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- W2033506468 abstract "Neuropeptide K (NPK), a member of the kassinin-like tachykinin family, is contained in the rat hypothalamus and is known to stimulate pituitary ACTH release. The intraperitoneal bolus administration of NPK dose-dependently enhanced corticosterone blood level not only in intact rats, but also in hypophysectomized/ACTH replaced animals. NPK did not affect corticosterone secretion of dispersed rat adrenocortical cells: however, it concentration-dependently raised basal corticosterone production by decapsulated adrenal quarters (including both cortical and medullary tissues). Minimal and maximal effective concentrations were 10−9 and 10−8 M, respectively. 10−8 M NPK potentiated corticosterone response of adrenal quarters elicited by 10−12 M ACTH, but not that evoked by higher concentrations of ACTH. The direct corticosterone secretagogue effect of 10−8 M NPK is annulled by 10−6 M α-helical-CRH or corticotropin-inhibiting peptide, competitive inhibitors of CRH and ACTH, respectively. In light of these findings, the hypothesis is advanced that NPK exerts a direct stimulatory action on adrenocortical secretion and that the mechanism underlying this effect of NPK may involve the activation of the intra-medullary CRH/ACTH system." @default.
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- W2033506468 date "1994-10-01" @default.
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- W2033506468 title "Neuropeptide K enhances glucocorticoid release by acting directly on the rat adrenal gland: the possible involvement of zona medullaris" @default.
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- W2033506468 doi "https://doi.org/10.1016/0006-8993(94)91185-1" @default.
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