Matches in SemOpenAlex for { <https://semopenalex.org/work/W2033702989> ?p ?o ?g. }
- W2033702989 endingPage "1483" @default.
- W2033702989 startingPage "1471" @default.
- W2033702989 abstract "Vibrio coralliilyticus has been implicated as an important pathogen of coral species worldwide. In this study, the nearly complete genome of Vibrio coralliilyticus strain P1 (LMG23696) was sequenced and proteases implicated in virulence of the strain were specifically investigated. The genome sequence of P1 (5 513 256 bp in size) consisted of 5222 coding sequences and 58 RNA genes (53 tRNAs and at least 5 rRNAs). Seventeen metalloprotease and effector (vgrG, hlyA and hcp) genes were identified in the genome and expressed proteases were also detected in the secretome of P1. As the VcpA zinc-metalloprotease has been considered an important virulence factor of V. coralliilyticus, a vcpA deletion mutant was constructed to evaluate the effect of this gene in animal pathogenesis. Both wild-type and mutant (ΔvcpA) strains exhibited similar virulence characteristics that resulted in high mortality in Artemia and Drosophila pathogenicity bioassays and strong photosystem II inactivation of the coral dinoflagellate endosymbiont (Symbiodinium). In contrast, the ΔvcpA mutant demonstrated higher hemolytic activity and secreted 18 proteins not secreted by the wild type. These proteins included four types of metalloproteases, a chitinase, a hemolysin-related protein RbmC, the Hcp protein and 12 hypothetical proteins. Overall, the results of this study indicate that V. coralliilyticus strain P1 has a diverse virulence repertoire that possibly enables this bacterium to be an efficient animal pathogen." @default.
- W2033702989 created "2016-06-24" @default.
- W2033702989 creator A5000690971 @default.
- W2033702989 creator A5008286076 @default.
- W2033702989 creator A5010720388 @default.
- W2033702989 creator A5021816680 @default.
- W2033702989 creator A5022791933 @default.
- W2033702989 creator A5033456016 @default.
- W2033702989 creator A5038144119 @default.
- W2033702989 creator A5045067140 @default.
- W2033702989 creator A5046236889 @default.
- W2033702989 creator A5057270645 @default.
- W2033702989 creator A5065558873 @default.
- W2033702989 date "2011-03-31" @default.
- W2033702989 modified "2023-10-06" @default.
- W2033702989 title "Genomic and proteomic analyses of the coral pathogen Vibrio coralliilyticus reveal a diverse virulence repertoire" @default.
- W2033702989 cites W1501451070 @default.
- W2033702989 cites W1632437692 @default.
- W2033702989 cites W1773965900 @default.
- W2033702989 cites W1811655228 @default.
- W2033702989 cites W1938603644 @default.
- W2033702989 cites W1968206284 @default.
- W2033702989 cites W1970353442 @default.
- W2033702989 cites W1971254634 @default.
- W2033702989 cites W1971268821 @default.
- W2033702989 cites W1971870251 @default.
- W2033702989 cites W1973538824 @default.
- W2033702989 cites W1975506356 @default.
- W2033702989 cites W1980996405 @default.
- W2033702989 cites W1986658525 @default.
- W2033702989 cites W1998652482 @default.
- W2033702989 cites W2005714590 @default.
- W2033702989 cites W2009916885 @default.
- W2033702989 cites W2010779190 @default.
- W2033702989 cites W2025185109 @default.
- W2033702989 cites W2025212357 @default.
- W2033702989 cites W2028102134 @default.
- W2033702989 cites W2043458157 @default.
- W2033702989 cites W2045846497 @default.
- W2033702989 cites W2046103870 @default.
- W2033702989 cites W2050693575 @default.
- W2033702989 cites W2056642745 @default.
- W2033702989 cites W2057508404 @default.
- W2033702989 cites W2077709250 @default.
- W2033702989 cites W2079831464 @default.
- W2033702989 cites W2096513605 @default.
- W2033702989 cites W2104710401 @default.
- W2033702989 cites W2106616156 @default.
- W2033702989 cites W2111665228 @default.
- W2033702989 cites W2114094146 @default.
- W2033702989 cites W2118040479 @default.
- W2033702989 cites W2125734010 @default.
- W2033702989 cites W2126354727 @default.
- W2033702989 cites W2128114769 @default.
- W2033702989 cites W2133166824 @default.
- W2033702989 cites W2133392388 @default.
- W2033702989 cites W2133566955 @default.
- W2033702989 cites W2137616828 @default.
- W2033702989 cites W2142598180 @default.
- W2033702989 cites W2145547410 @default.
- W2033702989 cites W2150623405 @default.
- W2033702989 cites W2151936805 @default.
- W2033702989 cites W2151970090 @default.
- W2033702989 cites W2167803442 @default.
- W2033702989 doi "https://doi.org/10.1038/ismej.2011.19" @default.
- W2033702989 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/3160677" @default.
- W2033702989 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/21451583" @default.
- W2033702989 hasPublicationYear "2011" @default.
- W2033702989 type Work @default.
- W2033702989 sameAs 2033702989 @default.
- W2033702989 citedByCount "86" @default.
- W2033702989 countsByYear W20337029892012 @default.
- W2033702989 countsByYear W20337029892013 @default.
- W2033702989 countsByYear W20337029892014 @default.
- W2033702989 countsByYear W20337029892015 @default.
- W2033702989 countsByYear W20337029892016 @default.
- W2033702989 countsByYear W20337029892017 @default.
- W2033702989 countsByYear W20337029892018 @default.
- W2033702989 countsByYear W20337029892019 @default.
- W2033702989 countsByYear W20337029892020 @default.
- W2033702989 countsByYear W20337029892021 @default.
- W2033702989 countsByYear W20337029892022 @default.
- W2033702989 countsByYear W20337029892023 @default.
- W2033702989 crossrefType "journal-article" @default.
- W2033702989 hasAuthorship W2033702989A5000690971 @default.
- W2033702989 hasAuthorship W2033702989A5008286076 @default.
- W2033702989 hasAuthorship W2033702989A5010720388 @default.
- W2033702989 hasAuthorship W2033702989A5021816680 @default.
- W2033702989 hasAuthorship W2033702989A5022791933 @default.
- W2033702989 hasAuthorship W2033702989A5033456016 @default.
- W2033702989 hasAuthorship W2033702989A5038144119 @default.
- W2033702989 hasAuthorship W2033702989A5045067140 @default.
- W2033702989 hasAuthorship W2033702989A5046236889 @default.
- W2033702989 hasAuthorship W2033702989A5057270645 @default.
- W2033702989 hasAuthorship W2033702989A5065558873 @default.
- W2033702989 hasBestOaLocation W20337029891 @default.
- W2033702989 hasConcept C104317684 @default.
- W2033702989 hasConcept C141231307 @default.