FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033611111> ?p ?o ?g. }

• W2033611111 endingPage "e67037" @default.
• W2033611111 startingPage "e67037" @default.
• W2033611111 abstract "Background Schistosomiasis japonica remains a significant public health problem in China and Southeast Asian countries. The most typical and serious outcome of the chronic oriental schistosomiasis is the progressive granuloma and fibrosis in the host liver, which has been a major medical challenge. However, the molecular mechanism underling the hepatic pathogenesis is still not clear. Methodology and Principal Findings Using microarrays, we quantified the temporal gene expression profiles in the liver of Schistosoma japonicum-infected BALB/c mice at 15, 30, and 45 day post infection (dpi) with that from uninfected mice as controls. Gene expression alternation associated with liver damage was observed in the initial phase of infection (dpi 15), which became more magnificent with the onset of egg-laying. Up-regulated genes were dominantly associated with inflammatory infiltration, whereas down-regulated genes primarily led to the hepatic functional disorders. Simultaneously, microRNA profiles from the same samples were decoded by Solexa sequencing. More than 130 miRNAs were differentially expressed in murine liver during S. japonicum infection. MiRNAs significantly dysregulated in the mid-phase of infection (dpi 30), such as mmu-miR-146b and mmu-miR-155, may relate to the regulation of hepatic inflammatory responses, whereas miRNAs exhibiting a peak expression in the late phase of infection (dpi 45), such as mmu-miR-223, mmu-miR-146a/b, mmu-miR-155, mmu-miR-34c, mmu-miR-199, and mmu-miR-134, may represent a molecular signature of the development of schistosomal hepatopathy. Further, a dynamic miRNA-gene co-expression network in the progression of infection was constructed. Conclusions and Significance This study presents a global view of dynamic expression of both mRNA and miRNA transcripts in murine liver during S. japonicum infection, and highlights that miRNAs may play a variety of regulatory roles in balancing the immune responses during the development of hepatic pathology. The data provide robust information for further researches on the pathogenesis and molecular events of hepatopathy induced by schistosome eggs." @default.
• W2033611111 created "2016-06-24" @default.
• W2033611111 creator A5000167242 @default.
• W2033611111 creator A5002076661 @default.
• W2033611111 creator A5003930369 @default.
• W2033611111 creator A5015470689 @default.
• W2033611111 creator A5073789459 @default.
• W2033611111 creator A5085331622 @default.
• W2033611111 date "2013-06-25" @default.
• W2033611111 modified "2023-10-18" @default.
• W2033611111 title "MicroRNA-Gene Expression Network in Murine Liver during Schistosoma japonicum Infection" @default.
• W2033611111 cites W1489063373 @default.
• W2033611111 cites W1496588321 @default.
• W2033611111 cites W1666961740 @default.
• W2033611111 cites W1932560099 @default.
• W2033611111 cites W1966789801 @default.
• W2033611111 cites W1969561666 @default.
• W2033611111 cites W1973692821 @default.
• W2033611111 cites W1983251505 @default.
• W2033611111 cites W1984469930 @default.
• W2033611111 cites W1987851658 @default.
• W2033611111 cites W1987935765 @default.
• W2033611111 cites W1992710380 @default.
• W2033611111 cites W1996396767 @default.
• W2033611111 cites W1996441871 @default.
• W2033611111 cites W2000750221 @default.
• W2033611111 cites W2001927173 @default.
• W2033611111 cites W2013179998 @default.
• W2033611111 cites W2014869583 @default.
• W2033611111 cites W2014974499 @default.
• W2033611111 cites W2015149302 @default.
• W2033611111 cites W2023275569 @default.
• W2033611111 cites W2024177760 @default.
• W2033611111 cites W2025418819 @default.
• W2033611111 cites W2028008068 @default.
• W2033611111 cites W2028912652 @default.
• W2033611111 cites W2029298887 @default.
• W2033611111 cites W2029485495 @default.
• W2033611111 cites W2029769204 @default.
• W2033611111 cites W2036169252 @default.
• W2033611111 cites W2041885763 @default.
• W2033611111 cites W2049772720 @default.
• W2033611111 cites W2053923770 @default.
• W2033611111 cites W2058766645 @default.
• W2033611111 cites W2058945550 @default.
• W2033611111 cites W2060045602 @default.
• W2033611111 cites W2062997740 @default.
• W2033611111 cites W2065543285 @default.
• W2033611111 cites W2070571588 @default.
• W2033611111 cites W2075860675 @default.
• W2033611111 cites W2081076969 @default.
• W2033611111 cites W2083578123 @default.
• W2033611111 cites W2088085204 @default.
• W2033611111 cites W2091096046 @default.
• W2033611111 cites W2093804567 @default.
• W2033611111 cites W2112192177 @default.
• W2033611111 cites W2112517453 @default.
• W2033611111 cites W2116815663 @default.
• W2033611111 cites W2118459716 @default.
• W2033611111 cites W2121599969 @default.
• W2033611111 cites W2133220812 @default.
• W2033611111 cites W2139326439 @default.
• W2033611111 cites W2139760555 @default.
• W2033611111 cites W2147638953 @default.
• W2033611111 cites W2148508334 @default.
• W2033611111 cites W2153195747 @default.
• W2033611111 cites W2162674813 @default.
• W2033611111 cites W2163480486 @default.
• W2033611111 cites W2164262821 @default.
• W2033611111 cites W2170533910 @default.
• W2033611111 cites W2171507390 @default.
• W2033611111 cites W4231824804 @default.
• W2033611111 doi "https://doi.org/10.1371/journal.pone.0067037" @default.
• W2033611111 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3692539" @default.
• W2033611111 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/23825609" @default.
• W2033611111 hasPublicationYear "2013" @default.
• W2033611111 type Work @default.
• W2033611111 sameAs 2033611111 @default.
• W2033611111 citedByCount "41" @default.
• W2033611111 countsByYear W20336111112014 @default.
• W2033611111 countsByYear W20336111112015 @default.
• W2033611111 countsByYear W20336111112016 @default.
• W2033611111 countsByYear W20336111112017 @default.
• W2033611111 countsByYear W20336111112018 @default.
• W2033611111 countsByYear W20336111112019 @default.
• W2033611111 countsByYear W20336111112020 @default.
• W2033611111 countsByYear W20336111112021 @default.
• W2033611111 countsByYear W20336111112022 @default.
• W2033611111 countsByYear W20336111112023 @default.
• W2033611111 crossrefType "journal-article" @default.
• W2033611111 hasAuthorship W2033611111A5000167242 @default.
• W2033611111 hasAuthorship W2033611111A5002076661 @default.
• W2033611111 hasAuthorship W2033611111A5003930369 @default.
• W2033611111 hasAuthorship W2033611111A5015470689 @default.
• W2033611111 hasAuthorship W2033611111A5073789459 @default.
• W2033611111 hasAuthorship W2033611111A5085331622 @default.
• W2033611111 hasBestOaLocation W20336111111 @default.
• W2033611111 hasConcept C104317684 @default.

• next