FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033655900> ?p ?o ?g. }

• W2033655900 endingPage "783" @default.
• W2033655900 startingPage "775" @default.
• W2033655900 abstract "Introduction:Met activation by gene amplification and its ligand, hepatocyte growth factor (HGF), imparts resistance to epidermal growth factor receptor (EGFR) tyrosine kinase inhibitors (TKIs) in EGFR-mutant lung cancer. We recently reported that Met activation by HGF stimulates the production of vascular endothelial growth factor (VEGF) and facilitates angiogenesis, which indicates that HGF induces EGFR-TKI resistance and angiogenesis. This study aimed to determine the effect of triple inhibition of EGFR, Met, and angiogenesis on HGF-triggered EGFR-TKI resistance in EGFR-mutant lung cancer.Methods:Three clinically approved drugs, erlotinib (an EGFR inhibitor), crizotinib (an inhibitor of anaplastic lymphoma kinase and Met), and bevacizumab (anti-VEGF antibody), and TAS-115, a novel dual TKI for Met and VEGF receptor 2, were used in this study. EGFR-mutant lung cancer cell lines PC-9, HCC827, and HGF-gene–transfected PC-9 (PC-9/HGF) cells were examined.Results:Crizotinib and TAS-115 inhibited Met phosphorylation and reversed erlotinib resistance and VEGF production triggered by HGF in PC-9 and HCC827 cells in vitro. Bevacizumab and TAS-115 inhibited angiogenesis in PC-9/HGF tumors in vivo. Moreover, the triplet erlotinib, crizotinib, and bevacizumab, or the doublet erlotinib and TAS-115 successfully inhibited PC-9/HGF tumor growth and delayed tumor regrowth associated with sustained tumor vasculature inhibition even after cessation of the treatment.Conclusion:These results suggest that triple inhibition of EGFR, HGF/Met, and VEGF/VEGF receptor 2, by either a triplet of clinical drugs or TAS-115 combined with erlotinib, may be useful for controlling progression of EGFR-mutant lung cancer by reversing EGFR-TKI resistance and for inhibiting angiogenesis." @default.
• W2033655900 created "2016-06-24" @default.
• W2033655900 creator A5005841480 @default.
• W2033655900 creator A5016499405 @default.
• W2033655900 creator A5017882443 @default.
• W2033655900 creator A5018773565 @default.
• W2033655900 creator A5021107925 @default.
• W2033655900 creator A5025302913 @default.
• W2033655900 creator A5033262704 @default.
• W2033655900 creator A5045660079 @default.
• W2033655900 creator A5052076883 @default.
• W2033655900 creator A5058625421 @default.
• W2033655900 creator A5078464592 @default.
• W2033655900 creator A5086218839 @default.
• W2033655900 creator A5088194700 @default.
• W2033655900 date "2014-06-01" @default.
• W2033655900 modified "2023-10-16" @default.
• W2033655900 title "Triple Inhibition of EGFR, Met, and VEGF Suppresses Regrowth of HGF-Triggered, Erlotinib-Resistant Lung Cancer Harboring an EGFR Mutation" @default.
• W2033655900 cites W1977401929 @default.
• W2033655900 cites W1983774108 @default.
• W2033655900 cites W1988939419 @default.
• W2033655900 cites W1995472430 @default.
• W2033655900 cites W1998971866 @default.
• W2033655900 cites W1999025555 @default.
• W2033655900 cites W2002697796 @default.
• W2033655900 cites W2002937040 @default.
• W2033655900 cites W2003984225 @default.
• W2033655900 cites W2018628280 @default.
• W2033655900 cites W2020766122 @default.
• W2033655900 cites W2039013742 @default.
• W2033655900 cites W2043696829 @default.
• W2033655900 cites W2082600674 @default.
• W2033655900 cites W2087955215 @default.
• W2033655900 cites W2089858549 @default.
• W2033655900 cites W2090029719 @default.
• W2033655900 cites W2101918466 @default.
• W2033655900 cites W2102960957 @default.
• W2033655900 cites W2104830962 @default.
• W2033655900 cites W2112602910 @default.
• W2033655900 cites W2115269346 @default.
• W2033655900 cites W2115549126 @default.
• W2033655900 cites W2116531093 @default.
• W2033655900 cites W2119351872 @default.
• W2033655900 cites W2123027432 @default.
• W2033655900 cites W2124808167 @default.
• W2033655900 cites W2130488043 @default.
• W2033655900 cites W2139236349 @default.
• W2033655900 cites W2140088548 @default.
• W2033655900 cites W2148911877 @default.
• W2033655900 cites W2153064305 @default.
• W2033655900 cites W2161821474 @default.
• W2033655900 cites W2162352067 @default.
• W2033655900 cites W2170476872 @default.
• W2033655900 doi "https://doi.org/10.1097/jto.0000000000000170" @default.
• W2033655900 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4132034" @default.
• W2033655900 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/24828661" @default.
• W2033655900 hasPublicationYear "2014" @default.
• W2033655900 type Work @default.
• W2033655900 sameAs 2033655900 @default.
• W2033655900 citedByCount "33" @default.
• W2033655900 countsByYear W20336559002014 @default.
• W2033655900 countsByYear W20336559002015 @default.
• W2033655900 countsByYear W20336559002016 @default.
• W2033655900 countsByYear W20336559002017 @default.
• W2033655900 countsByYear W20336559002018 @default.
• W2033655900 countsByYear W20336559002019 @default.
• W2033655900 countsByYear W20336559002020 @default.
• W2033655900 countsByYear W20336559002021 @default.
• W2033655900 countsByYear W20336559002022 @default.
• W2033655900 crossrefType "journal-article" @default.
• W2033655900 hasAuthorship W2033655900A5005841480 @default.
• W2033655900 hasAuthorship W2033655900A5016499405 @default.
• W2033655900 hasAuthorship W2033655900A5017882443 @default.
• W2033655900 hasAuthorship W2033655900A5018773565 @default.
• W2033655900 hasAuthorship W2033655900A5021107925 @default.
• W2033655900 hasAuthorship W2033655900A5025302913 @default.
• W2033655900 hasAuthorship W2033655900A5033262704 @default.
• W2033655900 hasAuthorship W2033655900A5045660079 @default.
• W2033655900 hasAuthorship W2033655900A5052076883 @default.
• W2033655900 hasAuthorship W2033655900A5058625421 @default.
• W2033655900 hasAuthorship W2033655900A5078464592 @default.
• W2033655900 hasAuthorship W2033655900A5086218839 @default.
• W2033655900 hasAuthorship W2033655900A5088194700 @default.
• W2033655900 hasBestOaLocation W20336559001 @default.
• W2033655900 hasConcept C117643217 @default.
• W2033655900 hasConcept C121608353 @default.
• W2033655900 hasConcept C126322002 @default.
• W2033655900 hasConcept C167734588 @default.
• W2033655900 hasConcept C170493617 @default.
• W2033655900 hasConcept C2776056115 @default.
• W2033655900 hasConcept C2776232967 @default.
• W2033655900 hasConcept C2776256026 @default.
• W2033655900 hasConcept C2776694085 @default.
• W2033655900 hasConcept C2776996007 @default.
• W2033655900 hasConcept C2777025900 @default.
• W2033655900 hasConcept C2777506169 @default.
• W2033655900 hasConcept C2777802072 @default.
• W2033655900 hasConcept C2778087573 @default.

• next