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• W2033701095 abstract "Abstract A rapid and selective liquid chromatographic method is described for the simultaneous determination of 10,11-methylenedioxy- N-n -propylnoraporphine (MDO-APO) and N-n -propylnorapomorphine (NPA) in Cunninghamella elegans (ATCC 9245) cultures. Isolation of substrate R -(−)- or S -(+)-MDO-NPA, metabolite R -(−)- or S -(+)-NPA and internal standard R -(−)-10,11-methylenedioxyaporphine (MDO-APO) was achieved via liquid-liquid extraction from buffered fermentation samples (pH 7.5), and were confirmed by the addition of chemically pure compounds. Aliquots were separated on a 3-μm Supelcosil LC-CN column using acetonitrile-phosphate (pH 3.0) (19+81) as eluent and quantified by monitoring the ultraviolet absorbance at 280 nm. A single chromatographic run could be completed in ca. 13 min; no interference from other metabolites or endogenous compounds was noted. The detection limit for aporphines was 0.33 nmol ml −1 ; the within-assay and day-to-day variation were consistently lower than ca. 7%. The time course of MDO-NPA metabolism by the fungus was also studied. The bioconversion studies showed that (+)-MDO-NPA was O -dealkylated to a slightly higher extent to (+)-NPA by C. elegans compared with the (−)-enantiomer; after 4 days of incubation the (+)-NPA/(−)-NPA product ratio was calculated to be 3.2:1." @default.
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• W2033701095 date "1990-01-01" @default.
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• W2033701095 title "Determination of O-dealkylation products of R-(−)- and S-(+)-10,11-methylenedioxy-N-n-propylnoraporphine in Cunninghamella elegans cultures by liquid chromatography" @default.
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• W2033701095 doi "https://doi.org/10.1016/s0003-2670(00)83478-9" @default.
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