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• W2033565580 abstract "1. The recovery of contractile responses and appearance of new α-bungarotoxin-binding sites were studied in the baby chick biventer cervicis and the rat diaphragm muscles after saturating the existing acetylcholine (ACh) receptors (AChR) with α-bungarotoxin in vitro. 2. Washout of α-bungarotoxin restored gradually the response to exogenous ACh attaining about 30% recovery in 3 hr either in the chick muscle or in the denervated rat diaphragm. No recovery was obtained, however, for the response to nerve stimulation. 3. The recovery of ACh-response was abolished by decreasing the bath temperature to 9° C during the washout of the toxin whereas the recovery was not reduced in the presence of cycloheximide. 4. The half-life of [3H]acetyl α-bungarotoxin bound specifically on the existing AChRs, junctional and extrajunctional receptors combined, was 16 hr in the chick muscle. That on the extrajunctional AChR was estimated to be 8 hr. 5. New toxin-binding sites were found to be incorporated on the membrane of extrajunctional site rapidly after treatment with α-bungarotoxin in the chick and the denervated rat muscles along the muscle fibres but not in the innervated rat diaphragm. Treatment with (+)-tubocurarine, ACh or decamethonium did not cause an appreciable increase of the toxin-binding sites. 6. The appearance of new binding sites was progressive during 5 hr at a rate of 24 sites/μm2.hr in the chick muscle and 42 sites/μm2.hr in the rat diaphragm denervated for 7 days. The existing extrajunctional AChR were about 50/μm2 and 192/μm2, respectively. 7. ACh effectively antagonized the binding of α-bungarotoxin with the new sites whereas (+)-tubocurarine was less effective than its effect on the existing AChR. 8. The new toxin-binding sites appeared to have a reduced capacity to evoke ACh response. 9. The incorporation of new binding sites was reduced by lowering of the temperature, treatment with dinitrophenol, high K+, high Ca2+ and by the stimulation of either nerve or muscle. Cycloheximide, ACh, decrease of [Na+]o and increase of [Mg2+]o were without effect. 10. It is suggested that binding of the extrajunctional AChRs with α-bungarotoxin cause a change of membrane architecture and trigger the incorporation of cytoplasmic AChR-precursor or hidden AChR into the membrane." @default.
• W2033565580 created "2016-06-24" @default.
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• W2033565580 date "1977-06-01" @default.
• W2033565580 modified "2023-10-17" @default.
• W2033565580 title "Appearance of new acetylcholine receptors on the baby chick biventer cervicis and denervated rat diaphragm muscles after blockade with α-bungarotoxin" @default.
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• W2033565580 doi "https://doi.org/10.1113/jphysiol.1977.sp011865" @default.
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