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- W2033498005 abstract "PURPOSE: The phosphodiesterase-4 inhibitor roflumilast was approved by the FDA to reduce the risk of exacerbations in COPD patients with severe disease, chronic bronchitis and a history of acute exacerbations. This safety evaluation of 8 studies enrolled patients that were representative of the anticipated approval population receiving 500µg of roflumilast. By focusing on these 8 studies, this analysis may have improved relevance and sensitivity for adverse event (AE) frequencies, compared to previously reported broader multiple-dose safety pool results." @default.
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- W2033498005 date "2011-10-01" @default.
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- W2033498005 title "Pooled Safety of Roflumilast and Focus on Gastrointestinal Events in Eight Placebo-Controlled Studies in Patients With Chronic Obstructive Pulmonary Disease" @default.
- W2033498005 doi "https://doi.org/10.1378/chest.1115658" @default.
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