Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033652547> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W2033652547 endingPage "116" @default.
- W2033652547 startingPage "104" @default.
- W2033652547 abstract "To investigate the microfibrillar organization and structural properties of fibrillin-1, we produced overlapping recombinant peptides in human cells which altogether span the fibrillin-1 molecule. The peptides were purified under non-denaturing conditions and extensive characterization indicated correct folding. The purified proteins were used to map monoclonal antibodies 26, 69 and 201. The binding sites are located at the N-terminal end between amino acid residues 45 and 450 (mAb 26), 451 and 909 (mAb 201) and at the C-terminal end between residues 2093 and 2871 (mAb 69). Immunolocalization of these antibodies to extended beaded structures (microfibrils) demonstrated that the N- and C-terminal ends of fibrillin-1 are located in proximity and on opposite sides of the beads, and more central parts of the molecule are located between the beads. Each epitope is present once between each bead. These data allow two possible models for the organization of fibrillin in microfibrils. However, comparison of distances between antibody binding sites on the recombinant peptides and labeling events in tissue suggests that fibrillin molecules are compacted within their tissue form as microfibrils. Additional analysis of the recombinant peptides provide new information regarding the eight-cysteine motif, a novel domain present in fibrillins and TGF beta binding proteins, and suggest that fibrillins are processed at their N-and C-terminal ends." @default.
- W2033652547 created "2016-06-24" @default.
- W2033652547 creator A5000151570 @default.
- W2033652547 creator A5004362058 @default.
- W2033652547 creator A5028795651 @default.
- W2033652547 creator A5040445442 @default.
- W2033652547 creator A5043749718 @default.
- W2033652547 creator A5063332506 @default.
- W2033652547 creator A5087648838 @default.
- W2033652547 date "1996-04-01" @default.
- W2033652547 modified "2023-10-16" @default.
- W2033652547 title "Fibrillin-1: Organization in Microfibrils and Structural Properties" @default.
- W2033652547 doi "https://doi.org/10.1006/jmbi.1996.0237" @default.
- W2033652547 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/8613981" @default.
- W2033652547 hasPublicationYear "1996" @default.
- W2033652547 type Work @default.
- W2033652547 sameAs 2033652547 @default.
- W2033652547 citedByCount "227" @default.
- W2033652547 countsByYear W20336525472012 @default.
- W2033652547 countsByYear W20336525472013 @default.
- W2033652547 countsByYear W20336525472014 @default.
- W2033652547 countsByYear W20336525472015 @default.
- W2033652547 countsByYear W20336525472016 @default.
- W2033652547 countsByYear W20336525472017 @default.
- W2033652547 countsByYear W20336525472018 @default.
- W2033652547 countsByYear W20336525472019 @default.
- W2033652547 countsByYear W20336525472020 @default.
- W2033652547 countsByYear W20336525472021 @default.
- W2033652547 countsByYear W20336525472022 @default.
- W2033652547 countsByYear W20336525472023 @default.
- W2033652547 crossrefType "journal-article" @default.
- W2033652547 hasAuthorship W2033652547A5000151570 @default.
- W2033652547 hasAuthorship W2033652547A5004362058 @default.
- W2033652547 hasAuthorship W2033652547A5028795651 @default.
- W2033652547 hasAuthorship W2033652547A5040445442 @default.
- W2033652547 hasAuthorship W2033652547A5043749718 @default.
- W2033652547 hasAuthorship W2033652547A5063332506 @default.
- W2033652547 hasAuthorship W2033652547A5087648838 @default.
- W2033652547 hasConcept C104317684 @default.
- W2033652547 hasConcept C12554922 @default.
- W2033652547 hasConcept C159654299 @default.
- W2033652547 hasConcept C167625842 @default.
- W2033652547 hasConcept C185592680 @default.
- W2033652547 hasConcept C189165786 @default.
- W2033652547 hasConcept C195616568 @default.
- W2033652547 hasConcept C2776455902 @default.
- W2033652547 hasConcept C2779251873 @default.
- W2033652547 hasConcept C40767141 @default.
- W2033652547 hasConcept C542903549 @default.
- W2033652547 hasConcept C54355233 @default.
- W2033652547 hasConcept C55493867 @default.
- W2033652547 hasConcept C76334062 @default.
- W2033652547 hasConcept C86803240 @default.
- W2033652547 hasConceptScore W2033652547C104317684 @default.
- W2033652547 hasConceptScore W2033652547C12554922 @default.
- W2033652547 hasConceptScore W2033652547C159654299 @default.
- W2033652547 hasConceptScore W2033652547C167625842 @default.
- W2033652547 hasConceptScore W2033652547C185592680 @default.
- W2033652547 hasConceptScore W2033652547C189165786 @default.
- W2033652547 hasConceptScore W2033652547C195616568 @default.
- W2033652547 hasConceptScore W2033652547C2776455902 @default.
- W2033652547 hasConceptScore W2033652547C2779251873 @default.
- W2033652547 hasConceptScore W2033652547C40767141 @default.
- W2033652547 hasConceptScore W2033652547C542903549 @default.
- W2033652547 hasConceptScore W2033652547C54355233 @default.
- W2033652547 hasConceptScore W2033652547C55493867 @default.
- W2033652547 hasConceptScore W2033652547C76334062 @default.
- W2033652547 hasConceptScore W2033652547C86803240 @default.
- W2033652547 hasIssue "1" @default.
- W2033652547 hasLocation W20336525471 @default.
- W2033652547 hasLocation W20336525472 @default.
- W2033652547 hasOpenAccess W2033652547 @default.
- W2033652547 hasPrimaryLocation W20336525471 @default.
- W2033652547 hasRelatedWork W1541823805 @default.
- W2033652547 hasRelatedWork W2075529332 @default.
- W2033652547 hasRelatedWork W2106365753 @default.
- W2033652547 hasRelatedWork W2107563847 @default.
- W2033652547 hasRelatedWork W2110333540 @default.
- W2033652547 hasRelatedWork W2129032853 @default.
- W2033652547 hasRelatedWork W2131224625 @default.
- W2033652547 hasRelatedWork W2169036518 @default.
- W2033652547 hasRelatedWork W4240669810 @default.
- W2033652547 hasRelatedWork W4323284458 @default.
- W2033652547 hasVolume "258" @default.
- W2033652547 isParatext "false" @default.
- W2033652547 isRetracted "false" @default.
- W2033652547 magId "2033652547" @default.
- W2033652547 workType "article" @default.