Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033687798> ?p ?o ?g. }
- W2033687798 endingPage "97" @default.
- W2033687798 startingPage "84" @default.
- W2033687798 abstract "Inhibition of HIV replication initially targeted viral enzymes, which are exclusively expressed by the virus and not present in the human cell. The development of reverse transcriptase (RT) inhibitors started with the discovery of antiretroviral activity of the nucleoside analog zidovudine in March 1987. Currently, six major classes of antiretroviral drugs are used for the treatment of HIV-infected patients: the RT inhibitors, nucleoside inhibitors and nonnucleoside inhibitors, the protease inhibitors, the integrase inhibitor raltegravir, the fusion inhibitor enfuvirtide (T-20), and the chemokine receptor 5 antagonist maraviroc. A seventh class, the maturation inhibitors, has not yet been approved as their effectiveness is impaired by HIV-1 polymorphisms naturally occurring in 30–40% of HIV-1 therapy-naive isolates. The use of antiretroviral combination therapy has proven to be effective in delaying progression to AIDS and to reconstitute the immune system of HIV-infected individuals. During the last 5 years, the introduction of the newest antiretrovirals has increased treatment efficacy tremendously. However, the development and accumulation of resistance to all antiretroviral drug classes are still a major problem. Additional targets will have to be defined to achieve the ultimate goal: the eradication of the virus from the infected human body." @default.
- W2033687798 created "2016-06-24" @default.
- W2033687798 creator A5042917012 @default.
- W2033687798 creator A5091171397 @default.
- W2033687798 date "2012-01-01" @default.
- W2033687798 modified "2023-10-06" @default.
- W2033687798 title "Targets for Inhibition of HIV Replication: Entry, Enzyme Action, Release and Maturation" @default.
- W2033687798 cites W1491953219 @default.
- W2033687798 cites W1500789577 @default.
- W2033687798 cites W1523087205 @default.
- W2033687798 cites W1559159023 @default.
- W2033687798 cites W1560229472 @default.
- W2033687798 cites W1607763164 @default.
- W2033687798 cites W171233394 @default.
- W2033687798 cites W1804821915 @default.
- W2033687798 cites W1830489709 @default.
- W2033687798 cites W1959324364 @default.
- W2033687798 cites W1966261980 @default.
- W2033687798 cites W1970307257 @default.
- W2033687798 cites W1973123797 @default.
- W2033687798 cites W1973787553 @default.
- W2033687798 cites W1974224443 @default.
- W2033687798 cites W1974543288 @default.
- W2033687798 cites W1975790752 @default.
- W2033687798 cites W1976074894 @default.
- W2033687798 cites W1976819270 @default.
- W2033687798 cites W1979033897 @default.
- W2033687798 cites W1985722970 @default.
- W2033687798 cites W1987372627 @default.
- W2033687798 cites W1991539551 @default.
- W2033687798 cites W1993641427 @default.
- W2033687798 cites W1998992970 @default.
- W2033687798 cites W1999071682 @default.
- W2033687798 cites W2000625719 @default.
- W2033687798 cites W2001609473 @default.
- W2033687798 cites W2007831756 @default.
- W2033687798 cites W2008630621 @default.
- W2033687798 cites W2010294404 @default.
- W2033687798 cites W2011592728 @default.
- W2033687798 cites W2012071832 @default.
- W2033687798 cites W2018545343 @default.
- W2033687798 cites W2021008862 @default.
- W2033687798 cites W2023829232 @default.
- W2033687798 cites W2024569169 @default.
- W2033687798 cites W2025444624 @default.
- W2033687798 cites W2025622116 @default.
- W2033687798 cites W2026034630 @default.
- W2033687798 cites W2027642737 @default.
- W2033687798 cites W2028980458 @default.
- W2033687798 cites W2030017358 @default.
- W2033687798 cites W2030354725 @default.
- W2033687798 cites W2031828918 @default.
- W2033687798 cites W2036499259 @default.
- W2033687798 cites W2051785641 @default.
- W2033687798 cites W2052200516 @default.
- W2033687798 cites W2052991207 @default.
- W2033687798 cites W2053125329 @default.
- W2033687798 cites W2053570554 @default.
- W2033687798 cites W2053642088 @default.
- W2033687798 cites W2054996337 @default.
- W2033687798 cites W2057774530 @default.
- W2033687798 cites W2058181494 @default.
- W2033687798 cites W2058884419 @default.
- W2033687798 cites W2059955999 @default.
- W2033687798 cites W2062229947 @default.
- W2033687798 cites W2062388675 @default.
- W2033687798 cites W2063054463 @default.
- W2033687798 cites W2066371161 @default.
- W2033687798 cites W2067241941 @default.
- W2033687798 cites W2070663444 @default.
- W2033687798 cites W2073273867 @default.
- W2033687798 cites W2076322352 @default.
- W2033687798 cites W2076965602 @default.
- W2033687798 cites W2077307357 @default.
- W2033687798 cites W2082465545 @default.
- W2033687798 cites W2085934210 @default.
- W2033687798 cites W2090630729 @default.
- W2033687798 cites W2091535856 @default.
- W2033687798 cites W2091847883 @default.
- W2033687798 cites W2092013007 @default.
- W2033687798 cites W2092178133 @default.
- W2033687798 cites W2095780507 @default.
- W2033687798 cites W2097744772 @default.
- W2033687798 cites W2104318155 @default.
- W2033687798 cites W2106662283 @default.
- W2033687798 cites W2109532808 @default.
- W2033687798 cites W2110838631 @default.
- W2033687798 cites W2115906128 @default.
- W2033687798 cites W2116801949 @default.
- W2033687798 cites W2117098951 @default.
- W2033687798 cites W2118583955 @default.
- W2033687798 cites W2122102984 @default.
- W2033687798 cites W2122579172 @default.
- W2033687798 cites W2124671510 @default.
- W2033687798 cites W2128618062 @default.
- W2033687798 cites W2128936065 @default.
- W2033687798 cites W2135840307 @default.
- W2033687798 cites W2137646827 @default.