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- W2033501722 abstract "The model of experimental tumors of the nervous system has greatly contributed to our understanding of growth and management of intracranial tumors, but has been somewhat neglected in the last years, because a wealth of new data concerning oncogenic action came from viral oncogenesis. These new issues led to a much better insight into human tumor induction and promotion. Yet one example of the impact of oncogenic transformation stems from the neurooncogenic model: the discovery of the neu oncogene and its product as a putative differentiation receptor in the cell membrane of experimental Schwann cell derived tumors. In the light of this unique finding the history of the neurooncogenic model and the morphological and clinical result of tumors produced within the model are reviewed. There is a large open field for future investigation both in basic and applied science." @default.
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- W2033501722 date "1994-01-01" @default.
- W2033501722 modified "2023-10-16" @default.
- W2033501722 title "Chemical carcinogenesis in the nervous system: past and future" @default.
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- W2033501722 doi "https://doi.org/10.1016/s0940-2993(11)80504-x" @default.
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