Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033619005> ?p ?o ?g. }
- W2033619005 endingPage "3469" @default.
- W2033619005 startingPage "3458" @default.
- W2033619005 abstract "The treatment options for cancer patients include surgery, chemotherapeutics, radiation therapy, antibody therapy and various combinations of these therapies. The challenge with each therapy is finding the balance between maximizing the anti-tumor efficacy while minimizing the dose limiting toxicities. Antibodies, unlike small molecule chemotherapeutics, selectively bind to cell surface tumor antigens and can be used to deliver radionucleotides or small molecule chemotherapeutic drugs directly to the tumor. Advances in antibody engineering, linker chemistry and the identification of potent cytotoxic drugs led to the recent approval of two antibody drug conjugates to treat breast cancer and lymphoma patients. We will discuss how the observations from the clinical development of antibody drug conjugates can guide the preclinical development of the next generation of antibody drug conjugates." @default.
- W2033619005 created "2016-06-24" @default.
- W2033619005 creator A5059160317 @default.
- W2033619005 creator A5072189533 @default.
- W2033619005 date "2014-10-23" @default.
- W2033619005 modified "2023-09-27" @default.
- W2033619005 title "Using the Lessons Learned From the Clinic to Improve the Preclinical Development of Antibody Drug Conjugates" @default.
- W2033619005 cites W147746226 @default.
- W2033619005 cites W1495668897 @default.
- W2033619005 cites W183128447 @default.
- W2033619005 cites W1832002274 @default.
- W2033619005 cites W1966840924 @default.
- W2033619005 cites W1977241343 @default.
- W2033619005 cites W1977436845 @default.
- W2033619005 cites W1979573410 @default.
- W2033619005 cites W1984250533 @default.
- W2033619005 cites W1984342356 @default.
- W2033619005 cites W1986328213 @default.
- W2033619005 cites W1987301058 @default.
- W2033619005 cites W1989874094 @default.
- W2033619005 cites W1990918503 @default.
- W2033619005 cites W1999212901 @default.
- W2033619005 cites W2004783782 @default.
- W2033619005 cites W2020946741 @default.
- W2033619005 cites W2026373761 @default.
- W2033619005 cites W2030611514 @default.
- W2033619005 cites W2036479586 @default.
- W2033619005 cites W2036562940 @default.
- W2033619005 cites W2037248548 @default.
- W2033619005 cites W2042701817 @default.
- W2033619005 cites W2042712910 @default.
- W2033619005 cites W2044472571 @default.
- W2033619005 cites W2050305366 @default.
- W2033619005 cites W2055242684 @default.
- W2033619005 cites W2055642315 @default.
- W2033619005 cites W2055713782 @default.
- W2033619005 cites W2058332629 @default.
- W2033619005 cites W2066477716 @default.
- W2033619005 cites W2071163127 @default.
- W2033619005 cites W2073176225 @default.
- W2033619005 cites W2077470692 @default.
- W2033619005 cites W2082973537 @default.
- W2033619005 cites W2083709832 @default.
- W2033619005 cites W2083802683 @default.
- W2033619005 cites W2087267013 @default.
- W2033619005 cites W2088391278 @default.
- W2033619005 cites W2088609615 @default.
- W2033619005 cites W2090057677 @default.
- W2033619005 cites W2092456583 @default.
- W2033619005 cites W2093580676 @default.
- W2033619005 cites W2102297721 @default.
- W2033619005 cites W2103606399 @default.
- W2033619005 cites W2104182248 @default.
- W2033619005 cites W2104527259 @default.
- W2033619005 cites W2104998312 @default.
- W2033619005 cites W2113426218 @default.
- W2033619005 cites W2115100262 @default.
- W2033619005 cites W2116150122 @default.
- W2033619005 cites W2121080375 @default.
- W2033619005 cites W2124467421 @default.
- W2033619005 cites W2124514746 @default.
- W2033619005 cites W2134433047 @default.
- W2033619005 cites W2134758761 @default.
- W2033619005 cites W2137231887 @default.
- W2033619005 cites W2138352319 @default.
- W2033619005 cites W2138654358 @default.
- W2033619005 cites W2141607135 @default.
- W2033619005 cites W2143892831 @default.
- W2033619005 cites W2146457529 @default.
- W2033619005 cites W2148644851 @default.
- W2033619005 cites W2150648608 @default.
- W2033619005 cites W2159967578 @default.
- W2033619005 cites W2167463450 @default.
- W2033619005 cites W2169302611 @default.
- W2033619005 cites W2170426247 @default.
- W2033619005 cites W2171368669 @default.
- W2033619005 cites W2286803867 @default.
- W2033619005 cites W2290094801 @default.
- W2033619005 cites W4230483407 @default.
- W2033619005 cites W4231780986 @default.
- W2033619005 cites W4252911605 @default.
- W2033619005 cites W47013412 @default.
- W2033619005 cites W81419320 @default.
- W2033619005 doi "https://doi.org/10.1007/s11095-014-1536-7" @default.
- W2033619005 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4596896" @default.
- W2033619005 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/25339341" @default.
- W2033619005 hasPublicationYear "2014" @default.
- W2033619005 type Work @default.
- W2033619005 sameAs 2033619005 @default.
- W2033619005 citedByCount "26" @default.
- W2033619005 countsByYear W20336190052015 @default.
- W2033619005 countsByYear W20336190052016 @default.
- W2033619005 countsByYear W20336190052017 @default.
- W2033619005 countsByYear W20336190052018 @default.
- W2033619005 countsByYear W20336190052019 @default.
- W2033619005 countsByYear W20336190052020 @default.
- W2033619005 countsByYear W20336190052021 @default.
- W2033619005 countsByYear W20336190052022 @default.