FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033665384> ?p ?o ?g. }

• W2033665384 endingPage "457" @default.
• W2033665384 startingPage "449" @default.
• W2033665384 abstract "Visceral obesity is intimately associated with metabolic disease and adverse health outcomes. However, a direct association between increasing amounts of visceral fat and end-organ inflammation and scarring has not been demonstrated. We examined the association between visceral fat and liver inflammation in patients with nonalcoholic fatty liver disease (NAFLD) to delineate the importance of visceral fat to progressive steatohepatitis and hence the inflammatory pathogenesis of the metabolic syndrome. We undertook a cross-sectional, proof of concept study in 38 consecutive adults with NAFLD at a tertiary liver clinic. All subjects had a complete physical examination, anthropometric assessment, and fasting blood tests on the day of liver biopsy. Abdominal fat volumes were assessed by magnetic resonance imaging within 2 weeks of liver biopsy. The extent of hepatic inflammation and fibrosis augmented incrementally with increases in visceral fat (P < 0.01). For each 1% increase in visceral fat, the odds ratio for increasing liver inflammation and fibrosis was 2.4 (confidence interval [CI]: 1.3-4.2) and 3.5 (CI: 1.7-7.1), respectively. Visceral fat remained an independent predictor of advanced steatohepatitis (odds ratio [OR] 2.1, CI: 1.1-4.2, P = 0.05) and fibrosis (OR 2.9, CI: 1.4-6.3, P = 0.006) even when controlled for insulin resistance and hepatic steatosis. Interleukin-6 (IL-6) levels, which correlated with visceral fat, also independently predicted increasing liver inflammation. Visceral fat was associated with all components of the metabolic syndrome. Conclusion: Visceral fat is directly associated with liver inflammation and fibrosis independent of insulin resistance and hepatic steatosis. Visceral fat should therefore be a central target for future interventions in nonalcoholic steatohepatitis and indeed all metabolic disease. (HEPATOLOGY 2008.)" @default.
• W2033665384 created "2016-06-24" @default.
• W2033665384 creator A5011865871 @default.
• W2033665384 creator A5017494597 @default.
• W2033665384 creator A5027069410 @default.
• W2033665384 creator A5027877296 @default.
• W2033665384 creator A5048056930 @default.
• W2033665384 creator A5051277696 @default.
• W2033665384 creator A5052816965 @default.
• W2033665384 creator A5062863226 @default.
• W2033665384 creator A5079248131 @default.
• W2033665384 creator A5086908096 @default.
• W2033665384 date "2008-08-01" @default.
• W2033665384 modified "2023-10-18" @default.
• W2033665384 title "Visceral fat: A key mediator of steatohepatitis in metabolic liver disease" @default.
• W2033665384 cites W1943668942 @default.
• W2033665384 cites W1972051907 @default.
• W2033665384 cites W1982594212 @default.
• W2033665384 cites W1987427880 @default.
• W2033665384 cites W1990438961 @default.
• W2033665384 cites W1991334358 @default.
• W2033665384 cites W1995000970 @default.
• W2033665384 cites W2003380115 @default.
• W2033665384 cites W2010374889 @default.
• W2033665384 cites W2023181043 @default.
• W2033665384 cites W2023294484 @default.
• W2033665384 cites W2033740553 @default.
• W2033665384 cites W2036103276 @default.
• W2033665384 cites W2042339399 @default.
• W2033665384 cites W2048577023 @default.
• W2033665384 cites W2050767863 @default.
• W2033665384 cites W2062560800 @default.
• W2033665384 cites W2065897618 @default.
• W2033665384 cites W2074873220 @default.
• W2033665384 cites W2087829753 @default.
• W2033665384 cites W2090826122 @default.
• W2033665384 cites W2095726149 @default.
• W2033665384 cites W2103156933 @default.
• W2033665384 cites W2103714496 @default.
• W2033665384 cites W2106819547 @default.
• W2033665384 cites W2107732097 @default.
• W2033665384 cites W2124582484 @default.
• W2033665384 cites W2128178707 @default.
• W2033665384 cites W2131541226 @default.
• W2033665384 cites W2160234571 @default.
• W2033665384 cites W2615637571 @default.
• W2033665384 cites W4230280576 @default.
• W2033665384 cites W4238497443 @default.
• W2033665384 doi "https://doi.org/10.1002/hep.22350" @default.
• W2033665384 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18627003" @default.
• W2033665384 hasPublicationYear "2008" @default.
• W2033665384 type Work @default.
• W2033665384 sameAs 2033665384 @default.
• W2033665384 citedByCount "501" @default.
• W2033665384 countsByYear W20336653842012 @default.
• W2033665384 countsByYear W20336653842013 @default.
• W2033665384 countsByYear W20336653842014 @default.
• W2033665384 countsByYear W20336653842015 @default.
• W2033665384 countsByYear W20336653842016 @default.
• W2033665384 countsByYear W20336653842017 @default.
• W2033665384 countsByYear W20336653842018 @default.
• W2033665384 countsByYear W20336653842019 @default.
• W2033665384 countsByYear W20336653842020 @default.
• W2033665384 countsByYear W20336653842021 @default.
• W2033665384 countsByYear W20336653842022 @default.
• W2033665384 countsByYear W20336653842023 @default.
• W2033665384 crossrefType "journal-article" @default.
• W2033665384 hasAuthorship W2033665384A5011865871 @default.
• W2033665384 hasAuthorship W2033665384A5017494597 @default.
• W2033665384 hasAuthorship W2033665384A5027069410 @default.
• W2033665384 hasAuthorship W2033665384A5027877296 @default.
• W2033665384 hasAuthorship W2033665384A5048056930 @default.
• W2033665384 hasAuthorship W2033665384A5051277696 @default.
• W2033665384 hasAuthorship W2033665384A5052816965 @default.
• W2033665384 hasAuthorship W2033665384A5062863226 @default.
• W2033665384 hasAuthorship W2033665384A5079248131 @default.
• W2033665384 hasAuthorship W2033665384A5086908096 @default.
• W2033665384 hasBestOaLocation W20336653841 @default.
• W2033665384 hasConcept C126322002 @default.
• W2033665384 hasConcept C134018914 @default.
• W2033665384 hasConcept C142724271 @default.
• W2033665384 hasConcept C156957248 @default.
• W2033665384 hasConcept C2775934546 @default.
• W2033665384 hasConcept C2776175330 @default.
• W2033665384 hasConcept C2776914184 @default.
• W2033665384 hasConcept C2776954865 @default.
• W2033665384 hasConcept C2777075537 @default.
• W2033665384 hasConcept C2777391703 @default.
• W2033665384 hasConcept C2777766500 @default.
• W2033665384 hasConcept C2778772119 @default.
• W2033665384 hasConcept C2779134260 @default.
• W2033665384 hasConcept C2779478299 @default.
• W2033665384 hasConcept C2780559512 @default.
• W2033665384 hasConcept C2780578515 @default.
• W2033665384 hasConcept C2909124604 @default.
• W2033665384 hasConcept C3020796190 @default.
• W2033665384 hasConcept C511355011 @default.
• W2033665384 hasConcept C71924100 @default.

• next