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- W2033570598 abstract "RATIONALE: Microbial translocation from the gastrointestinal tract into the systemic circulation may result in HIV-1 induced immune activation. HIV-infected children and healthy donors (HD) were examined to evaluate soluble markers of microbial translocation (LPS and endoCAb), soluble markers of macrophage activation (sCD14 and TNFα), and soluble markers of T cell activation (sCD62L). METHODS: Soluble factors were measured within plasma using ELISA. Samples from ten HIV-infected subjects, before and after antiretroviral therapy, were compared to thirteen HD. Comparisons among groups were analyzed by Student t test and regression analysis by Pearson correlation. RESULTS: Compared to HD, HIV-infected subjects had higher plasma LPS levels (2.81 ± 2.12 EU versus 0.02 ± 0.06 EU, respectively, p < 0.05), but no difference in plasma EndoCab levels were observed (84.83 ± 120.94 MMu/ml versus 92.32 ± 99.95 MMu/ml, respectively). Successful antiretroviral therapy did not result in significant declines LPS levels (p = 0.57). Plasma sCD14 and TNFα were higher in the HIV-infected group compared to HD. sCD14 levels were 1.17 ± 0.79 μg/ml and 0.92 ± 0.20 μg/ml respectively, (p < 0.05) while TNFα levels were 0.0068 ± 0.013 μg/ml and < 0.0001 μg/ml, respectively (p < 0.05). sCD62L was higher in the infected subjects, 0.0012 μg/ml compared to 0.0007 μg/ml in HD (p < 0.05). CONCLUSIONS: As expected, higher LPS levels suggests microbial translocation that persists in spite of effective therapy. There is direct activation of macrophages, as measured by elevated sCD14 and TNFα as well as higher levels of sCD62L, a novel measure of immune activation." @default.
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- W2033570598 date "2009-02-01" @default.
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- W2033570598 title "Measurements of Plasma Lipopolysacharide (LPS), Endotoxin Core IgM Antibody (EndoCAb), Soluble CD14 (sCD14), TNFα, and Soluble CD62L (sCD62L) Levels to Assess Microbial Translocation and Immune Activation in HIV-Infected Children and Adolescents" @default.
- W2033570598 doi "https://doi.org/10.1016/j.jaci.2008.12.073" @default.
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