Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033573378> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W2033573378 endingPage "207" @default.
- W2033573378 startingPage "196" @default.
- W2033573378 abstract "Two species of DHFR were identified in wild-type L1210 murine leukemia cells by analysis of the kinetics of the binding of MTX and dissociation of the MTX-enzyme complex at pH 5.0 and pH 7.2. The two forms of DHFR were also distinguished by immunoinhibition of the binding of MTX and the catalytic reduction of FH2 to FH4 using an antiserum raised to the purified high affinity form of DHFR. The Ka for the binding of MTX by the low affinity form of the enzyme is 4.5 x 10(7) M-1, substantially lower than the reported Ka for the binding of this drug by the high affinity enzyme. The low affinity form of the enzyme catalyzed the reduction of FH2 to FH4 at a rate slower than the high affinity form of DHFR." @default.
- W2033573378 created "2016-06-24" @default.
- W2033573378 creator A5053913561 @default.
- W2033573378 creator A5056019879 @default.
- W2033573378 creator A5066218270 @default.
- W2033573378 date "1991-10-01" @default.
- W2033573378 modified "2023-10-14" @default.
- W2033573378 title "Evidence for kinetic and immunologic heterogeneity of dihydrofolate reductase in L1210 leukemia cells" @default.
- W2033573378 cites W140209867 @default.
- W2033573378 cites W1509635893 @default.
- W2033573378 cites W1571490147 @default.
- W2033573378 cites W1983649348 @default.
- W2033573378 cites W1987402314 @default.
- W2033573378 cites W2001298057 @default.
- W2033573378 cites W2014629596 @default.
- W2033573378 cites W2014949715 @default.
- W2033573378 cites W2017350383 @default.
- W2033573378 cites W2038292406 @default.
- W2033573378 cites W2041716311 @default.
- W2033573378 cites W2051618424 @default.
- W2033573378 cites W2061024576 @default.
- W2033573378 cites W2067870267 @default.
- W2033573378 cites W2084397127 @default.
- W2033573378 cites W2093115669 @default.
- W2033573378 cites W2222781894 @default.
- W2033573378 cites W2604049257 @default.
- W2033573378 cites W43836846 @default.
- W2033573378 cites W56314674 @default.
- W2033573378 doi "https://doi.org/10.1016/0885-4505(91)90067-u" @default.
- W2033573378 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/1782010" @default.
- W2033573378 hasPublicationYear "1991" @default.
- W2033573378 type Work @default.
- W2033573378 sameAs 2033573378 @default.
- W2033573378 citedByCount "1" @default.
- W2033573378 crossrefType "journal-article" @default.
- W2033573378 hasAuthorship W2033573378A5053913561 @default.
- W2033573378 hasAuthorship W2033573378A5056019879 @default.
- W2033573378 hasAuthorship W2033573378A5066218270 @default.
- W2033573378 hasConcept C109316439 @default.
- W2033573378 hasConcept C121332964 @default.
- W2033573378 hasConcept C147483822 @default.
- W2033573378 hasConcept C148898269 @default.
- W2033573378 hasConcept C153911025 @default.
- W2033573378 hasConcept C179247698 @default.
- W2033573378 hasConcept C181199279 @default.
- W2033573378 hasConcept C185592680 @default.
- W2033573378 hasConcept C202751555 @default.
- W2033573378 hasConcept C203014093 @default.
- W2033573378 hasConcept C2776980637 @default.
- W2033573378 hasConcept C2778461978 @default.
- W2033573378 hasConcept C2780017796 @default.
- W2033573378 hasConcept C2781320022 @default.
- W2033573378 hasConcept C41183919 @default.
- W2033573378 hasConcept C55493867 @default.
- W2033573378 hasConcept C56856141 @default.
- W2033573378 hasConcept C62520636 @default.
- W2033573378 hasConcept C86803240 @default.
- W2033573378 hasConcept C91523082 @default.
- W2033573378 hasConceptScore W2033573378C109316439 @default.
- W2033573378 hasConceptScore W2033573378C121332964 @default.
- W2033573378 hasConceptScore W2033573378C147483822 @default.
- W2033573378 hasConceptScore W2033573378C148898269 @default.
- W2033573378 hasConceptScore W2033573378C153911025 @default.
- W2033573378 hasConceptScore W2033573378C179247698 @default.
- W2033573378 hasConceptScore W2033573378C181199279 @default.
- W2033573378 hasConceptScore W2033573378C185592680 @default.
- W2033573378 hasConceptScore W2033573378C202751555 @default.
- W2033573378 hasConceptScore W2033573378C203014093 @default.
- W2033573378 hasConceptScore W2033573378C2776980637 @default.
- W2033573378 hasConceptScore W2033573378C2778461978 @default.
- W2033573378 hasConceptScore W2033573378C2780017796 @default.
- W2033573378 hasConceptScore W2033573378C2781320022 @default.
- W2033573378 hasConceptScore W2033573378C41183919 @default.
- W2033573378 hasConceptScore W2033573378C55493867 @default.
- W2033573378 hasConceptScore W2033573378C56856141 @default.
- W2033573378 hasConceptScore W2033573378C62520636 @default.
- W2033573378 hasConceptScore W2033573378C86803240 @default.
- W2033573378 hasConceptScore W2033573378C91523082 @default.
- W2033573378 hasIssue "2" @default.
- W2033573378 hasLocation W20335733781 @default.
- W2033573378 hasLocation W20335733782 @default.
- W2033573378 hasOpenAccess W2033573378 @default.
- W2033573378 hasPrimaryLocation W20335733781 @default.
- W2033573378 hasRelatedWork W2027286975 @default.
- W2033573378 hasRelatedWork W2033573378 @default.
- W2033573378 hasRelatedWork W2041716311 @default.
- W2033573378 hasRelatedWork W2043234874 @default.
- W2033573378 hasRelatedWork W2169074213 @default.
- W2033573378 hasRelatedWork W2373329635 @default.
- W2033573378 hasRelatedWork W2398687087 @default.
- W2033573378 hasRelatedWork W2418977795 @default.
- W2033573378 hasRelatedWork W3156658336 @default.
- W2033573378 hasRelatedWork W4246417352 @default.
- W2033573378 hasVolume "46" @default.
- W2033573378 isParatext "false" @default.
- W2033573378 isRetracted "false" @default.
- W2033573378 magId "2033573378" @default.
- W2033573378 workType "article" @default.