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• W2033564801 abstract "A growing body of evidence suggests that tricyclic antidepressant agents (TCAs) interact with GTP binding proteins (G proteins). We have investigated if TCAs directly alter the function of the purified G o protein which is specifically expressed in neuronal tissue. Several TCAs markedly enhanced the GTPase activity of G o protein in a pertussis toxin-susceptible manner, whereas MAO-inhibitor and anxiolytic agent did not. This enhancing effect of TCAs on G o function may be due to an increase in the GDP-GTP exchange reaction occurring on G o . Thus, it is very likely that TCAs can modify various signal transduction by directly interacting with G proteins in brain cells." @default.
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• W2033564801 date "1992-05-01" @default.
• W2033564801 modified "2023-09-30" @default.
• W2033564801 title "Direct activation of purified Go-type GTP binding protein by tricyclic antidepressants" @default.
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• W2033564801 doi "https://doi.org/10.1016/0304-3940(92)90550-q" @default.
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