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- W2033586999 abstract "The effect of L-threo-3,4-dihydroxyphenylserine (L-DOPS) on norepinephrine (NE) levels in plasma and CSF was examined in urethane-anesthetized rats. Intravenous injection of L-DOPS (0.5, 1, and 10 mg/100 g body wt) raised plasma NE levels in a dose-related manner whereas CSF NE levels were significantly increased only by the largest dose of L-DOPS. Intracerebroventricular injection of L-DOPS (50 and 250 micrograms/rat) dose-relatedly raised CSF NE levels whereas plasma NE levels were slightly increased by a larger dose of L-DOPS. These findings may indicate that L-DOPS stimulates central noradrenergic mechanisms in the rat although a large dose of L-DOPS is required for peripheral administration." @default.
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- W2033586999 date "1987-02-01" @default.
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- W2033586999 title "Effect of L-Threo-3,4-dihydroxyphenylserine (L-DOPS) on Catecholamine Levels in Plasma and Cerebrospinal Fluid (CSF) in Anesthetized Rats" @default.
- W2033586999 doi "https://doi.org/10.3181/00379727-184-42467" @default.
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