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• W2033537986 startingPage "14704" @default.
• W2033537986 abstract "A cytotoxic T lymphocyte (CTL) clone generated in vitro from the peripheral blood of a healthy HLA-A2-positive individual against a synthetic p53 protein-derived wild-type peptide (L9V) was shown to kill squamous carcinoma cell lines derived from two head and neck carcinomas, which expressed mutant p53 genes, in a L9V/HLA-A2 specific and restricted fashion. Thus, the normal tolerance against endogenously processed p53 protein-derived self-epitopes can be broken by peptide-specific in vitro priming. p53 protein-derived wild-type peptides might thus represent tumor associated target molecules for immunotherapeutical approaches." @default.
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• W2033537986 date "1996-12-10" @default.
• W2033537986 modified "2023-10-16" @default.
• W2033537986 title "Spontaneous human squamous cell carcinomas are killed by a human cytotoxic T lymphocyte clone recognizing a wild-type p53-derived peptide" @default.
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• W2033537986 doi "https://doi.org/10.1073/pnas.93.25.14704" @default.
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