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- W2033537892 abstract "Neonatal respiratory distress syndrome (RDS) affects approximately 1% of live births, and the probability of RDS continues to be a major determinant in the timing of delivery. This study was designed to investigate the optimal gestational age–specific cutoff value for the FLM S/A assay (Abbott Laboratories) for predicting RDS. Amniotic fluid FLM S/A data were collected prospectively over a 2-year period. Women were included in the study if they delivered within 72 h of FLM S/A estimation. RDS was defined as a persistent oxygen requirement for >24 hours in the presence of radiographic evidence of neonatal pulmonary hyaline membrane disease. A total of 415 mother-neonate pairs (28 RDS, 387 non-RDS) met criteria for analysis. Both gestational age and FLM S/A values were independent predictors of RDS. By modeling the odds of RDS using a logistic regression with gestational age and FLM S/A values as continuous variables, a probability of RDS of ≤15% can be achieved with a FLM S/A cutoff of ≥60 mg surfactant/g albumin at 28 weeks' gestation, ≥50 at 30 weeks, ≥40 at 33 weeks, ≥30 at 35 weeks, and ≥20 at 37 weeks. These data describe a means of stratifying the probability of neonatal RDS using both gestational age and FLM S/A value and may be a useful model for clinical decision making. We are currently prospectively verifying these findings in a separate population." @default.
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- W2033537892 date "2003-12-01" @default.
- W2033537892 modified "2023-09-24" @default.
- W2033537892 title "The probability of neonatal respiratory distress syndrome as a function of gestational age and FLM S/A II value" @default.
- W2033537892 doi "https://doi.org/10.1016/j.ajog.2003.10.376" @default.
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