FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033669506> ?p ?o ?g. }

• W2033669506 abstract "The median survival of patients with glioblastoma multiforme (GBM) remains poor. Innovative immunotherapies with dendritic cell (DC) vaccination might be combined with standard temozolomide (TMZ) treatment. Here, we evaluated the influence of TMZ on the phenotype and function of DCs and CD8+ T cells. DCs were generated from the peripheral blood of healthy volunteers (HVs) and GBM patients. DCs were analyzed by light microscopy and flow cytometry. Phago­cytic activity was tested by FITC-dextran engulfment. Mixed lymphocyte peptide cultures were followed by enzyme-linked immunospot (ELISPOT) and flow cytometry assays. TMZ was added to DC and T cell cultures at concentrations up to 500 µM. Mature DCs were generated from HVs and GBM patients. Cells displayed a typical DC morphology and a mature DC phenotype. Expression of CD209 was even higher in DCs generated from patients under therapy than from HVs (75.2 vs. 51.1%). In contrast, CD40 (1.1 vs. 13.5%) and BDCA4 (26.5 vs. 52.9%) were lower expressed in GBM patients at time of diagnosis. Immature DCs showed high phagocytic activity. Addition of TMZ at concentrations up to 50 µM did neither impair the phenotype nor the function of DCs. In ELISPOT and flow cytometry assays, no impairment of CD8+ T cell responses to viral antigens could be observed. Taken together, TMZ does not impair the function of either DCs or the CD8+ T cells." @default.
• W2033669506 created "2016-06-24" @default.
• W2033669506 creator A5003733935 @default.
• W2033669506 creator A5005594026 @default.
• W2033669506 creator A5013156445 @default.
• W2033669506 creator A5017514499 @default.
• W2033669506 creator A5025055846 @default.
• W2033669506 creator A5025764940 @default.
• W2033669506 creator A5031568690 @default.
• W2033669506 creator A5045408728 @default.
• W2033669506 creator A5057369914 @default.
• W2033669506 creator A5084138424 @default.
• W2033669506 date "2011-11-23" @default.
• W2033669506 modified "2023-09-30" @default.
• W2033669506 title "Therapeutical doses of temozolomide do not impair the function of dendritic cells and CD8+ T cells" @default.
• W2033669506 cites W1499491325 @default.
• W2033669506 cites W1819850574 @default.
• W2033669506 cites W1968830740 @default.
• W2033669506 cites W1987760594 @default.
• W2033669506 cites W1989207092 @default.
• W2033669506 cites W2019265097 @default.
• W2033669506 cites W2033488399 @default.
• W2033669506 cites W2035057039 @default.
• W2033669506 cites W2036678109 @default.
• W2033669506 cites W2042879110 @default.
• W2033669506 cites W2048244201 @default.
• W2033669506 cites W2052457630 @default.
• W2033669506 cites W2053668604 @default.
• W2033669506 cites W2069382319 @default.
• W2033669506 cites W2069771820 @default.
• W2033669506 cites W2075180002 @default.
• W2033669506 cites W2075287181 @default.
• W2033669506 cites W2094735628 @default.
• W2033669506 cites W2098263349 @default.
• W2033669506 cites W2100328852 @default.
• W2033669506 cites W2115862526 @default.
• W2033669506 cites W2117735567 @default.
• W2033669506 cites W2125984728 @default.
• W2033669506 cites W2127980102 @default.
• W2033669506 cites W2127982431 @default.
• W2033669506 cites W2128961069 @default.
• W2033669506 cites W2129387595 @default.
• W2033669506 cites W2135594199 @default.
• W2033669506 cites W2135811373 @default.
• W2033669506 cites W2141699748 @default.
• W2033669506 cites W2154866876 @default.
• W2033669506 cites W2158681922 @default.
• W2033669506 cites W2162630386 @default.
• W2033669506 cites W2163755709 @default.
• W2033669506 cites W2166112009 @default.
• W2033669506 cites W2166637991 @default.
• W2033669506 doi "https://doi.org/10.3892/ijo.2011.1269" @default.
• W2033669506 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/22134728" @default.
• W2033669506 hasPublicationYear "2011" @default.
• W2033669506 type Work @default.
• W2033669506 sameAs 2033669506 @default.
• W2033669506 citedByCount "3" @default.
• W2033669506 countsByYear W20336695062015 @default.
• W2033669506 countsByYear W20336695062020 @default.
• W2033669506 crossrefType "journal-article" @default.
• W2033669506 hasAuthorship W2033669506A5003733935 @default.
• W2033669506 hasAuthorship W2033669506A5005594026 @default.
• W2033669506 hasAuthorship W2033669506A5013156445 @default.
• W2033669506 hasAuthorship W2033669506A5017514499 @default.
• W2033669506 hasAuthorship W2033669506A5025055846 @default.
• W2033669506 hasAuthorship W2033669506A5025764940 @default.
• W2033669506 hasAuthorship W2033669506A5031568690 @default.
• W2033669506 hasAuthorship W2033669506A5045408728 @default.
• W2033669506 hasAuthorship W2033669506A5057369914 @default.
• W2033669506 hasAuthorship W2033669506A5084138424 @default.
• W2033669506 hasBestOaLocation W20336695061 @default.
• W2033669506 hasConcept C147483822 @default.
• W2033669506 hasConcept C154317977 @default.
• W2033669506 hasConcept C167672396 @default.
• W2033669506 hasConcept C196166836 @default.
• W2033669506 hasConcept C202751555 @default.
• W2033669506 hasConcept C203014093 @default.
• W2033669506 hasConcept C2776090121 @default.
• W2033669506 hasConcept C2777389519 @default.
• W2033669506 hasConcept C2778170410 @default.
• W2033669506 hasConcept C2778227246 @default.
• W2033669506 hasConcept C2779053233 @default.
• W2033669506 hasConcept C502942594 @default.
• W2033669506 hasConcept C553184892 @default.
• W2033669506 hasConcept C55493867 @default.
• W2033669506 hasConcept C86803240 @default.
• W2033669506 hasConcept C8891405 @default.
• W2033669506 hasConceptScore W2033669506C147483822 @default.
• W2033669506 hasConceptScore W2033669506C154317977 @default.
• W2033669506 hasConceptScore W2033669506C167672396 @default.
• W2033669506 hasConceptScore W2033669506C196166836 @default.
• W2033669506 hasConceptScore W2033669506C202751555 @default.
• W2033669506 hasConceptScore W2033669506C203014093 @default.
• W2033669506 hasConceptScore W2033669506C2776090121 @default.
• W2033669506 hasConceptScore W2033669506C2777389519 @default.
• W2033669506 hasConceptScore W2033669506C2778170410 @default.
• W2033669506 hasConceptScore W2033669506C2778227246 @default.
• W2033669506 hasConceptScore W2033669506C2779053233 @default.
• W2033669506 hasConceptScore W2033669506C502942594 @default.
• W2033669506 hasConceptScore W2033669506C553184892 @default.

• next