cites W2006326683 @default.
• W2033491189 cites W2006490359 @default.
• W2033491189 cites W2014779151 @default.
• W2033491189 cites W2014926098 @default.
• W2033491189 cites W2015617592 @default.
• W2033491189 cites W2019382248 @default.
• W2033491189 cites W2020428188 @default.
• W2033491189 cites W2021508694 @default.
• W2033491189 cites W2022317103 @default.
• W2033491189 cites W2022898812 @default.
• W2033491189 cites W2023011608 @default.
• W2033491189 cites W2031206794 @default.
• W2033491189 cites W2032159951 @default.
• W2033491189 cites W2038163667 @default.
• W2033491189 cites W2038469842 @default.
• W2033491189 cites W2038658827 @default.
• W2033491189 cites W2042907111 @default.
• W2033491189 cites W2043356561 @default.
• W2033491189 cites W2047739001 @default.
• W2033491189 cites W2049695557 @default.
• W2033491189 cites W2051318074 @default.
• W2033491189 cites W2055535637 @default.
• W2033491189 cites W2057870229 @default.
• W2033491189 cites W2062526456 @default.
• W2033491189 cites W2064292441 @default.
• W2033491189 cites W2071715974 @default.
• W2033491189 cites W2084461986 @default.
• W2033491189 cites W2084718623 @default.
• W2033491189 cites W2086475877 @default.
• W2033491189 cites W2090981990 @default.
• W2033491189 cites W2093647149 @default.
• W2033491189 cites W2119475844 @default.
• W2033491189 cites W2128449603 @default.
• W2033491189 cites W2137313067 @default.
• W2033491189 cites W2148733966 @default.
• W2033491189 cites W2163197552 @default.
• W2033491189 cites W2167563378 @default.
• W2033491189 cites W2321150685 @default.
• W2033491189 cites W2341225431 @default.
• W2033491189 cites W2398054166 @default.
• W2033491189 cites W2468424440 @default.
• W2033491189 cites W4243836117 @default.
• W2033491189 cites W4300481397 @default.
• W2033491189 doi "https://doi.org/10.1016/s0306-4522(02)00093-3" @default.
• W2033491189 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/12074898" @default.
• W2033491189 hasPublicationYear "2002" @default.
• W2033491189 type Work @default.
• W2033491189 sameAs 2033491189 @default.
• W2033491189 citedByCount "42" @default.
• W2033491189 countsByYear W20334911892012 @default.
• W2033491189 countsByYear W20334911892013 @default.
• W2033491189 countsByYear W20334911892014 @default.
• W2033491189 countsByYear W20334911892015 @default.
• W2033491189 countsByYear W20334911892016 @default.
• W2033491189 countsByYear W20334911892017 @default.
• W2033491189 countsByYear W20334911892018 @default.
• W2033491189 countsByYear W20334911892019 @default.
• W2033491189 countsByYear W20334911892022 @default.
• W2033491189 countsByYear W20334911892023 @default.
• W2033491189 crossrefType "journal-article" @default.
• W2033491189 hasAuthorship W2033491189A5032355536 @default.
• W2033491189 hasAuthorship W2033491189A5054133484 @default.
• W2033491189 hasAuthorship W2033491189A5058157189 @default.
• W2033491189 hasAuthorship W2033491189A5066469575 @default.
• W2033491189 hasAuthorship W2033491189A5079769178 @default.
• W2033491189 hasConcept C126322002 @default.
• W2033491189 hasConcept C134018914 @default.
• W2033491189 hasConcept C15490471 @default.
• W2033491189 hasConcept C15744967 @default.
• W2033491189 hasConcept C169760540 @default.
• W2033491189 hasConcept C170493617 @default.
• W2033491189 hasConcept C185592680 @default.
• W2033491189 hasConcept C195512701 @default.

• next