Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033549215> ?p ?o ?g. }
Showing items 1 to 92 of
92
with 100 items per page.
- W2033549215 endingPage "240" @default.
- W2033549215 startingPage "235" @default.
- W2033549215 abstract "The controlling mechanism for adrenal androgen production has not been elucidated. The presence of receptors for prolactin, human chorionic gonadotropin (hCG), insulin and insulin-like growth factor 1 (IGF-1) in the adrenal cortex raises the possibility of their involvement in the control of adrenal steroidogenesis. This study was undertaken to investigate the effects of prolactin, hCG, insulin and IGF-1 in the presence and absence of ACTH on cortisol and androgen production using isolated guinea-pig adrenal cells. hCG 10(-7) and 10(-6) M significantly increased cortisol (P < 0.05) production. hCG 10(-6) M significantly increased androstenedione (A4) (P < 0.05) production. In the presence of ACTH, 10(-12) M, hCG 10(-6) M significantly increased the cortisol (P < 0.01) and A4 (P < 0.01) responses. Although the mean cortisol and A4 response to ACTH 10(-9) M was reduced in the presence of hCG 10(-6) M, this was not statistically significant. Prolactin 10(-8) M increased cortisol (P < 0.01), A4, and dehydroepiandrosterone (P < 0.05) production. In the presence of ACTH 10(-12) M, prolactin 10(-8) M increased the cortisol and A4 (P < 0.05) responses. However, the maximally ACTH-stimulated cortisol and A4 responses were not significantly altered in the presence of prolactin 10(-8) M. Insulin 10(-11)-10(-8) M and IGF-1 10(-10)-10(-7) M resulted in no significant increase in cortisol, A4 or dehydroepiandrosterone production. This study suggests that prolactin and hCG could play a role in modulation of adrenal steroidogenesis, particularly when ACTH levels are low. However, there was no evidence that prolactin or hCG is the specific cortical androgen stimulating hormone." @default.
- W2033549215 created "2016-06-24" @default.
- W2033549215 creator A5053527243 @default.
- W2033549215 creator A5072191033 @default.
- W2033549215 creator A5076878027 @default.
- W2033549215 date "1994-02-01" @default.
- W2033549215 modified "2023-09-23" @default.
- W2033549215 title "The effect of prolactin, human chorionic gonadotropin, insulin and insulin-like growth factor 1 on adrenal steroidogenesis in isolated guinea-pig adrenal cells" @default.
- W2033549215 cites W1530509338 @default.
- W2033549215 cites W1964988005 @default.
- W2033549215 cites W1991024531 @default.
- W2033549215 cites W1995193394 @default.
- W2033549215 cites W2022815472 @default.
- W2033549215 cites W2024092789 @default.
- W2033549215 cites W2025017526 @default.
- W2033549215 cites W2027807182 @default.
- W2033549215 cites W2040592309 @default.
- W2033549215 cites W2055418571 @default.
- W2033549215 cites W2056938464 @default.
- W2033549215 cites W2065631591 @default.
- W2033549215 cites W2079932557 @default.
- W2033549215 cites W2083555322 @default.
- W2033549215 cites W2089183939 @default.
- W2033549215 cites W2094856597 @default.
- W2033549215 cites W2116973468 @default.
- W2033549215 cites W566136983 @default.
- W2033549215 doi "https://doi.org/10.1016/0960-0760(94)90150-3" @default.
- W2033549215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8142300" @default.
- W2033549215 hasPublicationYear "1994" @default.
- W2033549215 type Work @default.
- W2033549215 sameAs 2033549215 @default.
- W2033549215 citedByCount "30" @default.
- W2033549215 countsByYear W20335492152014 @default.
- W2033549215 countsByYear W20335492152015 @default.
- W2033549215 countsByYear W20335492152017 @default.
- W2033549215 countsByYear W20335492152018 @default.
- W2033549215 crossrefType "journal-article" @default.
- W2033549215 hasAuthorship W2033549215A5053527243 @default.
- W2033549215 hasAuthorship W2033549215A5072191033 @default.
- W2033549215 hasAuthorship W2033549215A5076878027 @default.
- W2033549215 hasConcept C126322002 @default.
- W2033549215 hasConcept C134018914 @default.
- W2033549215 hasConcept C185592680 @default.
- W2033549215 hasConcept C2775948956 @default.
- W2033549215 hasConcept C2776683971 @default.
- W2033549215 hasConcept C2776992908 @default.
- W2033549215 hasConcept C2777911890 @default.
- W2033549215 hasConcept C2777977426 @default.
- W2033549215 hasConcept C2778782382 @default.
- W2033549215 hasConcept C2779064019 @default.
- W2033549215 hasConcept C2779306644 @default.
- W2033549215 hasConcept C2780546910 @default.
- W2033549215 hasConcept C71315377 @default.
- W2033549215 hasConcept C71924100 @default.
- W2033549215 hasConcept C86803240 @default.
- W2033549215 hasConceptScore W2033549215C126322002 @default.
- W2033549215 hasConceptScore W2033549215C134018914 @default.
- W2033549215 hasConceptScore W2033549215C185592680 @default.
- W2033549215 hasConceptScore W2033549215C2775948956 @default.
- W2033549215 hasConceptScore W2033549215C2776683971 @default.
- W2033549215 hasConceptScore W2033549215C2776992908 @default.
- W2033549215 hasConceptScore W2033549215C2777911890 @default.
- W2033549215 hasConceptScore W2033549215C2777977426 @default.
- W2033549215 hasConceptScore W2033549215C2778782382 @default.
- W2033549215 hasConceptScore W2033549215C2779064019 @default.
- W2033549215 hasConceptScore W2033549215C2779306644 @default.
- W2033549215 hasConceptScore W2033549215C2780546910 @default.
- W2033549215 hasConceptScore W2033549215C71315377 @default.
- W2033549215 hasConceptScore W2033549215C71924100 @default.
- W2033549215 hasConceptScore W2033549215C86803240 @default.
- W2033549215 hasIssue "2-3" @default.
- W2033549215 hasLocation W20335492151 @default.
- W2033549215 hasLocation W20335492152 @default.
- W2033549215 hasOpenAccess W2033549215 @default.
- W2033549215 hasPrimaryLocation W20335492151 @default.
- W2033549215 hasRelatedWork W1557909868 @default.
- W2033549215 hasRelatedWork W1970873345 @default.
- W2033549215 hasRelatedWork W1973545014 @default.
- W2033549215 hasRelatedWork W1997576870 @default.
- W2033549215 hasRelatedWork W2031356831 @default.
- W2033549215 hasRelatedWork W2033549215 @default.
- W2033549215 hasRelatedWork W2122119142 @default.
- W2033549215 hasRelatedWork W2401508737 @default.
- W2033549215 hasRelatedWork W2148508279 @default.
- W2033549215 hasRelatedWork W2282724351 @default.
- W2033549215 hasVolume "48" @default.
- W2033549215 isParatext "false" @default.
- W2033549215 isRetracted "false" @default.
- W2033549215 magId "2033549215" @default.
- W2033549215 workType "article" @default.