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• W2033533650 endingPage "161" @default.
• W2033533650 startingPage "150" @default.
• W2033533650 abstract "A murine T cell clone, 24-2C, responds specifically to human IgG (HGG) in the context of I-Ab. B cells purified from mouse spleen cells were examined for their function as antigen-presenting cells (APC) in the response of 24-2C cells to HGG. B cells functioned as APC for IL-2 production but not for proliferation, whereas spleen cells or spleen-adherent cells functioned as APC for both IL-2 production and proliferation. LPS-activated B cells also failed to induce the proliferative response. The addition of the culture supernatant of 24-2C cells stimulated with HGG presented by irradiated spleen cells to the culture of 24-2C cells, irradiated B cells, and HGG induced the proliferative response of 24-2C cells, whereas IL-1, IL-3, and/or interferon-gamma did not reconstitute the proliferation. The expression of IL-2 receptors (IL-2R) on 24-2C cells was examined using a monoclonal anti-mouse IL-2R antibody AMT 13 or 7D4. 24-2C cells cultured with spleen cells as APC expressed IL-2R. Those cultured alone or with B cells as APC did not express IL-2R. Enlargement of 24-2C cells in response to HGG was also examined, and the relative cell size of those cultured with B cells or spleen cells as APC was larger than that of those cultured alone. These results demonstrate that B cells as APC induce IL-2 production and cell size enlargement in the response of 24-2C cloned T cells to HGG, but not IL-2R expression nor proliferation." @default.
• W2033533650 created "2016-06-24" @default.
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• W2033533650 date "1987-08-01" @default.
• W2033533650 modified "2023-10-18" @default.
• W2033533650 title "B cells as antigen-presenting cells: Antigen-specific IL-2 production by cloned T cells without expression of IL-2 receptors" @default.
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• W2033533650 doi "https://doi.org/10.1016/0008-8749(87)90200-0" @default.
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• W2033533650 hasPublicationYear "1987" @default.
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