FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033524926> ?p ?o ?g. }

• W2033524926 endingPage "1132" @default.
• W2033524926 startingPage "1121" @default.
• W2033524926 abstract "The glucuronidation of a series of chalcones (2'-hydroxychalcone, 2',4'-dihydroxychalcone, 3,2'-dihydroxychalcone, 4,2'-dihydroxychalcone, and cardamonin) and their corresponding cyclized flavanones (7-hydroxyflavanone, 3'-hydroxyflavanone, 4'-hydroxyflavanone, and alpinetin) by eight human UDP-glucuronosyltransferase (UGT) 1A enzymes was evaluated. A postcolumn metal complexation LC-MS/MS strategy was used successfully to produce characteristic mass spectrometric product ions that were utilized in combination with elution order trends to identify chalcone and flavanone monoglucuronides unambiguously, thus allowing determination of the regioselectivities of the UGT1A isoforms. The presence of hydroxy groups on the A- or B-ring had a significant effect on the glucuronide product yield and the site where glucuronidation occurred. For example, for reaction with UGT1A9, formation of the 2'-O-glucuronide was increased for dihydroxychalcones with A-ring hydroxy substituents. In contrast, although UGT1A8 reacted with 3,2'-dihydroxychalcone and 4,2'-dihydroxychalcone to yield 2'-O-glucuronide products, the presence of a B-ring hydroxy group at the 4' position on cardamonin and 2',4'-dihydroxychalcone quenched the reaction at the OH-2' position. Moreover, the A-ring OH-4 group promoted glucuronidation at the 2' position for the reaction of 4,2'-dihydroxychalcone with UGT1A1 and 1A3. For UGT1A7, hydroxy group substituents on the chalcone A-ring also promoted cyclization and formation of the corresponding flavanone glucuronide." @default.
• W2033524926 created "2016-06-24" @default.
• W2033524926 creator A5052628663 @default.
• W2033524926 creator A5085008696 @default.
• W2033524926 date "2013-05-29" @default.
• W2033524926 modified "2023-09-27" @default.
• W2033524926 title "Regiospecificity of Human UDP-glucuronosyltransferase Isoforms in Chalcone and Flavanone Glucuronidation Determined by Metal Complexation and Tandem Mass Spectrometry" @default.
• W2033524926 cites W1967829206 @default.
• W2033524926 cites W1970026477 @default.
• W2033524926 cites W1976087803 @default.
• W2033524926 cites W1987989506 @default.
• W2033524926 cites W1991048885 @default.
• W2033524926 cites W1999339057 @default.
• W2033524926 cites W2000174139 @default.
• W2033524926 cites W2004170415 @default.
• W2033524926 cites W2017898027 @default.
• W2033524926 cites W2018467834 @default.
• W2033524926 cites W2018692611 @default.
• W2033524926 cites W2023436982 @default.
• W2033524926 cites W2031282096 @default.
• W2033524926 cites W2033996228 @default.
• W2033524926 cites W2038724963 @default.
• W2033524926 cites W2046428714 @default.
• W2033524926 cites W2048367496 @default.
• W2033524926 cites W2051238015 @default.
• W2033524926 cites W2051496574 @default.
• W2033524926 cites W2062726893 @default.
• W2033524926 cites W2074401069 @default.
• W2033524926 cites W2074854847 @default.
• W2033524926 cites W2077814668 @default.
• W2033524926 cites W2087242576 @default.
• W2033524926 cites W2087695482 @default.
• W2033524926 cites W2090371347 @default.
• W2033524926 cites W2090445022 @default.
• W2033524926 cites W2094733979 @default.
• W2033524926 cites W2094768851 @default.
• W2033524926 cites W2116549563 @default.
• W2033524926 cites W2125905720 @default.
• W2033524926 cites W2130028558 @default.
• W2033524926 cites W2136941249 @default.
• W2033524926 cites W2146629981 @default.
• W2033524926 cites W2150417617 @default.
• W2033524926 cites W2171232497 @default.
• W2033524926 cites W2324590696 @default.
• W2033524926 cites W2951864513 @default.
• W2033524926 cites W4236533258 @default.
• W2033524926 doi "https://doi.org/10.1021/np400195z" @default.
• W2033524926 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3710688" @default.
• W2033524926 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23713759" @default.
• W2033524926 hasPublicationYear "2013" @default.
• W2033524926 type Work @default.
• W2033524926 sameAs 2033524926 @default.
• W2033524926 citedByCount "9" @default.
• W2033524926 countsByYear W20335249262014 @default.
• W2033524926 countsByYear W20335249262015 @default.
• W2033524926 countsByYear W20335249262017 @default.
• W2033524926 countsByYear W20335249262019 @default.
• W2033524926 countsByYear W20335249262021 @default.
• W2033524926 countsByYear W20335249262023 @default.
• W2033524926 crossrefType "journal-article" @default.
• W2033524926 hasAuthorship W2033524926A5052628663 @default.
• W2033524926 hasAuthorship W2033524926A5085008696 @default.
• W2033524926 hasBestOaLocation W20335249262 @default.
• W2033524926 hasConcept C134121241 @default.
• W2033524926 hasConcept C162356407 @default.
• W2033524926 hasConcept C178790620 @default.
• W2033524926 hasConcept C181199279 @default.
• W2033524926 hasConcept C185592680 @default.
• W2033524926 hasConcept C191897082 @default.
• W2033524926 hasConcept C192562407 @default.
• W2033524926 hasConcept C194671627 @default.
• W2033524926 hasConcept C2776292868 @default.
• W2033524926 hasConcept C2777477808 @default.
• W2033524926 hasConcept C2777481717 @default.
• W2033524926 hasConcept C2778004101 @default.
• W2033524926 hasConcept C2779054382 @default.
• W2033524926 hasConcept C2779186261 @default.
• W2033524926 hasConcept C2779396346 @default.
• W2033524926 hasConcept C2779907587 @default.
• W2033524926 hasConcept C2780378348 @default.
• W2033524926 hasConcept C2780764945 @default.
• W2033524926 hasConcept C31827203 @default.
• W2033524926 hasConcept C43617362 @default.
• W2033524926 hasConcept C55493867 @default.
• W2033524926 hasConcept C71240020 @default.
• W2033524926 hasConcept C87644729 @default.
• W2033524926 hasConceptScore W2033524926C134121241 @default.
• W2033524926 hasConceptScore W2033524926C162356407 @default.
• W2033524926 hasConceptScore W2033524926C178790620 @default.
• W2033524926 hasConceptScore W2033524926C181199279 @default.
• W2033524926 hasConceptScore W2033524926C185592680 @default.
• W2033524926 hasConceptScore W2033524926C191897082 @default.
• W2033524926 hasConceptScore W2033524926C192562407 @default.
• W2033524926 hasConceptScore W2033524926C194671627 @default.
• W2033524926 hasConceptScore W2033524926C2776292868 @default.
• W2033524926 hasConceptScore W2033524926C2777477808 @default.
• W2033524926 hasConceptScore W2033524926C2777481717 @default.
• W2033524926 hasConceptScore W2033524926C2778004101 @default.

• next