Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033508008> ?p ?o ?g. }
Showing items 1 to 96 of
96
with 100 items per page.
- W2033508008 endingPage "1112" @default.
- W2033508008 startingPage "1105" @default.
- W2033508008 abstract "The antitumor activity and toxicity of two new 1-β-d-arabinofuranosylcytosine (ara-C) conjugates of cortisol and corticosterone linked through a phosphodiester bond between the 5′ and 21 positions of the respective moieties (cortisol- and corticosterone-p-ara-C) were investigated in L1210 lymphoid leukemia cells in mice. They are highly active against both i.p.- and i.c.-implanted ara-C-sensitive lymphoid leukemia in mice, exceeding the activity produced by the parent drug, ara-C. For example, corticosterone-p-ara-C exhibited the respective ILS values of 306% at 50 mg/kg/day × 9 and 294% at 75 mg/kg/day × 9 on survivals of i.p.- and i.c.-inoculated L1210 leukemic mice. The effectiveness of the conjugates seems to depend on schedules of the treatments. The 9-day continuous treatments showed a better therapeutic effectiveness than those with either a 5-day, a single or a widely spaced (q 4 d., 1, 5, 9) treatment. However, they were found to be marginally effective against i.p.-implanted ara-C-resistant L1210 leukemia in mice. They were also inhibitory against proliferation of human leukemia-lymphoid cells in culture. Their superior antitumor activity and resistance to cytidine deaminase suggests that they serve as a prodrug form of ara-C or ara-CMP." @default.
- W2033508008 created "2016-06-24" @default.
- W2033508008 creator A5029640572 @default.
- W2033508008 creator A5040909316 @default.
- W2033508008 creator A5062958747 @default.
- W2033508008 creator A5065353758 @default.
- W2033508008 creator A5075873868 @default.
- W2033508008 date "1983-08-01" @default.
- W2033508008 modified "2023-10-16" @default.
- W2033508008 title "1-β-d-Arabinofuranosylcytosine conjugates of corticosteroids as potential antitumor agents" @default.
- W2033508008 cites W1497704670 @default.
- W2033508008 cites W1508244085 @default.
- W2033508008 cites W1764679967 @default.
- W2033508008 cites W2013797678 @default.
- W2033508008 cites W2019876553 @default.
- W2033508008 cites W2020298904 @default.
- W2033508008 cites W2026552058 @default.
- W2033508008 cites W2039481939 @default.
- W2033508008 cites W2051510417 @default.
- W2033508008 cites W2054027055 @default.
- W2033508008 cites W2159181202 @default.
- W2033508008 cites W2328974800 @default.
- W2033508008 cites W2336886126 @default.
- W2033508008 cites W2414061408 @default.
- W2033508008 cites W2949439813 @default.
- W2033508008 cites W2953136898 @default.
- W2033508008 doi "https://doi.org/10.1016/0277-5379(83)90035-4" @default.
- W2033508008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/6684555" @default.
- W2033508008 hasPublicationYear "1983" @default.
- W2033508008 type Work @default.
- W2033508008 sameAs 2033508008 @default.
- W2033508008 citedByCount "5" @default.
- W2033508008 crossrefType "journal-article" @default.
- W2033508008 hasAuthorship W2033508008A5029640572 @default.
- W2033508008 hasAuthorship W2033508008A5040909316 @default.
- W2033508008 hasAuthorship W2033508008A5062958747 @default.
- W2033508008 hasAuthorship W2033508008A5065353758 @default.
- W2033508008 hasAuthorship W2033508008A5075873868 @default.
- W2033508008 hasConcept C108215921 @default.
- W2033508008 hasConcept C109316439 @default.
- W2033508008 hasConcept C126322002 @default.
- W2033508008 hasConcept C181199279 @default.
- W2033508008 hasConcept C185592680 @default.
- W2033508008 hasConcept C202751555 @default.
- W2033508008 hasConcept C2776985229 @default.
- W2033508008 hasConcept C2778397455 @default.
- W2033508008 hasConcept C2778461978 @default.
- W2033508008 hasConcept C2780017796 @default.
- W2033508008 hasConcept C2780352252 @default.
- W2033508008 hasConcept C2781059491 @default.
- W2033508008 hasConcept C2781184954 @default.
- W2033508008 hasConcept C55493867 @default.
- W2033508008 hasConcept C71315377 @default.
- W2033508008 hasConcept C71924100 @default.
- W2033508008 hasConcept C86803240 @default.
- W2033508008 hasConcept C98274493 @default.
- W2033508008 hasConceptScore W2033508008C108215921 @default.
- W2033508008 hasConceptScore W2033508008C109316439 @default.
- W2033508008 hasConceptScore W2033508008C126322002 @default.
- W2033508008 hasConceptScore W2033508008C181199279 @default.
- W2033508008 hasConceptScore W2033508008C185592680 @default.
- W2033508008 hasConceptScore W2033508008C202751555 @default.
- W2033508008 hasConceptScore W2033508008C2776985229 @default.
- W2033508008 hasConceptScore W2033508008C2778397455 @default.
- W2033508008 hasConceptScore W2033508008C2778461978 @default.
- W2033508008 hasConceptScore W2033508008C2780017796 @default.
- W2033508008 hasConceptScore W2033508008C2780352252 @default.
- W2033508008 hasConceptScore W2033508008C2781059491 @default.
- W2033508008 hasConceptScore W2033508008C2781184954 @default.
- W2033508008 hasConceptScore W2033508008C55493867 @default.
- W2033508008 hasConceptScore W2033508008C71315377 @default.
- W2033508008 hasConceptScore W2033508008C71924100 @default.
- W2033508008 hasConceptScore W2033508008C86803240 @default.
- W2033508008 hasConceptScore W2033508008C98274493 @default.
- W2033508008 hasIssue "8" @default.
- W2033508008 hasLocation W20335080081 @default.
- W2033508008 hasLocation W20335080082 @default.
- W2033508008 hasOpenAccess W2033508008 @default.
- W2033508008 hasPrimaryLocation W20335080081 @default.
- W2033508008 hasRelatedWork W1984221227 @default.
- W2033508008 hasRelatedWork W1996962055 @default.
- W2033508008 hasRelatedWork W2005045642 @default.
- W2033508008 hasRelatedWork W2033508008 @default.
- W2033508008 hasRelatedWork W2093944145 @default.
- W2033508008 hasRelatedWork W2115267373 @default.
- W2033508008 hasRelatedWork W2466752122 @default.
- W2033508008 hasRelatedWork W2474139326 @default.
- W2033508008 hasRelatedWork W2966514917 @default.
- W2033508008 hasRelatedWork W4249913969 @default.
- W2033508008 hasVolume "19" @default.
- W2033508008 isParatext "false" @default.
- W2033508008 isRetracted "false" @default.
- W2033508008 magId "2033508008" @default.
- W2033508008 workType "article" @default.