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- W2033494511 abstract "The metabolism, in vitro, of [3H]-estrone, [3H]-estradiol-17 beta and [13H]-estrone-3-sulfate by the livers of pregnant, young virgin female and female fetus guinea-pigs has been compared using 900 g supernatants and microsomes. The ability of the guinea-pig livers to synthesize polyhydroxylated estrogens has been fo-nd to be small. The major metabolites isolated were unconjugated estrone and estradiol-17 beta or their glucuronides. The percentage of sulfates was lower after incubations with [3H]-estrone than with [3H]-estradiol-17 beta. A kinetic study with microsomes has shown a direct conversin of estrone-sulfate to estradiol sulfate. Fetal microsomes have been found to exhibit a more active hydrogenation of estrone to estradiol-17 beta than microsomes from young female or pregnant animals." @default.
- W2033494511 created "2016-06-24" @default.
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- W2033494511 date "1979-01-01" @default.
- W2033494511 modified "2023-09-26" @default.
- W2033494511 title "A comparison of the in vitro metabolism of estrone, estradiol-17β and estrone-3-sulfate by the livers of young virgin female, pregnant and female fetal guinea-pigs" @default.
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- W2033494511 doi "https://doi.org/10.1016/0039-128x(79)90135-1" @default.
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