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• W2033573044 abstract "SUMMARY Lipopopeptidephosphoglycan (LPPG) is a complex macromolecule from the surface of Entamoeba histolytica trophozoites. We analysed the interaction between LPPG and human macrophages and dendritic cells (DCs) and found that LPPG is internalized by these cells and activates them. The internalization process involves intracellular traffic from the cell membrane to late endosomes, as shown by co‐localization of LPPG with late endosomes marked with FITC‐dextran and LAMP‐1. LPPG‐activated DCs have increased expression of co‐stimulatory molecules CD80, CD86 and CD40 and produce pro‐inflammatory cytokines TNF‐α, IL‐8 and IL‐12. Taken together, these results show that LPPG activates antigen‐presenting cells and reaches intracellular compartments that are involved in antigen presentation." @default.
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• W2033573044 date "2007-08-23" @default.
• W2033573044 modified "2023-10-18" @default.
• W2033573044 title "Lipopopeptidephosphoglycan from Entamoeba histolytica activates human macrophages and dendritic cells and reaches their late endosomes" @default.
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• W2033573044 doi "https://doi.org/10.1111/j.1365-3024.2007.00963.x" @default.
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