Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033670698> ?p ?o ?g. }
- W2033670698 endingPage "4608" @default.
- W2033670698 startingPage "4581" @default.
- W2033670698 abstract "The concept of eradication of the Human Immune Deficiency Virus (HIV) from infected patients has gained much attention in the last few years. While combination Anti-Retroviral Therapy (c-ART) has been extremely effective in suppressing viral replication, it is not curative. This is due to the presence of a reservoir of latent HIV infected cells, which persist in the presence of c-ART. Recently, pharmaceutical approaches have focused on the development of molecules able to induce HIV-1 replication from latently infected cells in order to render them susceptible to viral cytopathic effects and host immune responses. Alternative pathways and transcription complexes function to regulate the activity of the HIV promoter and might serve as molecular targets for compounds to activate latent HIV. A combined therapy coupling various depressors and activators will likely be the most effective in promoting HIV replication while avoiding pleiotropic effects at the cellular level. Moreover, in light of differences among HIV subtypes and variability in integration sites, the combination of multiple agents targeting multiple pathways will increase likelihood of therapeutic effectiveness and prevent mutational escape. This review provides an overview of the mechanisms that can be targeted to induce HIV activation focusing on potential combinatorial approaches." @default.
- W2033670698 created "2016-06-24" @default.
- W2033670698 creator A5002888060 @default.
- W2033670698 creator A5077282469 @default.
- W2033670698 date "2014-11-21" @default.
- W2033670698 modified "2023-09-23" @default.
- W2033670698 title "HIV Eradication: Combinatorial Approaches to Activate Latent Viruses" @default.
- W2033670698 cites W1487277447 @default.
- W2033670698 cites W1497870368 @default.
- W2033670698 cites W1527634862 @default.
- W2033670698 cites W1590436404 @default.
- W2033670698 cites W1598902601 @default.
- W2033670698 cites W1602975132 @default.
- W2033670698 cites W1756592162 @default.
- W2033670698 cites W1869438582 @default.
- W2033670698 cites W1964459553 @default.
- W2033670698 cites W1964849737 @default.
- W2033670698 cites W1965266980 @default.
- W2033670698 cites W1966066354 @default.
- W2033670698 cites W1966121663 @default.
- W2033670698 cites W1967517704 @default.
- W2033670698 cites W1968819082 @default.
- W2033670698 cites W1971512098 @default.
- W2033670698 cites W1973398091 @default.
- W2033670698 cites W1973462980 @default.
- W2033670698 cites W1973694997 @default.
- W2033670698 cites W1976257926 @default.
- W2033670698 cites W1980223851 @default.
- W2033670698 cites W1980668957 @default.
- W2033670698 cites W1981915772 @default.
- W2033670698 cites W1982561231 @default.
- W2033670698 cites W1982884889 @default.
- W2033670698 cites W1991342850 @default.
- W2033670698 cites W1992577008 @default.
- W2033670698 cites W1992761009 @default.
- W2033670698 cites W1993214867 @default.
- W2033670698 cites W1996604523 @default.
- W2033670698 cites W1998093208 @default.
- W2033670698 cites W2000337153 @default.
- W2033670698 cites W2000596495 @default.
- W2033670698 cites W2001235690 @default.
- W2033670698 cites W2001356550 @default.
- W2033670698 cites W2004040286 @default.
- W2033670698 cites W2004191627 @default.
- W2033670698 cites W2004223360 @default.
- W2033670698 cites W2006419043 @default.
- W2033670698 cites W2006765654 @default.
- W2033670698 cites W2009227393 @default.
- W2033670698 cites W2009334076 @default.
- W2033670698 cites W2011208161 @default.
- W2033670698 cites W2011630381 @default.
- W2033670698 cites W2013051750 @default.
- W2033670698 cites W2013824955 @default.
- W2033670698 cites W2014017310 @default.
- W2033670698 cites W2020404213 @default.
- W2033670698 cites W2022045441 @default.
- W2033670698 cites W2023121370 @default.
- W2033670698 cites W2026814484 @default.
- W2033670698 cites W2028613789 @default.
- W2033670698 cites W2031708680 @default.
- W2033670698 cites W2034947923 @default.
- W2033670698 cites W2035813371 @default.
- W2033670698 cites W2035947707 @default.
- W2033670698 cites W2036890038 @default.
- W2033670698 cites W2038017537 @default.
- W2033670698 cites W2038598840 @default.
- W2033670698 cites W2046159404 @default.
- W2033670698 cites W2046447595 @default.
- W2033670698 cites W2047300635 @default.
- W2033670698 cites W2047900444 @default.
- W2033670698 cites W2049874714 @default.
- W2033670698 cites W2051269276 @default.
- W2033670698 cites W2052173238 @default.
- W2033670698 cites W2053540546 @default.
- W2033670698 cites W2054343189 @default.
- W2033670698 cites W2055142955 @default.
- W2033670698 cites W2055796578 @default.
- W2033670698 cites W2056646254 @default.
- W2033670698 cites W2057754959 @default.
- W2033670698 cites W2059894297 @default.
- W2033670698 cites W2061005894 @default.
- W2033670698 cites W2063628696 @default.
- W2033670698 cites W2064561918 @default.
- W2033670698 cites W2064743809 @default.
- W2033670698 cites W2065609322 @default.
- W2033670698 cites W2066013688 @default.
- W2033670698 cites W2066848476 @default.
- W2033670698 cites W2067938485 @default.
- W2033670698 cites W2068816405 @default.
- W2033670698 cites W2072401586 @default.
- W2033670698 cites W2076805613 @default.
- W2033670698 cites W2079003739 @default.
- W2033670698 cites W2079026626 @default.
- W2033670698 cites W2080166804 @default.
- W2033670698 cites W2081064241 @default.
- W2033670698 cites W2081494228 @default.
- W2033670698 cites W2081540048 @default.
- W2033670698 cites W2081550460 @default.