FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033641844> ?p ?o ?g. }

• W2033641844 endingPage "326" @default.
• W2033641844 startingPage "312" @default.
• W2033641844 abstract "We have previously shown that suppressor-T-cell (TS) activity in the spleens of autoimmune MRL/Mp-lpr/lpr (MRL/l) mice is increased after 2 months of age. The TS suppress the in vitro primary IgM response to the thymus-dependent (TD) antigen sheep erythrocytes (SRBC) of B and T cells from young congenic MRL/Mp-+/+ (MRL/n) mice which lack the lymphoproliferation (lpr) gene. The TS are nylon wool nonadherent, Thy 1.2 positive, and radiation sensitive. The studies presented here were done to further characterize the TS and to attempt to determine the mechanism of action of these cells. We found that increased TS activity was also present in the proliferating lymph nodes of old MRL/l mice but not in lymph nodes of young MRL/l or MRL/n mice. The splenic TS equally suppressed the primary IgM SRBC response of both young MRL/l and MRL/n B and T cells, indicating that MRL/l SRBC-specific B and T cells are not resistant to suppression. The IgM response of MRL/n B and T cells to the T-independent (TI) antigen trinitrophenyl conjugated to Brucella abortus (TNP-BA) was not suppressed by the TS, although the IgM response to TNP was suppressed when TNP was coupled to the TD carrier SRBC. The results of kinetics studies of TS expression showed that when the TS were added on Day 0 of culture the SRBC response was suppressed as early as Day 2 of culture; however, when the TS were added on Days 1, 2, or 3 of culture, the suppression was reduced. The TS suppressed the in vitro memory IgG response of spleen cells from MRL/n mice which had been primed with SRBC; the memory IgG responses of spleen cells from MRL/l mice were variably suppressed. Taken together, these results suggest that the TS suppress TH function in early events of antibody production and that some activated B or T cells may be resistant to the effects of the TS. Increased TS activity was not present in the spleens of aged New Zealand Black X NZ White (NZB/W) F1 mice. Possible reasons for the presence of increased TS activity in MRL/l mice and its relation to autoimmune disease is discussed." @default.
• W2033641844 created "2016-06-24" @default.
• W2033641844 creator A5055977849 @default.
• W2033641844 date "1985-12-01" @default.
• W2033641844 modified "2023-09-23" @default.
• W2033641844 title "Suppressor T-cell activity in MRL/Mp-lpr/lpr mice: Differential effects on primary and memory antibody responses of MRL/Mp-lpr/lpr and MRL/Mp-+/+ spleen cells to thymus dependent and thymus independent antigens in vitro" @default.
• W2033641844 cites W1487959697 @default.
• W2033641844 cites W1520615671 @default.
• W2033641844 cites W1550312369 @default.
• W2033641844 cites W1553677723 @default.
• W2033641844 cites W1554817242 @default.
• W2033641844 cites W1562717001 @default.
• W2033641844 cites W1572093798 @default.
• W2033641844 cites W1575948303 @default.
• W2033641844 cites W1641685097 @default.
• W2033641844 cites W1779504031 @default.
• W2033641844 cites W1809437764 @default.
• W2033641844 cites W1841619397 @default.
• W2033641844 cites W1901578042 @default.
• W2033641844 cites W1965995080 @default.
• W2033641844 cites W1975649472 @default.
• W2033641844 cites W1975651602 @default.
• W2033641844 cites W1994178431 @default.
• W2033641844 cites W2002947217 @default.
• W2033641844 cites W2006979362 @default.
• W2033641844 cites W2017881415 @default.
• W2033641844 cites W2029547538 @default.
• W2033641844 cites W2037760841 @default.
• W2033641844 cites W2046690158 @default.
• W2033641844 cites W2072363643 @default.
• W2033641844 cites W2073632063 @default.
• W2033641844 cites W2084093106 @default.
• W2033641844 cites W2085079885 @default.
• W2033641844 cites W2104379615 @default.
• W2033641844 cites W2105556027 @default.
• W2033641844 cites W2134533879 @default.
• W2033641844 cites W2135417063 @default.
• W2033641844 cites W2142269895 @default.
• W2033641844 cites W2142360671 @default.
• W2033641844 cites W2146561639 @default.
• W2033641844 cites W2151772383 @default.
• W2033641844 cites W2152405804 @default.
• W2033641844 cites W2154230619 @default.
• W2033641844 cites W2155246243 @default.
• W2033641844 cites W2319153630 @default.
• W2033641844 cites W2397124666 @default.
• W2033641844 cites W2401576373 @default.
• W2033641844 cites W2413632949 @default.
• W2033641844 cites W4313316379 @default.
• W2033641844 cites W4313339386 @default.
• W2033641844 doi "https://doi.org/10.1016/0008-8749(85)90363-6" @default.
• W2033641844 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/2943418" @default.
• W2033641844 hasPublicationYear "1985" @default.
• W2033641844 type Work @default.
• W2033641844 sameAs 2033641844 @default.
• W2033641844 citedByCount "6" @default.
• W2033641844 crossrefType "journal-article" @default.
• W2033641844 hasAuthorship W2033641844A5055977849 @default.
• W2033641844 hasConcept C104317684 @default.
• W2033641844 hasConcept C126322002 @default.
• W2033641844 hasConcept C134018914 @default.
• W2033641844 hasConcept C147483822 @default.
• W2033641844 hasConcept C153911025 @default.
• W2033641844 hasConcept C159654299 @default.
• W2033641844 hasConcept C179185449 @default.
• W2033641844 hasConcept C203014093 @default.
• W2033641844 hasConcept C2776090121 @default.
• W2033641844 hasConcept C2780931953 @default.
• W2033641844 hasConcept C55493867 @default.
• W2033641844 hasConcept C71924100 @default.
• W2033641844 hasConcept C84951073 @default.
• W2033641844 hasConcept C86803240 @default.
• W2033641844 hasConcept C8891405 @default.
• W2033641844 hasConceptScore W2033641844C104317684 @default.
• W2033641844 hasConceptScore W2033641844C126322002 @default.
• W2033641844 hasConceptScore W2033641844C134018914 @default.
• W2033641844 hasConceptScore W2033641844C147483822 @default.
• W2033641844 hasConceptScore W2033641844C153911025 @default.
• W2033641844 hasConceptScore W2033641844C159654299 @default.
• W2033641844 hasConceptScore W2033641844C179185449 @default.
• W2033641844 hasConceptScore W2033641844C203014093 @default.
• W2033641844 hasConceptScore W2033641844C2776090121 @default.
• W2033641844 hasConceptScore W2033641844C2780931953 @default.
• W2033641844 hasConceptScore W2033641844C55493867 @default.
• W2033641844 hasConceptScore W2033641844C71924100 @default.
• W2033641844 hasConceptScore W2033641844C84951073 @default.
• W2033641844 hasConceptScore W2033641844C86803240 @default.
• W2033641844 hasConceptScore W2033641844C8891405 @default.
• W2033641844 hasIssue "2" @default.
• W2033641844 hasLocation W20336418441 @default.
• W2033641844 hasLocation W20336418442 @default.
• W2033641844 hasOpenAccess W2033641844 @default.
• W2033641844 hasPrimaryLocation W20336418441 @default.
• W2033641844 hasRelatedWork W1579075587 @default.
• W2033641844 hasRelatedWork W1973484362 @default.
• W2033641844 hasRelatedWork W1975188916 @default.
• W2033641844 hasRelatedWork W1980119493 @default.
• W2033641844 hasRelatedWork W2040191638 @default.

• next