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• W2033528367 abstract "We previously reported that conjugated linoleic acid (CLA), a naturally occurring fatty acid, inhibits the growth of ERalpha(+) MCF-7 and ERalpha(-) MDA-MB-231 human breast cancer cells by negative modulation of the ERK/MAPK pathway and apoptosis induction. Here we show that in these cell lines CLA also down-regulates the PI3K/Akt cascade. In MCF-7 cells CLA also triggers ERalpha/PP2A complex formation reducing the phosphorylation state and transcriptional activity of Eralpha whereas in MDA-MB-231 cells CLA does not induce PP2A activation. Moreover, CLA induces the expression of proteins involved in cell adhesion and inhibits cell migration and MMP-2 activity. These findings suggest that CLA may induce the down-regulation of ERalpha signalling and the reduction of cell invasion through the modulation of balancing between phosphatases and kinases." @default.
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• W2033528367 date "2010-01-01" @default.
• W2033528367 modified "2023-10-16" @default.
• W2033528367 title "CLA reduces breast cancer cell growth and invasion through ERα and PI3K/Akt pathways" @default.
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• W2033528367 doi "https://doi.org/10.1016/j.cbi.2009.09.022" @default.
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