FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033591730> ?p ?o ?g. }

• W2033591730 endingPage "1092" @default.
• W2033591730 startingPage "1084" @default.
• W2033591730 abstract "Targeting early infection in mucosal sites is one of the primary goals for mucosal vaccines so as to prevent pathogen mucosal transmission and infection. The TLR5 agonist flagellin was deemed to be a mucosal adjuvant candidate for clinical usage. However, the high antigenicity of flagellin and the possible inflammatory injury induced by flagellin might restrict its clinical usage. Here HIV-1 p24 protein was selected as an antigen model and we replaced the main antigenicity region domains D2 and D3 of non-pathogenic E.coli-derived flagellin (KF). The derived soluble protein KFD-p24 3D was then compared with KF-p24, which fused p24 directly to the C-terminal of KF. In vitro and ex vivo experiments showed that KFD-p24 3D has lower TLR5 agonist efficacy and less immunocyte-activating efficacy. Interestingly, the production of KF- specific antibody was highly reduced, and KFD-p24 3D induced IgA-biased antibody responses in mucosal sites. Moreover, KFD-p24 3D induced far fewer systemic inflammatory responses and abrogated detectable inflammatory side effects on mice, even at the high dose. The properties of enhanced IgA generation and attenuated inflammatory responses broaden the safe-dose range of KFD-p24 3D flagellin, creating a potentially promising mucosal adjuvant." @default.
• W2033591730 created "2016-06-24" @default.
• W2033591730 creator A5005085857 @default.
• W2033591730 creator A5007785689 @default.
• W2033591730 creator A5023307885 @default.
• W2033591730 creator A5026655079 @default.
• W2033591730 creator A5033648442 @default.
• W2033591730 creator A5034567906 @default.
• W2033591730 creator A5039345848 @default.
• W2033591730 creator A5045153029 @default.
• W2033591730 creator A5056375074 @default.
• W2033591730 creator A5057540672 @default.
• W2033591730 creator A5058920358 @default.
• W2033591730 creator A5067708880 @default.
• W2033591730 creator A5084310743 @default.
• W2033591730 date "2013-05-14" @default.
• W2033591730 modified "2023-09-25" @default.
• W2033591730 title "Antigen replacement of domains D2 and D3 in flagellin promotes mucosal IgA production and attenuates flagellin-induced inflammatory response after intranasal immunization" @default.
• W2033591730 cites W1514734569 @default.
• W2033591730 cites W1517080148 @default.
• W2033591730 cites W1540453462 @default.
• W2033591730 cites W1621593382 @default.
• W2033591730 cites W1664413187 @default.
• W2033591730 cites W1976927528 @default.
• W2033591730 cites W1991083095 @default.
• W2033591730 cites W1991227056 @default.
• W2033591730 cites W1992054873 @default.
• W2033591730 cites W2005464097 @default.
• W2033591730 cites W2006990207 @default.
• W2033591730 cites W2007041007 @default.
• W2033591730 cites W2007265326 @default.
• W2033591730 cites W2014047240 @default.
• W2033591730 cites W2015245677 @default.
• W2033591730 cites W2017863388 @default.
• W2033591730 cites W2025859766 @default.
• W2033591730 cites W2027606763 @default.
• W2033591730 cites W2027993940 @default.
• W2033591730 cites W2034722126 @default.
• W2033591730 cites W2036453977 @default.
• W2033591730 cites W2038633253 @default.
• W2033591730 cites W2044460909 @default.
• W2033591730 cites W2044672904 @default.
• W2033591730 cites W2046101261 @default.
• W2033591730 cites W2050285009 @default.
• W2033591730 cites W2051851091 @default.
• W2033591730 cites W2052003687 @default.
• W2033591730 cites W2052874989 @default.
• W2033591730 cites W2053397495 @default.
• W2033591730 cites W2076613161 @default.
• W2033591730 cites W2077014200 @default.
• W2033591730 cites W2078489697 @default.
• W2033591730 cites W2080512334 @default.
• W2033591730 cites W2099888678 @default.
• W2033591730 cites W2111593523 @default.
• W2033591730 cites W2120482236 @default.
• W2033591730 cites W2121531174 @default.
• W2033591730 cites W2126953691 @default.
• W2033591730 cites W2127938365 @default.
• W2033591730 cites W2129486022 @default.
• W2033591730 cites W2133373151 @default.
• W2033591730 cites W2137003603 @default.
• W2033591730 cites W2138367490 @default.
• W2033591730 cites W2141449280 @default.
• W2033591730 cites W2145380311 @default.
• W2033591730 cites W2149104733 @default.
• W2033591730 cites W2154320306 @default.
• W2033591730 cites W2158415381 @default.
• W2033591730 cites W2159923852 @default.
• W2033591730 cites W2164240196 @default.
• W2033591730 doi "https://doi.org/10.4161/hv.23809" @default.
• W2033591730 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3899144" @default.
• W2033591730 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23377752" @default.
• W2033591730 hasPublicationYear "2013" @default.
• W2033591730 type Work @default.
• W2033591730 sameAs 2033591730 @default.
• W2033591730 citedByCount "32" @default.
• W2033591730 countsByYear W20335917302013 @default.
• W2033591730 countsByYear W20335917302014 @default.
• W2033591730 countsByYear W20335917302015 @default.
• W2033591730 countsByYear W20335917302016 @default.
• W2033591730 countsByYear W20335917302017 @default.
• W2033591730 countsByYear W20335917302018 @default.
• W2033591730 countsByYear W20335917302019 @default.
• W2033591730 countsByYear W20335917302020 @default.
• W2033591730 countsByYear W20335917302021 @default.
• W2033591730 countsByYear W20335917302022 @default.
• W2033591730 countsByYear W20335917302023 @default.
• W2033591730 crossrefType "journal-article" @default.
• W2033591730 hasAuthorship W2033591730A5005085857 @default.
• W2033591730 hasAuthorship W2033591730A5007785689 @default.
• W2033591730 hasAuthorship W2033591730A5023307885 @default.
• W2033591730 hasAuthorship W2033591730A5026655079 @default.
• W2033591730 hasAuthorship W2033591730A5033648442 @default.
• W2033591730 hasAuthorship W2033591730A5034567906 @default.
• W2033591730 hasAuthorship W2033591730A5039345848 @default.
• W2033591730 hasAuthorship W2033591730A5045153029 @default.
• W2033591730 hasAuthorship W2033591730A5056375074 @default.
• W2033591730 hasAuthorship W2033591730A5057540672 @default.

• next