FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033577436> ?p ?o ?g. }

• W2033577436 endingPage "193" @default.
• W2033577436 startingPage "177" @default.
• W2033577436 abstract "PSIP1 (PC4 and SFRS1 interacting protein 1) encodes two splice variants: lens epithelium-derived growth factor or p75 (LEDGF/p75) and p52. PSIP1 gene products were shown to be involved in transcriptional regulation, affecting a plethora of cellular processes, including cell proliferation, cell survival, and stress response. Furthermore, LEDGF/p75 has implications for various diseases and infections, including autoimmunity, leukemia, embryo development, psoriasis, and human immunodeficiency virus integration. Here, we reported the first characterization of the PSIP1 promoter. Using 5′ RNA ligase-mediated rapid amplification of cDNA ends, we identified novel transcription start sites in different cell types. Using a luciferase reporter system, we identified regulatory elements controlling the expression of LEDGF/p75 and p52. These include (i) minimal promoters (− 112/+ 59 and + 609/+ 781) that drive the basal expression of LEDGF/p75 and of the shorter splice variant p52, respectively; (ii) a sequence (+ 319/+ 397) that may control the ratio of LEDGF/p75 expression to p52 expression; and (iii) a strong enhancer (− 320/− 207) implicated in the modulation of LEDGF/p75 transcriptional activity. Computational, biochemical, and genetic approaches enabled us to identify the transcription factor Sp1 as a key modulator of the PSIP1 promoter, controlling LEDGF/p75 transcription through two binding sites at − 72/− 64 and − 46/− 36. Overall, our results provide initial data concerning LEDGF/p75 promoter regulation, giving new insights to further understand its biological function and opening the door for new therapeutic strategies in which LEDGF/p75 is involved." @default.
• W2033577436 created "2016-06-24" @default.
• W2033577436 creator A5003279436 @default.
• W2033577436 creator A5012546332 @default.
• W2033577436 creator A5016071972 @default.
• W2033577436 creator A5041595842 @default.
• W2033577436 creator A5072836934 @default.
• W2033577436 date "2011-11-01" @default.
• W2033577436 modified "2023-10-13" @default.
• W2033577436 title "LEDGF/p75 TATA-Less Promoter Is Driven by the Transcription Factor Sp1" @default.
• W2033577436 cites W1544629041 @default.
• W2033577436 cites W1613840355 @default.
• W2033577436 cites W181090678 @default.
• W2033577436 cites W1896222878 @default.
• W2033577436 cites W1964170347 @default.
• W2033577436 cites W1964423038 @default.
• W2033577436 cites W1967301672 @default.
• W2033577436 cites W1976600302 @default.
• W2033577436 cites W1982234546 @default.
• W2033577436 cites W1991259976 @default.
• W2033577436 cites W1991352945 @default.
• W2033577436 cites W1992901862 @default.
• W2033577436 cites W1996757479 @default.
• W2033577436 cites W2002073949 @default.
• W2033577436 cites W2008698762 @default.
• W2033577436 cites W2022269865 @default.
• W2033577436 cites W2023461806 @default.
• W2033577436 cites W2030949296 @default.
• W2033577436 cites W2033958009 @default.
• W2033577436 cites W2057692691 @default.
• W2033577436 cites W2070412642 @default.
• W2033577436 cites W2074469807 @default.
• W2033577436 cites W2075085893 @default.
• W2033577436 cites W2082485360 @default.
• W2033577436 cites W2084324047 @default.
• W2033577436 cites W2085489729 @default.
• W2033577436 cites W2086802063 @default.
• W2033577436 cites W2087087888 @default.
• W2033577436 cites W2090073257 @default.
• W2033577436 cites W2094799740 @default.
• W2033577436 cites W2103720603 @default.
• W2033577436 cites W2107736526 @default.
• W2033577436 cites W2118906222 @default.
• W2033577436 cites W2118921541 @default.
• W2033577436 cites W2127800890 @default.
• W2033577436 cites W2131649633 @default.
• W2033577436 cites W2136996190 @default.
• W2033577436 cites W2140048866 @default.
• W2033577436 cites W2140812363 @default.
• W2033577436 cites W2155139733 @default.
• W2033577436 cites W2160783048 @default.
• W2033577436 cites W2164670308 @default.
• W2033577436 cites W2166026694 @default.
• W2033577436 cites W2167142486 @default.
• W2033577436 cites W2329688524 @default.
• W2033577436 doi "https://doi.org/10.1016/j.jmb.2011.10.010" @default.
• W2033577436 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22019592" @default.
• W2033577436 hasPublicationYear "2011" @default.
• W2033577436 type Work @default.
• W2033577436 sameAs 2033577436 @default.
• W2033577436 citedByCount "12" @default.
• W2033577436 countsByYear W20335774362012 @default.
• W2033577436 countsByYear W20335774362013 @default.
• W2033577436 countsByYear W20335774362014 @default.
• W2033577436 countsByYear W20335774362015 @default.
• W2033577436 countsByYear W20335774362016 @default.
• W2033577436 countsByYear W20335774362017 @default.
• W2033577436 countsByYear W20335774362018 @default.
• W2033577436 countsByYear W20335774362020 @default.
• W2033577436 countsByYear W20335774362021 @default.
• W2033577436 crossrefType "journal-article" @default.
• W2033577436 hasAuthorship W2033577436A5003279436 @default.
• W2033577436 hasAuthorship W2033577436A5012546332 @default.
• W2033577436 hasAuthorship W2033577436A5016071972 @default.
• W2033577436 hasAuthorship W2033577436A5041595842 @default.
• W2033577436 hasAuthorship W2033577436A5072836934 @default.
• W2033577436 hasBestOaLocation W20335774362 @default.
• W2033577436 hasConcept C101762097 @default.
• W2033577436 hasConcept C104317684 @default.
• W2033577436 hasConcept C111936080 @default.
• W2033577436 hasConcept C150194340 @default.
• W2033577436 hasConcept C153911025 @default.
• W2033577436 hasConcept C54355233 @default.
• W2033577436 hasConcept C65888428 @default.
• W2033577436 hasConcept C86339819 @default.
• W2033577436 hasConcept C86803240 @default.
• W2033577436 hasConcept C95444343 @default.
• W2033577436 hasConceptScore W2033577436C101762097 @default.
• W2033577436 hasConceptScore W2033577436C104317684 @default.
• W2033577436 hasConceptScore W2033577436C111936080 @default.
• W2033577436 hasConceptScore W2033577436C150194340 @default.
• W2033577436 hasConceptScore W2033577436C153911025 @default.
• W2033577436 hasConceptScore W2033577436C54355233 @default.
• W2033577436 hasConceptScore W2033577436C65888428 @default.
• W2033577436 hasConceptScore W2033577436C86339819 @default.
• W2033577436 hasConceptScore W2033577436C86803240 @default.
• W2033577436 hasConceptScore W2033577436C95444343 @default.
• W2033577436 hasIssue "2" @default.

• next