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- W2033655554 abstract "Feline defensive rage is a form of aggression occurring in nature in response to a threatening condition and is elicited under laboratory conditions by electrical stimulation of the medial hypothalamus or midbrain periaqueductal gray (PAG). Since it has recently been shown that cytokines can modulate neurotransmitter release, the present study was designed to determine the effects of administration of interleukin 2 (IL-2) into the PAG upon defensive rage elicited from the medial hypothalamus. Microinjections of relatively low doses of IL-2 into the dorsal PAG significantly facilitated defensive rage behavior elicited from the medial hypothalamus. The specificity of this phenomenon was supported by the following findings: (1) IL-2 induced effects were dose- and time-dependent, (2) the facilitative effects of IL-2 could be completely blocked by pre-treatment of the injection site with either anti-IL-2 or anti-IL-2 receptor antibody and (3) IL-2 administration into the PAG showed no effect upon another form of aggression, namely predatory attack, elicited from the lateral hypothalamus. The findings further demonstrated that the effects of IL-2 were mediated by an NK1 receptor mechanism since pre-treatment of the PAG with an NK1 receptor antagonist completely blocked the facilitating effects of IL-2. Immunocytochemical observations supported these findings by demonstrating an extensive pattern of labeling of IL-2Rα in the dorsal PAG. The present study thus demonstrates that IL-2 in the dorsal PAG potentiates defensive rage behavior and is mediated through an NK1 receptor mechanism." @default.
- W2033655554 created "2016-06-24" @default.
- W2033655554 creator A5018179375 @default.
- W2033655554 creator A5085550284 @default.
- W2033655554 date "2006-02-28" @default.
- W2033655554 modified "2023-10-12" @default.
- W2033655554 title "Potentiating role of interleukin 2 (IL-2) receptors in the midbrain periaqueductal gray (PAG) upon defensive rage behavior in the cat: Role of neurokinin NK1 receptors" @default.
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- W2033655554 doi "https://doi.org/10.1016/j.bbr.2005.09.011" @default.
- W2033655554 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/16242788" @default.
- W2033655554 hasPublicationYear "2006" @default.
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